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The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

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The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. / Study, International HIV Controllers; Pereyra, Florencia; Jia, Xiaoming; McLaren, Paul J; Telenti, Amalio; Bakker, de; Paul, I W; Walker, Bruce D; Ripke, Stephan; Brumme, Chanson J; Pulit, Sara L; Carrington, Mary; Kadie, Carl M; Carlson, Jonathan M; Heckerman, David; Graham, Robert R; Plenge, Robert M; Deeks, Steven G; Gianniny, Lauren; Crawford, Gabriel; Sullivan, Jordan; Gonzalez, Elena; Davies, Leela; Camargo, Amy; Moore, Jamie M; Beattie, Nicole; Gupta, Supriya; Crenshaw, Andrew; Burtt, Noël P; Guiducci, Candace; Gupta, Namrata; Gao, Xiaojiang; Qi, Ying; Yuki, Yuko; Piechocka-Trocha, Alicja; Cutrell, Emily; Rosenberg, Rachel; Moss, Kristin L; Lemay, Paul; O'Leary, Jessica; Schaefer, Todd; Verma, Pranshu; Toth, Ildiko; Block, Brian; Baker, Brett; Rothchild, Alissa; Lian, Jeffrey; Proudfoot, Jacqueline; Alvino, Donna Marie L; Addo, Marylyn; Addo, Marylyn M; Allen, Todd M; Altfeld, Marcus; Henn, Matthew R; Sylvie, Le Gall; Streeck, Hendrik; Haas, David W; Kuritzkes, Daniel R; Robbins, Gregory K; Shafer, Robert W; Gulick, Roy M; Shikuma, Cecilia M; Haubrich, Richard; Riddler, Sharon; Sax, Paul E; Daar, Eric S; Ribaudo, Heather J; Agan, Brian; Agarwal, Shanu; Ahern, Richard L; Allen, Brady L; Altidor, Sherly; Altschuler, Eric L; Ambardar, Sujata; Anastos, Kathryn; Anderson, Ben; Anderson, Val; Andrady, Ushan; Antoniskis, Diana; Bangsberg, David; Barbaro, Daniel; Barrie, William; Bartczak, J; Barton, Simon; Basden, Patricia; Basgoz, Nesli; Bazner, Suzane; Bellos, Nicholaos C; Benson, Anne M; Berger, Judith; Bernard, Nicole F; Bernard, Annette M; Birch, Christopher; Bodner, Stanley J; Bolan, Robert K; Boudreaux, Emilie T; Bradley, Meg; Braun, James F; Brndjar, Jon E; Brown, Stephen J; Brown, Katherine; Brown, Sheldon T; Burack, Jedidiah; Bush, Larry M; Cafaro, Virginia; Campbell, Omobolaji; Campbell, John; Carlson, Robert H; Carmichael, J Kevin; Casey, Kathleen K; Cavacuiti, Chris; Celestin, Gregory; Chambers, Steven T; Chez, Nancy; Chirch, Lisa M; Cimoch, Paul J; Cohen, Daniel; Cohn, Lillian E; Conway, Brian; Cooper, David A; Cornelson, Brian; Cox, David T; Cristofano, Michael V; Cuchural, George; Czartoski, Julie