The Locus Coeruleus Is a Complex and Differentiated Neuromodulatory System

Nelson K Totah; Ricardo M Neves; Stefano Panzeri; Nikos K Logothetis; Oxana Eschenko

doi:10.1016/j.neuron.2018.07.037

The Locus Coeruleus Is a Complex and Differentiated Neuromodulatory System

Standard

The Locus Coeruleus Is a Complex and Differentiated Neuromodulatory System. / Totah, Nelson K; Neves, Ricardo M; Panzeri, Stefano; Logothetis, Nikos K; Eschenko, Oxana.

In: NEURON, Vol. 99, No. 5, 05.09.2018, p. 1055-1068.e6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Totah, NK, Neves, RM, Panzeri, S, Logothetis, NK & Eschenko, O 2018, 'The Locus Coeruleus Is a Complex and Differentiated Neuromodulatory System', NEURON, vol. 99, no. 5, pp. 1055-1068.e6. https://doi.org/10.1016/j.neuron.2018.07.037

APA

Totah, N. K., Neves, R. M., Panzeri, S., Logothetis, N. K., & Eschenko, O. (2018). The Locus Coeruleus Is a Complex and Differentiated Neuromodulatory System. NEURON, 99(5), 1055-1068.e6. https://doi.org/10.1016/j.neuron.2018.07.037

Vancouver

Totah NK, Neves RM, Panzeri S, Logothetis NK, Eschenko O. The Locus Coeruleus Is a Complex and Differentiated Neuromodulatory System. NEURON. 2018 Sep 5;99(5):1055-1068.e6. https://doi.org/10.1016/j.neuron.2018.07.037

Bibtex

@article{36e97e4017ca4aaab291b28de3c6788a,

title = "The Locus Coeruleus Is a Complex and Differentiated Neuromodulatory System",

abstract = "Diffuse projections of locus coeruleus (LC) neurons and evidence of synchronous spiking have long been perceived as features of global neuromodulation. Recent studies demonstrated the possibility of targeted modulation by subsets of LC neurons. Non-global neuromodulation depends on target specificity and the differentiated spatiotemporal dynamics within LC. Here, we characterized interactions between 3,164 LC cell pairs in the rat LC under urethane anesthesia. Spike count correlations were near zero and only a small proportion of unit pairs had synchronized spontaneous (15%) or evoked (16%) discharge. We identified infra-slow (0.01-1 Hz) fluctuations of LC unit spike rate, which were also asynchronous across the population. Despite overall sparse population synchrony, we report the existence of LC ensembles and relate them to forebrain projection targets. We also show that spike waveform width was related to ensemble membership, propensity for synchronization, and interactions with cortex. Our findings suggest a partly differentiated and target-specific noradrenergic signal.",

keywords = "Action Potentials/physiology, Animals, Cell Differentiation/physiology, Electric Stimulation/methods, Locus Coeruleus/cytology, Male, Neurons/physiology, Random Allocation, Rats, Rats, Sprague-Dawley",

author = "Totah, {Nelson K} and Neves, {Ricardo M} and Stefano Panzeri and Logothetis, {Nikos K} and Oxana Eschenko",

year = "2018",

month = sep,

day = "5",

doi = "10.1016/j.neuron.2018.07.037",

language = "English",

volume = "99",

pages = "1055--1068.e6",

journal = "NEURON",

issn = "0896-6273",

publisher = "Cell Press",

number = "5",

}

RIS

TY - JOUR

T1 - The Locus Coeruleus Is a Complex and Differentiated Neuromodulatory System

AU - Totah, Nelson K

AU - Neves, Ricardo M

AU - Panzeri, Stefano

AU - Logothetis, Nikos K

AU - Eschenko, Oxana

PY - 2018/9/5

Y1 - 2018/9/5

N2 - Diffuse projections of locus coeruleus (LC) neurons and evidence of synchronous spiking have long been perceived as features of global neuromodulation. Recent studies demonstrated the possibility of targeted modulation by subsets of LC neurons. Non-global neuromodulation depends on target specificity and the differentiated spatiotemporal dynamics within LC. Here, we characterized interactions between 3,164 LC cell pairs in the rat LC under urethane anesthesia. Spike count correlations were near zero and only a small proportion of unit pairs had synchronized spontaneous (15%) or evoked (16%) discharge. We identified infra-slow (0.01-1 Hz) fluctuations of LC unit spike rate, which were also asynchronous across the population. Despite overall sparse population synchrony, we report the existence of LC ensembles and relate them to forebrain projection targets. We also show that spike waveform width was related to ensemble membership, propensity for synchronization, and interactions with cortex. Our findings suggest a partly differentiated and target-specific noradrenergic signal.

AB - Diffuse projections of locus coeruleus (LC) neurons and evidence of synchronous spiking have long been perceived as features of global neuromodulation. Recent studies demonstrated the possibility of targeted modulation by subsets of LC neurons. Non-global neuromodulation depends on target specificity and the differentiated spatiotemporal dynamics within LC. Here, we characterized interactions between 3,164 LC cell pairs in the rat LC under urethane anesthesia. Spike count correlations were near zero and only a small proportion of unit pairs had synchronized spontaneous (15%) or evoked (16%) discharge. We identified infra-slow (0.01-1 Hz) fluctuations of LC unit spike rate, which were also asynchronous across the population. Despite overall sparse population synchrony, we report the existence of LC ensembles and relate them to forebrain projection targets. We also show that spike waveform width was related to ensemble membership, propensity for synchronization, and interactions with cortex. Our findings suggest a partly differentiated and target-specific noradrenergic signal.

KW - Action Potentials/physiology

KW - Animals

KW - Cell Differentiation/physiology

KW - Electric Stimulation/methods

KW - Locus Coeruleus/cytology

KW - Male

KW - Neurons/physiology

KW - Random Allocation

KW - Rats

KW - Rats, Sprague-Dawley

U2 - 10.1016/j.neuron.2018.07.037

DO - 10.1016/j.neuron.2018.07.037

M3 - SCORING: Journal article

C2 - 30122373

VL - 99

SP - 1055-1068.e6

JO - NEURON

JF - NEURON

SN - 0896-6273

IS - 5

ER -