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The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches

Standard

The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches. / Mineo, Marco; Ricklefs, Franz; Rooj, Arun K; Lyons, Shawn M; Ivanov, Pavel; Ansari, Khairul I; Nakano, Ichiro; Chiocca, E Antonio; Godlewski, Jakub; Bronisz, Agnieszka.

In: CELL REP, Vol. 15, No. 11, 14.06.2016, p. 2500-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mineo, M, Ricklefs, F, Rooj, AK, Lyons, SM, Ivanov, P, Ansari, KI, Nakano, I, Chiocca, EA, Godlewski, J & Bronisz, A 2016, 'The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches', CELL REP, vol. 15, no. 11, pp. 2500-9. https://doi.org/10.1016/j.celrep.2016.05.018

APA

Mineo, M., Ricklefs, F., Rooj, A. K., Lyons, S. M., Ivanov, P., Ansari, K. I., Nakano, I., Chiocca, E. A., Godlewski, J., & Bronisz, A. (2016). The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches. CELL REP, 15(11), 2500-9. https://doi.org/10.1016/j.celrep.2016.05.018

Vancouver

Mineo M, Ricklefs F, Rooj AK, Lyons SM, Ivanov P, Ansari KI et al. The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches. CELL REP. 2016 Jun 14;15(11):2500-9. https://doi.org/10.1016/j.celrep.2016.05.018

Bibtex

@article{36dd2bdafe75438f85618a75d11ace4f,
title = "The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches",
abstract = "Long non-coding RNAs (lncRNAs) have an undefined role in the pathobiology of glioblastoma multiforme (GBM). These tumors are genetically and phenotypically heterogeneous with transcriptome subtype-specific GBM stem-like cells (GSCs) that adapt to the brain tumor microenvironment, including hypoxic niches. We identified hypoxia-inducible factor 1 alpha-antisense RNA 2 (HIF1A-AS2) as a subtype-specific hypoxia-inducible lncRNA, upregulated in mesenchymal GSCs. Its deregulation affects GSC growth, self-renewal, and hypoxia-dependent molecular reprogramming. Among the HIF1A-AS2 interactome, IGF2BP2 and DHX9 were identified as direct partners. This association was needed for maintenance of expression of their target gene, HMGA1. Downregulation of HIF1A-AS2 led to delayed growth of mesenchymal GSC tumors, survival benefits, and impaired expression of HMGA1 in vivo. Our data demonstrate that HIF1A-AS2 contributes to GSCs' speciation and adaptation to hypoxia within the tumor microenvironment, acting directly through its interactome and targets and indirectly by modulating responses to hypoxic stress depending on the subtype-specific genetic context.",
keywords = "Journal Article",
author = "Marco Mineo and Franz Ricklefs and Rooj, {Arun K} and Lyons, {Shawn M} and Pavel Ivanov and Ansari, {Khairul I} and Ichiro Nakano and Chiocca, {E Antonio} and Jakub Godlewski and Agnieszka Bronisz",
note = "Copyright {\textcopyright} 2016 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2016",
month = jun,
day = "14",
doi = "10.1016/j.celrep.2016.05.018",
language = "English",
volume = "15",
pages = "2500--9",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches

AU - Mineo, Marco

AU - Ricklefs, Franz

AU - Rooj, Arun K

AU - Lyons, Shawn M

AU - Ivanov, Pavel

AU - Ansari, Khairul I

AU - Nakano, Ichiro

AU - Chiocca, E Antonio

AU - Godlewski, Jakub

AU - Bronisz, Agnieszka

N1 - Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2016/6/14

Y1 - 2016/6/14

N2 - Long non-coding RNAs (lncRNAs) have an undefined role in the pathobiology of glioblastoma multiforme (GBM). These tumors are genetically and phenotypically heterogeneous with transcriptome subtype-specific GBM stem-like cells (GSCs) that adapt to the brain tumor microenvironment, including hypoxic niches. We identified hypoxia-inducible factor 1 alpha-antisense RNA 2 (HIF1A-AS2) as a subtype-specific hypoxia-inducible lncRNA, upregulated in mesenchymal GSCs. Its deregulation affects GSC growth, self-renewal, and hypoxia-dependent molecular reprogramming. Among the HIF1A-AS2 interactome, IGF2BP2 and DHX9 were identified as direct partners. This association was needed for maintenance of expression of their target gene, HMGA1. Downregulation of HIF1A-AS2 led to delayed growth of mesenchymal GSC tumors, survival benefits, and impaired expression of HMGA1 in vivo. Our data demonstrate that HIF1A-AS2 contributes to GSCs' speciation and adaptation to hypoxia within the tumor microenvironment, acting directly through its interactome and targets and indirectly by modulating responses to hypoxic stress depending on the subtype-specific genetic context.

AB - Long non-coding RNAs (lncRNAs) have an undefined role in the pathobiology of glioblastoma multiforme (GBM). These tumors are genetically and phenotypically heterogeneous with transcriptome subtype-specific GBM stem-like cells (GSCs) that adapt to the brain tumor microenvironment, including hypoxic niches. We identified hypoxia-inducible factor 1 alpha-antisense RNA 2 (HIF1A-AS2) as a subtype-specific hypoxia-inducible lncRNA, upregulated in mesenchymal GSCs. Its deregulation affects GSC growth, self-renewal, and hypoxia-dependent molecular reprogramming. Among the HIF1A-AS2 interactome, IGF2BP2 and DHX9 were identified as direct partners. This association was needed for maintenance of expression of their target gene, HMGA1. Downregulation of HIF1A-AS2 led to delayed growth of mesenchymal GSC tumors, survival benefits, and impaired expression of HMGA1 in vivo. Our data demonstrate that HIF1A-AS2 contributes to GSCs' speciation and adaptation to hypoxia within the tumor microenvironment, acting directly through its interactome and targets and indirectly by modulating responses to hypoxic stress depending on the subtype-specific genetic context.

KW - Journal Article

U2 - 10.1016/j.celrep.2016.05.018

DO - 10.1016/j.celrep.2016.05.018

M3 - SCORING: Journal article

C2 - 27264189

VL - 15

SP - 2500

EP - 2509

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 11

ER -