L; Dahman, Joseph M; Daly, Jennifer S; Davis, Benjamin T; Davis, Kristine; Davod, Sheila M; DeJesus, Edwin; Dietz, Craig A; Dunham, Eleanor; Dunn, Michael E; Ellerin, Todd B; Eron, Joseph J; Fangman, John J W; Farel, Claire E; Ferlazzo, Helen; Fidler, Sarah; Fleenor-Ford, Anita; Frankel, Renee; Freedberg, Kenneth A; French, Neel K; Fuchs, Jonathan D; Fuller, Jon D; Gaberman, Jonna; Gallant, Joel E; Gandhi, Rajesh T; Garcia, Efrain; Garmon, Donald; Gathe, Joseph C; Gaultier, Cyril R; Gebre, Wondwoosen; Gilman, Frank D; Gilson, Ian; Goepfert, Paul A; Gottlieb, Michael S; Goulston, Claudia; Groger, Richard K; Gurley, T Douglas; Haber, Stuart; Hardwicke, Robin; Hardy, W David; Harrigan, P Richard; Hawkins, Trevor N; Heath, Sonya; Hecht, Frederick M; Henry, W Keith; Hladek, Melissa; Hoffman, Robert P; Horton, James M; Hsu, Ricky K; Huhn, Gregory D; Hunt, Peter; Hupert, Mark J; Illeman, Mark L; Jaeger, Hans; Jellinger, Robert M; John, Mina; Johnson, Jennifer A; Johnson, Kristin L; Johnson, Heather; Johnson, Kay; Joly, Jennifer; Jordan, Wilbert C; Kauffman, Carol A; Khanlou, Homayoon; Killian, Robert K; Kim, Arthur Y; Kim, David D; Kinder, Clifford A; Kirchner, Jeffrey T; Kogelman, Laura; Kojic, Erna Milunka; Korthuis, P Todd; Kurisu, Wayne; Kwon, Douglas S; LaMar, Melissa; Lampiris, Harry; Lanzafame, Massimiliano; Lederman, Michael M; Lee, David M; Lee, Jean M L; Lee, Marah J; Lee, Edward T Y; Lemoine, Janice; Levy, Jay A; Llibre, Josep M; Liguori, Michael A; Little, Susan J; Liu, Anne Y; Lopez, Alvaro J; Loutfy, Mono R; Loy, Dawn; Mohammed, Debbie Y; Man, Alan; Mansour, Michael K; Marconi, Vincent C; Markowitz, Martin; Marques, Rui; Martin, Jeffrey N; Martin, Harold L; Mayer, Kenneth Hugh; McElrath, M Juliana; McGhee, Theresa A; McGovern, Barbara H; McGowan, Katherine; McIntyre, Dawn; Mcleod, Gavin X; Menezes, Prema; Mesa, Greg; Metroka, Craig E; Meyer-Olson, Dirk; Miller, Andy O; Montgomery, Kate; Mounzer, Karam C; Nagami, Ellen H; Nagin, Iris; Nahass, Ronald G; Nelson, Margret O; Nielsen, Craig; Norene, David L; O'Connor, David H; Ojikutu, Bisola O; Okulicz, Jason; Oladehin, Olakunle O; Oldfield, Edward C; Olender, Susan A; Ostrowski, Mario; Owen, William F; Pae, Eunice; Parsonnet, Jeffrey; Pavlatos, Andrew M; Perlmutter, Aaron M; Pierce, Michael N; Pincus, Jonathan M; Pisani, Leandro; Price, Lawrence Jay; Proia, Laurie; Prokesch, [Unbekannt].

