The landscape of metastatic progression patterns across major human cancers

Jan Budczies; Moritz von Winterfeld; Frederick Klauschen; Michael Bockmayr; Jochen K Lennerz; Carsten Denkert; Thomas Wolf; Arne Warth; Manfred Dietel; Ioannis Anagnostopoulos; Wilko Weichert; Daniel Wittschieber; Albrecht Stenzinger

doi:10.18632/oncotarget.2677

The landscape of metastatic progression patterns across major human cancers

Standard

The landscape of metastatic progression patterns across major human cancers. / Budczies, Jan; von Winterfeld, Moritz; Klauschen, Frederick; Bockmayr, Michael; Lennerz, Jochen K; Denkert, Carsten; Wolf, Thomas; Warth, Arne; Dietel, Manfred; Anagnostopoulos, Ioannis; Weichert, Wilko; Wittschieber, Daniel; Stenzinger, Albrecht.

In: ONCOTARGET, Vol. 6, No. 1, 01.01.2015, p. 570-83.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Budczies, J, von Winterfeld, M, Klauschen, F, Bockmayr, M, Lennerz, JK, Denkert, C, Wolf, T, Warth, A, Dietel, M, Anagnostopoulos, I, Weichert, W, Wittschieber, D & Stenzinger, A 2015, 'The landscape of metastatic progression patterns across major human cancers', ONCOTARGET, vol. 6, no. 1, pp. 570-83. https://doi.org/10.18632/oncotarget.2677

APA

Budczies, J., von Winterfeld, M., Klauschen, F., Bockmayr, M., Lennerz, J. K., Denkert, C., Wolf, T., Warth, A., Dietel, M., Anagnostopoulos, I., Weichert, W., Wittschieber, D., & Stenzinger, A. (2015). The landscape of metastatic progression patterns across major human cancers. ONCOTARGET, 6(1), 570-83. https://doi.org/10.18632/oncotarget.2677

Vancouver

Budczies J, von Winterfeld M, Klauschen F, Bockmayr M, Lennerz JK, Denkert C et al. The landscape of metastatic progression patterns across major human cancers. ONCOTARGET. 2015 Jan 1;6(1):570-83. https://doi.org/10.18632/oncotarget.2677

Bibtex

@article{149f304a479f4556b546a07eff732e95,

title = "The landscape of metastatic progression patterns across major human cancers",

abstract = "The majority of patients with solid malignancies die from metastatic burden. However, our current understanding of the mechanisms and resulting patterns of dissemination is limited. Here, we analyzed patterns of metastatic progression across 16 major cancer types in a cohort of 1008 patients with metastatic cancer autopsied between 2000 and 2013 to assess cancer specific progression patterns of disease and related risk predictions. The frequency and location of metastases were evaluated in and across 1) 16 major cancers, 2) smoking- and non-smoking-related cancers and 3) adeno- and squamous cell carcinoma. Associations between primary and secondary sites were analyzed by the fractional and the relative risk methods. We detected significantly different cancer specific patterns of metastatic progression with specific relative risk profiles for secondary site involvement. Histology and smoking etiology influenced these patterns. Backward analysis showed that metastatic patterns help to predict unknown primary sites. Solid malignancies maintain a unique and recurrent organ tropism to specific secondary sites which does not appear to be strongly influenced by advances in cancer medicine as shown by comparison with previous data sets. The delineated landscape of metastatic progression patterns is a comprehensive data resource to both clinical and basic scientists which aids fostering new hypotheses for cancer research and cancer therapies.",

keywords = "Adenocarcinoma, Carcinoma, Squamous Cell, Cluster Analysis, Disease Progression, Female, Humans, Male, Neoplasm Metastasis, Neoplasms, Retrospective Studies, Risk Factors, Smoking, Journal Article",

author = "Jan Budczies and {von Winterfeld}, Moritz and Frederick Klauschen and Michael Bockmayr and Lennerz, {Jochen K} and Carsten Denkert and Thomas Wolf and Arne Warth and Manfred Dietel and Ioannis Anagnostopoulos and Wilko Weichert and Daniel Wittschieber and Albrecht Stenzinger",

