The many lives of IL-9: a question of survival?
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The many lives of IL-9: a question of survival? / Wilhelm, Christoph; Turner, Jan Eric; Jacques, Van Snick; Stockinger, Brigitta.
In: NAT IMMUNOL, Vol. 13, No. 7, 7, 01.07.2012, p. 637-641.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The many lives of IL-9: a question of survival?
AU - Wilhelm, Christoph
AU - Turner, Jan Eric
AU - Jacques, Van Snick
AU - Stockinger, Brigitta
PY - 2012/7/1
Y1 - 2012/7/1
N2 - Although the cytokine interleukin 9 (IL-9) was discovered decades ago, it remains one of the most enigmatic cytokines identified so far, in particular because its functional activities remain far from clear. Breakthroughs made through the use of IL-9 reporter mice have allowed the identification of cell types that produce IL-9 in vivo and, contrary to expectations based on previous results obtained in vitro, it is not T cells but instead a previously unknown type of innate lymphoid cell, called the 'ILC2 cell', that is the main cell type that expresses IL-9 in vivo. In this perspective, we put forward a hypothesis about the potential biological functions of IL-9 in the immune system and beyond.
AB - Although the cytokine interleukin 9 (IL-9) was discovered decades ago, it remains one of the most enigmatic cytokines identified so far, in particular because its functional activities remain far from clear. Breakthroughs made through the use of IL-9 reporter mice have allowed the identification of cell types that produce IL-9 in vivo and, contrary to expectations based on previous results obtained in vitro, it is not T cells but instead a previously unknown type of innate lymphoid cell, called the 'ILC2 cell', that is the main cell type that expresses IL-9 in vivo. In this perspective, we put forward a hypothesis about the potential biological functions of IL-9 in the immune system and beyond.
KW - Animals
KW - Humans
KW - Mice
KW - Cell Survival/immunology
KW - Interleukin-9/immunology
KW - Th2 Cells/immunology
KW - Animals
KW - Humans
KW - Mice
KW - Cell Survival/immunology
KW - Interleukin-9/immunology
KW - Th2 Cells/immunology
U2 - 10.1038/ni.2303
DO - 10.1038/ni.2303
M3 - SCORING: Journal article
C2 - 22713829
VL - 13
SP - 637
EP - 641
JO - NAT IMMUNOL
JF - NAT IMMUNOL
SN - 1529-2908
IS - 7
M1 - 7
ER -