In: SCIENCE, Vol. 330, No. 6010, 6010, 2010, p. 1551-1557.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Study, IHIVC, Pereyra, F, Jia, X, McLaren, PJ, Telenti, A, Bakker, D, Paul, IW, Walker, BD, Ripke, S, Brumme, CJ, Pulit, SL, Carrington, M, Kadie, CM, Carlson, JM, Heckerman, D, Graham, RR, Plenge, RM, Deeks, SG, Gianniny, L, Crawford, G, Sullivan, J, Gonzalez, E, Davies, L, Camargo, A, Moore, JM, Beattie, N, Gupta, S, Crenshaw, A, Burtt, NP, Guiducci, C, Gupta, N, Gao, X, Qi, Y, Yuki, Y, Piechocka-Trocha, A, Cutrell, E, Rosenberg, R, Moss, KL, Lemay, P, O'Leary, J, Schaefer, T, Verma, P, Toth, I, Block, B, Baker, B, Rothchild, A, Lian, J, Proudfoot, J, Alvino, DML, Addo, M, Addo, MM, Allen, TM, Altfeld, M, Henn, MR, Sylvie, LG, Streeck, H, Haas, DW, Kuritzkes, DR, Robbins, GK, Shafer, RW, Gulick, RM, Shikuma, CM, Haubrich, R, Riddler, S, Sax, PE, Daar, ES, Ribaudo, HJ, Agan, B, Agarwal, S, Ahern, RL, Allen, BL, Altidor, S, Altschuler, EL, Ambardar, S, Anastos, K, Anderson, B, Anderson, V, Andrady, U, Antoniskis, D, Bangsberg, D, Barbaro, D, Barrie, W, Bartczak, J, Barton, S, Basden, P, Basgoz, N, Bazner, S, Bellos, NC, Benson, AM, Berger, J, Bernard, NF, Bernard, AM, Birch, C, Bodner, SJ, Bolan, RK, Boudreaux, ET, Bradley, M, Braun, JF, Brndjar, JE, Brown, SJ, Brown, K, Brown, ST, Burack, J, Bush, LM, Cafaro, V, Campbell, O, Campbell, J, Carlson, RH, Carmichael, JK, Casey, KK, Cavacuiti, C, Celestin, G, Chambers, ST, Chez, N, Chirch, LM, Cimoch, PJ, Cohen, D, Cohn, LE, Conway, B, Cooper, DA, Cornelson, B, Cox, DT, Cristofano, MV, Cuchural, G, Czartoski, JL, Dahman, JM, Daly, JS, Davis, BT, Davis, K, Davod, SM, DeJesus, E, Dietz, CA, Dunham, E, Dunn, ME, Ellerin, TB, Eron, JJ, Fangman, JJW, Farel, CE, Ferlazzo, H, Fidler, S, Fleenor-Ford, A, Frankel, R, Freedberg, KA, French, NK, Fuchs, JD, Fuller, JD, Gaberman, J, Gallant, JE, Gandhi, RT, Garcia, E, Garmon, D, Gathe, JC, Gaultier, CR, Gebre, W, Gilman, FD, Gilson, I, Goepfert, PA, Gottlieb, MS, Goulston, C, Groger, RK, Gurley, TD, Haber, S, Hardwicke, R, Hardy, WD, Harrigan, PR, Hawkins, TN, Heath, S, Hecht, FM, Henry, WK, Hladek, M, Hoffman, RP, Horton, JM, Hsu, RK, Huhn, GD, Hunt, P, Hupert, MJ, Illeman, ML, Jaeger, H, Jellinger, RM, John, M, Johnson, JA, Johnson, KL, Johnson, H, Johnson, K, Joly, J, Jordan, WC, Kauffman, CA, Khanlou, H, Killian, RK, Kim, AY, Kim, DD, Kinder, CA, Kirchner, JT, Kogelman, L, Kojic, EM, Korthuis, PT, Kurisu, W, Kwon, DS, LaMar, M, Lampiris, H, Lanzafame, M, Lederman, MM, Lee, DM, Lee, JML, Lee, MJ, Lee, ETY, Lemoine, J, Levy, JA, Llibre, JM, Liguori, MA, Little, SJ, Liu, AY, Lopez, AJ, Loutfy, MR, Loy, D, Mohammed, DY, Man, A, Mansour, MK, Marconi, VC, Markowitz, M, Marques, R, Martin, JN, Martin, HL, Mayer, KH, McElrath, MJ, McGhee, TA, McGovern, BH, McGowan, K, McIntyre, D, Mcleod, GX, Menezes, P, Mesa, G, Metroka, CE, Meyer-Olson, D, Miller, AO, Montgomery, K, Mounzer, KC, Nagami, EH, Nagin, I, Nahass, RG, Nelson, MO, Nielsen, C, Norene, DL, O'Connor, DH, Ojikutu, BO, Okulicz, J, Oladehin, OO, Oldfield, EC, Olender, SA, Ostrowski, M, Owen, WF, Pae, E, Parsonnet, J, Pavlatos, AM, Perlmutter, AM, Pierce, MN, Pincus, JM, Pisani, L, Price, LJ, Proia, L & Prokesch, U 2010, 'The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.', SCIENCE, vol. 330, no. 6010, 6010, pp. 1551-1557. <http://www.ncbi.nlm.nih.gov/pubmed/21051598?dopt=Citation>