year = "2015",

month = jan,

day = "1",

doi = "10.18632/oncotarget.2677",

language = "English",

volume = "6",

pages = "570--83",

journal = "ONCOTARGET",

issn = "1949-2553",

publisher = "IMPACT JOURNALS LLC",

number = "1",

}

RIS

TY - JOUR

T1 - The landscape of metastatic progression patterns across major human cancers

AU - Budczies, Jan

AU - von Winterfeld, Moritz

AU - Klauschen, Frederick

AU - Bockmayr, Michael

AU - Lennerz, Jochen K

AU - Denkert, Carsten

AU - Wolf, Thomas

AU - Warth, Arne

AU - Dietel, Manfred

AU - Anagnostopoulos, Ioannis

AU - Weichert, Wilko

AU - Wittschieber, Daniel

AU - Stenzinger, Albrecht

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The majority of patients with solid malignancies die from metastatic burden. However, our current understanding of the mechanisms and resulting patterns of dissemination is limited. Here, we analyzed patterns of metastatic progression across 16 major cancer types in a cohort of 1008 patients with metastatic cancer autopsied between 2000 and 2013 to assess cancer specific progression patterns of disease and related risk predictions. The frequency and location of metastases were evaluated in and across 1) 16 major cancers, 2) smoking- and non-smoking-related cancers and 3) adeno- and squamous cell carcinoma. Associations between primary and secondary sites were analyzed by the fractional and the relative risk methods. We detected significantly different cancer specific patterns of metastatic progression with specific relative risk profiles for secondary site involvement. Histology and smoking etiology influenced these patterns. Backward analysis showed that metastatic patterns help to predict unknown primary sites. Solid malignancies maintain a unique and recurrent organ tropism to specific secondary sites which does not appear to be strongly influenced by advances in cancer medicine as shown by comparison with previous data sets. The delineated landscape of metastatic progression patterns is a comprehensive data resource to both clinical and basic scientists which aids fostering new hypotheses for cancer research and cancer therapies.

AB - The majority of patients with solid malignancies die from metastatic burden. However, our current understanding of the mechanisms and resulting patterns of dissemination is limited. Here, we analyzed patterns of metastatic progression across 16 major cancer types in a cohort of 1008 patients with metastatic cancer autopsied between 2000 and 2013 to assess cancer specific progression patterns of disease and related risk predictions. The frequency and location of metastases were evaluated in and across 1) 16 major cancers, 2) smoking- and non-smoking-related cancers and 3) adeno- and squamous cell carcinoma. Associations between primary and secondary sites were analyzed by the fractional and the relative risk methods. We detected significantly different cancer specific patterns of metastatic progression with specific relative risk profiles for secondary site involvement. Histology and smoking etiology influenced these patterns. Backward analysis showed that metastatic patterns help to predict unknown primary sites. Solid malignancies maintain a unique and recurrent organ tropism to specific secondary sites which does not appear to be strongly influenced by advances in cancer medicine as shown by comparison with previous data sets. The delineated landscape of metastatic progression patterns is a comprehensive data resource to both clinical and basic scientists which aids fostering new hypotheses for cancer research and cancer therapies.

KW - Adenocarcinoma

KW - Carcinoma, Squamous Cell

KW - Cluster Analysis

KW - Disease Progression

KW - Female

KW - Humans

KW - Male

KW - Neoplasm Metastasis

KW - Neoplasms

KW - Retrospective Studies

KW - Risk Factors

KW - Smoking

KW - Journal Article

U2 - 10.18632/oncotarget.2677

DO - 10.18632/oncotarget.2677

M3 - SCORING: Journal article

C2 - 25402435

VL - 6

SP - 570

EP - 583

JO - ONCOTARGET

JF - ONCOTARGET

SN - 1949-2553

IS - 1

ER -