APA

Study, I. HIV. C., Pereyra, F., Jia, X., McLaren, P. J., Telenti, A., Bakker, D., Paul, I. W., Walker, B. D., Ripke, S., Brumme, C. J., Pulit, S. L., Carrington, M., Kadie, C. M., Carlson, J. M., Heckerman, D., Graham, R. R., Plenge, R. M., Deeks, S. G., Gianniny, L., ... Prokesch, U. (2010). The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. SCIENCE, 330(6010), 1551-1557. [6010]. http://www.ncbi.nlm.nih.gov/pubmed/21051598?dopt=Citation

Vancouver

Study IHIVC, Pereyra F, Jia X, McLaren PJ, Telenti A, Bakker D et al. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. SCIENCE. 2010;330(6010):1551-1557. 6010.

Bibtex

@article{8d70a738a89a4a149d0480a3bb548569,
title = "The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.",
abstract = "Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection.",
keywords = "Humans, Cohort Studies, Disease Progression, Logistic Models, Viral Load, Models, Molecular, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Alleles, Protein Conformation, Haplotypes, Immunity, Innate, European Continental Ancestry Group/genetics, CD8-Positive T-Lymphocytes/immunology, African Americans/genetics, Amino Acids/physiology, *Antigen Presentation, *Genes, MHC Class I, HIV Antigens/immunology, HIV Infections/ethnology/*genetics/*immunology/virology, HIV Long-Term Survivors, *HIV-1/immunology, HLA-A Antigens/chemistry/genetics/immunology/metabolism, HLA-B Antigens/chemistry/*genetics/immunology/metabolism, HLA-C Antigens/chemistry/genetics/immunology/metabolism, Hispanic Americans/genetics, Humans, Cohort Studies, Disease Progression, Logistic Models, Viral Load, Models, Molecular, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Alleles, Protein Conformation, Haplotypes, Immunity, Innate, European Continental Ancestry Group/genetics, CD8-Positive T-Lymphocytes/immunology, African Americans/genetics, Amino Acids/physiology, *Antigen Presentation, *Genes, MHC Class I, HIV Antigens/immunology, HIV Infections/ethnology/*genetics/*immunology/virology, HIV Long-Term Survivors, *HIV-1/immunology, HLA-A Antigens/chemistry/genetics/immunology/metabolism, HLA-B Antigens/chemistry/*genetics/immunology/metabolism, HLA-C Antigens/chemistry/genetics/immunology/metabolism, Hispanic Americans/genetics",
author = "Study, {International HIV Controllers} and Florencia Pereyra and Xiaoming Jia and McLaren, {Paul J} and Amalio Telenti and de Bakker and Paul, {I W} and Walker, {Bruce D} and Stephan Ripke and Brumme, {Chanson J} and Pulit, {Sara L} and Mary Carrington and Kadie, {Carl M} and Carlson, {Jonathan M} and David Heckerman and Graham, {Robert R} and Plenge, {Robert M} and Deeks, {Steven G} and Lauren Gianniny and Gabriel Crawford and Jordan Sullivan and Elena Gonzalez and Leela Davies and Amy Camargo and Moore, {Jamie M} and Nicole Beattie and Supriya Gupta and Andrew Crenshaw and Burtt, {No{\"e}l P} and Candace Guiducci and Namrata Gupta and Xiaojiang Gao and Ying Qi and Yuko Yuki and Alicja Piechocka-Trocha and Emily Cutrell and Rachel Rosenberg and Moss, {Kristin L} and Paul Lemay and Jessica O'Leary and Todd Schaefer and Pranshu Verma and Ildiko Toth and Brian Block and Brett Baker and Alissa Rothchild and Jeffrey Lian and Jacqueline Proudfoot and Alvino, {Donna Marie L} and Marylyn Addo and Addo, {Marylyn M} and Allen, {Todd M} and Marcus Altfeld and Henn, {Matthew R} and Sylvie, {Le Gall} and Hendrik Streeck and Haas, {David W} and Kuritzkes, {Daniel R} and Robbins, {Gregory K} and Shafer, {Robert W} and Gulick, {Roy M} and Shikuma, {Cecilia M} and Richard Haubrich and Sharon Riddler and Sax, {Paul E} and Daar, {Eric S} and Ribaudo, {Heather J} and Brian Agan and Shanu Agarwal and Ahern, {Richard L} and Allen, {Brady L} and Sherly Altidor and Altschuler, {Eric L} and Sujata Ambardar and Kathryn Anastos and Ben Anderson and Val Anderson and Ushan Andrady and Diana Antoniskis and David Bangsberg and Daniel Barbaro and William Barrie and J Bartczak and Simon Barton and Patricia Basden and Nesli Basgoz and Suzane Bazner and Bellos, {Nicholaos C} and Benson, {Anne M} and Judith Berger and Bernard, {Nicole F} and Bernard, {Annette M} and Christopher Birch and Bodner, {Stanley J} and Bolan, {Robert K} and Boudreaux, {Emilie T} and Meg Bradley and Braun, {James F} and Brndjar, {Jon E} and Brown, {Stephen J} and Katherine Brown and Brown, {Sheldon T} and Jedidiah Burack and Bush, {Larry M} and Virginia Cafaro and Omobolaji Campbell and John Campbell and Carlson, {Robert H} and Carmichael, {J Kevin} and Casey, {Kathleen K} and Chris Cavacuiti and Gregory Celestin and Chambers, {Steven T} and Nancy Chez and Chirch, {Lisa M} and Cimoch, {Paul J} and Daniel Cohen and Cohn, {Lillian E} and Brian Conway and Cooper, {David A} and Brian Cornelson and Cox, {David T} and Cristofano, {Michael V} and George Cuchural and Czartoski, {Julie L} and Dahman, {Joseph M} and Daly, {Jennifer S} and Davis, {Benjamin T} and Kristine Davis and Davod, {Sheila M} and Edwin DeJesus and Dietz, {Craig A} and Eleanor Dunham and Dunn, {Michael E} and Ellerin, {Todd B} and Eron, {Joseph J} and Fangman, {John J W} and Farel, {Claire E} and Helen Ferlazzo and Sarah Fidler and Anita Fleenor-Ford and Renee Frankel and Freedberg, {Kenneth A} and French, {Neel K} and Fuchs, {Jonathan D} and Fuller, {Jon D} and Jonna Gaberman and Gallant, {Joel E} and Gandhi, {Rajesh T} and Efrain Garcia and Donald Garmon and Gathe, {Joseph C} and Gaultier, {Cyril R} and Wondwoosen Gebre and Gilman, {Frank D} and Ian Gilson and Goepfert, {Paul A} and Gottlieb, {Michael S} and Claudia Goulston and Groger, {Richard K} and Gurley, {T Douglas} and Stuart Haber and Robin Hardwicke and Hardy, {W David} and Harrigan, {P Richard} and Hawkins, {Trevor N} and Sonya Heath and Hecht, {Frederick M} and Henry, {W Keith} and Melissa Hladek and Hoffman, {Robert P} and Horton, {James M} and Hsu, {Ricky K} and Huhn, {Gregory D} and Peter Hunt and Hupert, {Mark J} and Illeman, {Mark L} and Hans Jaeger and Jellinger, {Robert M} and Mina John and Johnson, {Jennifer A} and Johnson, {Kristin L} and Heather Johnson and Kay Johnson and Jennifer Joly and Jordan, {Wilbert C} and Kauffman, {Carol A} and Homayoon Khanlou and Killian, {Robert K} and Kim, {Arthur Y} and Kim, {David D} and Kinder, {Clifford A} and Kirchner, {Jeffrey T} and Laura Kogelman and Kojic, {Erna Milunka} and Korthuis, {P Todd} and Wayne Kurisu and Kwon, {Douglas S} and Melissa LaMar and Harry Lampiris and Massimiliano Lanzafame and Lederman, {Michael M} and Lee, {David M} and Lee, {Jean M L} and Lee, {Marah J} and Lee, {Edward T Y} and Janice Lemoine and Levy, {Jay A} and Llibre, {Josep M} and Liguori, {Michael A} and Little, {Susan J} and Liu, {Anne Y} and Lopez, {Alvaro J} and Loutfy, {Mono R} and Dawn Loy and Mohammed, {Debbie Y} and Alan Man and Mansour, {Michael K} and Marconi, {Vincent C} and Martin Markowitz and Rui Marques and Martin, {Jeffrey N} and Martin, {Harold L} and Mayer, {Kenneth Hugh} and McElrath, {M Juliana} and McGhee, {Theresa A} and McGovern, {Barbara H} and Katherine McGowan and Dawn McIntyre and Mcleod, {Gavin X} and Prema Menezes and Greg Mesa and Metroka, {Craig E} and Dirk Meyer-Olson and Miller, {Andy O} and Kate Montgomery and Mounzer, {Karam C} and Nagami, {Ellen H} and Iris Nagin and Nahass, {Ronald G} and Nelson, {Margret O} and Craig Nielsen and Norene, {David L} and O'Connor, {David H} and Ojikutu, {Bisola O} and Jason Okulicz and Oladehin, {Olakunle O} and Oldfield, {Edward C} and Olender, {Susan A} and Mario Ostrowski and Owen, {William F} and Eunice Pae and Jeffrey Parsonnet and Pavlatos, {Andrew M} and Perlmutter, {Aaron M} and Pierce, {Michael N} and Pincus, {Jonathan M} and Leandro Pisani and Price, {Lawrence Jay} and Laurie Proia and [Unbekannt] Prokesch",
year = "2010",
language = "English",
volume = "330",
pages = "1551--1557",
journal = "SCIENCE",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6010",

}

RIS

TY - JOUR

T1 - The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

AU - Study, International HIV Controllers

AU - Pereyra, Florencia

AU - Jia, Xiaoming

AU - McLaren, Paul J

AU - Telenti, Amalio

AU - Bakker, de

AU - Paul, I W

AU - Walker, Bruce D

AU - Ripke, Stephan

AU - Brumme, Chanson J

AU - Pulit, Sara L

AU - Carrington, Mary

AU - Kadie, Carl M

AU - Carlson, Jonathan M

AU - Heckerman, David

AU - Graham, Robert R

AU - Plenge, Robert M

AU - Deeks, Steven G

AU - Gianniny, Lauren

AU - Crawford, Gabriel

AU - Sullivan, Jordan

AU - Gonzalez, Elena

AU - Davies, Leela

AU - Camargo, Amy

AU - Moore, Jamie M

AU - Beattie, Nicole

AU - Gupta, Supriya

AU - Crenshaw, Andrew

AU - Burtt, Noël P

AU - Guiducci, Candace

AU - Gupta, Namrata

AU - Gao, Xiaojiang

AU - Qi, Ying

AU - Yuki, Yuko

AU - Piechocka-Trocha, Alicja

AU - Cutrell, Emily

AU - Rosenberg, Rachel

AU - Moss, Kristin L

AU - Lemay, Paul

AU - O'Leary, Jessica

AU - Schaefer, Todd

AU - Verma, Pranshu

AU - Toth, Ildiko

AU - Block, Brian

AU - Baker, Brett

AU - Rothchild, Alissa

AU - Lian, Jeffrey

AU - Proudfoot, Jacqueline

AU - Alvino, Donna Marie L

AU - Addo, Marylyn

AU - Addo, Marylyn M

AU - Allen, Todd M

AU - Altfeld, Marcus

AU - Henn, Matthew R

AU - Sylvie, Le Gall

AU - Streeck, Hendrik

AU - Haas, David W

AU - Kuritzkes, Daniel R

AU - Robbins, Gregory K

AU - Shafer, Robert W

AU - Gulick, Roy M

AU - Shikuma, Cecilia M

AU - Haubrich, Richard

AU - Riddler, Sharon

AU - Sax, Paul E

AU - Daar, Eric S

AU - Ribaudo, Heather J

AU - Agan, Brian

AU - Agarwal, Shanu

AU - Ahern, Richard L

AU - Allen, Brady L

AU - Altidor, Sherly

AU - Altschuler, Eric L

AU - Ambardar, Sujata

AU - Anastos, Kathryn

AU - Anderson, Ben

AU - Anderson, Val

AU - Andrady, Ushan

AU - Antoniskis, Diana

AU - Bangsberg, David

AU - Barbaro, Daniel

AU - Barrie, William

AU - Bartczak, J

AU - Barton, Simon

AU - Basden, Patricia

AU - Basgoz, Nesli

AU - Bazner, Suzane

AU - Bellos, Nicholaos C

AU - Benson, Anne M

AU - Berger, Judith

AU - Bernard, Nicole F

AU - Bernard, Annette M

AU - Birch, Christopher

AU - Bodner, Stanley J

AU - Bolan, Robert K

AU - Boudreaux, Emilie T

AU - Bradley, Meg

AU - Braun, James F

AU - Brndjar, Jon E

AU - Brown, Stephen J

AU - Brown, Katherine

AU - Brown, Sheldon T

AU - Burack, Jedidiah

AU - Bush, Larry M

AU - Cafaro, Virginia

AU - Campbell, Omobolaji

AU - Campbell, John

AU - Carlson, Robert H

AU - Carmichael, J Kevin

AU - Casey, Kathleen K

AU - Cavacuiti, Chris

AU - Celestin, Gregory

AU - Chambers, Steven T

AU - Chez, Nancy

AU - Chirch, Lisa M

AU - Cimoch, Paul J

AU - Cohen, Daniel

AU - Cohn, Lillian E

AU - Conway, Brian

AU - Cooper, David A

AU - Cornelson, Brian

AU - Cox, David T

AU - Cristofano, Michael V

AU - Cuchural, George

AU - Czartoski, Julie L

AU - Dahman, Joseph M

AU - Daly, Jennifer S

AU - Davis, Benjamin T

AU - Davis, Kristine

AU - Davod, Sheila M

AU - DeJesus, Edwin

AU - Dietz, Craig A

AU - Dunham, Eleanor

AU - Dunn, Michael E

AU - Ellerin, Todd B

AU - Eron, Joseph J

AU - Fangman, John J W

AU - Farel, Claire E

AU - Ferlazzo, Helen

AU - Fidler, Sarah

AU - Fleenor-Ford, Anita

AU - Frankel, Renee

AU - Freedberg, Kenneth A

AU - French, Neel K

AU - Fuchs, Jonathan D

AU - Fuller, Jon D

AU - Gaberman, Jonna

AU - Gallant, Joel E

AU - Gandhi, Rajesh T

AU - Garcia, Efrain

AU - Garmon, Donald

AU - Gathe, Joseph C

AU - Gaultier, Cyril R

AU - Gebre, Wondwoosen

AU - Gilman, Frank D

AU - Gilson, Ian

AU - Goepfert, Paul A

AU - Gottlieb, Michael S

AU - Goulston, Claudia

AU - Groger, Richard K

AU - Gurley, T Douglas

AU - Haber, Stuart

AU - Hardwicke, Robin

AU - Hardy, W David

AU - Harrigan, P Richard

AU - Hawkins, Trevor N

AU - Heath, Sonya

AU - Hecht, Frederick M

AU - Henry, W Keith

AU - Hladek, Melissa

AU - Hoffman, Robert P

AU - Horton, James M

AU - Hsu, Ricky K

AU - Huhn, Gregory D

AU - Hunt, Peter

AU - Hupert, Mark J

AU - Illeman, Mark L

AU - Jaeger, Hans

AU - Jellinger, Robert M

AU - John, Mina

AU - Johnson, Jennifer A

AU - Johnson, Kristin L

AU - Johnson, Heather

AU - Johnson, Kay

AU - Joly, Jennifer

AU - Jordan, Wilbert C

AU - Kauffman, Carol A

AU - Khanlou, Homayoon

AU - Killian, Robert K

AU - Kim, Arthur Y

AU - Kim, David D

AU - Kinder, Clifford A

AU - Kirchner, Jeffrey T

AU - Kogelman, Laura

AU - Kojic, Erna Milunka

AU - Korthuis, P Todd

AU - Kurisu, Wayne

AU - Kwon, Douglas S

AU - LaMar, Melissa

AU - Lampiris, Harry

AU - Lanzafame, Massimiliano

AU - Lederman, Michael M

AU - Lee, David M

AU - Lee, Jean M L

AU - Lee, Marah J

AU - Lee, Edward T Y

AU - Lemoine, Janice

AU - Levy, Jay A

AU - Llibre, Josep M

AU - Liguori, Michael A

AU - Little, Susan J

AU - Liu, Anne Y

AU - Lopez, Alvaro J

AU - Loutfy, Mono R

AU - Loy, Dawn

AU - Mohammed, Debbie Y

AU - Man, Alan

AU - Mansour, Michael K

AU - Marconi, Vincent C

AU - Markowitz, Martin

AU - Marques, Rui

AU - Martin, Jeffrey N

AU - Martin, Harold L

AU - Mayer, Kenneth Hugh

AU - McElrath, M Juliana

AU - McGhee, Theresa A

AU - McGovern, Barbara H

AU - McGowan, Katherine

AU - McIntyre, Dawn

AU - Mcleod, Gavin X

AU - Menezes, Prema

AU - Mesa, Greg

AU - Metroka, Craig E

AU - Meyer-Olson, Dirk

AU - Miller, Andy O

AU - Montgomery, Kate

AU - Mounzer, Karam C

AU - Nagami, Ellen H

AU - Nagin, Iris

AU - Nahass, Ronald G

AU - Nelson, Margret O

AU - Nielsen, Craig

AU - Norene, David L

AU - O'Connor, David H

AU - Ojikutu, Bisola O

AU - Okulicz, Jason

AU - Oladehin, Olakunle O

AU - Oldfield, Edward C

AU - Olender, Susan A

AU - Ostrowski, Mario

AU - Owen, William F

AU - Pae, Eunice

AU - Parsonnet, Jeffrey

AU - Pavlatos, Andrew M

AU - Perlmutter, Aaron M

AU - Pierce, Michael N

AU - Pincus, Jonathan M

AU - Pisani, Leandro

AU - Price, Lawrence Jay

AU - Proia, Laurie

AU - Prokesch, [Unbekannt]

PY - 2010

Y1 - 2010

N2 - Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection.

AB - Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection.

KW - Humans

KW - Cohort Studies

KW - Disease Progression

KW - Logistic Models

KW - Viral Load

KW - Models, Molecular

KW - Genome-Wide Association Study

KW - Polymorphism, Single Nucleotide

KW - Alleles

KW - Protein Conformation

KW - Haplotypes

KW - Immunity, Innate

KW - European Continental Ancestry Group/genetics

KW - CD8-Positive T-Lymphocytes/immunology

KW - African Americans/genetics

KW - Amino Acids/physiology

KW - Antigen Presentation

KW - Genes, MHC Class I

KW - HIV Antigens/immunology

KW - HIV Infections/ethnology/genetics/immunology/virology

KW - HIV Long-Term Survivors

KW - HIV-1/immunology

KW - HLA-A Antigens/chemistry/genetics/immunology/metabolism

KW - HLA-B Antigens/chemistry/genetics/immunology/metabolism

KW - HLA-C Antigens/chemistry/genetics/immunology/metabolism

KW - Hispanic Americans/genetics

KW - Humans

KW - Cohort Studies

KW - Disease Progression

KW - Logistic Models

KW - Viral Load

KW - Models, Molecular

KW - Genome-Wide Association Study

KW - Polymorphism, Single Nucleotide

KW - Alleles

KW - Protein Conformation

KW - Haplotypes

KW - Immunity, Innate

KW - European Continental Ancestry Group/genetics

KW - CD8-Positive T-Lymphocytes/immunology

KW - African Americans/genetics

KW - Amino Acids/physiology

KW - Antigen Presentation

KW - Genes, MHC Class I

KW - HIV Antigens/immunology

KW - HIV Infections/ethnology/genetics/immunology/virology

KW - HIV Long-Term Survivors

KW - HIV-1/immunology

KW - HLA-A Antigens/chemistry/genetics/immunology/metabolism

KW - HLA-B Antigens/chemistry/genetics/immunology/metabolism

KW - HLA-C Antigens/chemistry/genetics/immunology/metabolism

KW - Hispanic Americans/genetics

M3 - SCORING: Journal article

VL - 330

SP - 1551

EP - 1557

JO - SCIENCE

JF - SCIENCE

SN - 0036-8075

IS - 6010

M1 - 6010

ER -