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The kinesin KIF21B participates in the cell surface delivery of γ2 subunit-containing GABAA receptors

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The kinesin KIF21B participates in the cell surface delivery of γ2 subunit-containing GABAA receptors. / Labonté, Dorthe; Thies, Edda; Kneussel, Matthias.

In: EUR J CELL BIOL, Vol. 93, No. 8-9, 31.08.2014, p. 338-46.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Labonté, D, Thies, E & Kneussel, M 2014, 'The kinesin KIF21B participates in the cell surface delivery of γ2 subunit-containing GABAA receptors', EUR J CELL BIOL, vol. 93, no. 8-9, pp. 338-46. https://doi.org/10.1016/j.ejcb.2014.07.007

APA

Labonté, D., Thies, E., & Kneussel, M. (2014). The kinesin KIF21B participates in the cell surface delivery of γ2 subunit-containing GABAA receptors. EUR J CELL BIOL, 93(8-9), 338-46. https://doi.org/10.1016/j.ejcb.2014.07.007

Vancouver

Labonté D, Thies E, Kneussel M. The kinesin KIF21B participates in the cell surface delivery of γ2 subunit-containing GABAA receptors. EUR J CELL BIOL. 2014 Aug 31;93(8-9):338-46. https://doi.org/10.1016/j.ejcb.2014.07.007

Bibtex

@article{14b63e32b4a54d608c75942b0ba3ea5c,
title = "The kinesin KIF21B participates in the cell surface delivery of γ2 subunit-containing GABAA receptors",
abstract = "KIF21B, a kinesin family (KIF) protein, is a plus end-directed microtubule motor. The KIF21B gene is highly expressed in neuronal tissue and spleen and is a susceptibility locus for multiple sclerosis. KIF21B motility is regulated through TRIM3, a member of the cytoskeleton-associated-recycling or transport (CART) complex, involved in vesicular receptor recycling. Here we show that the GABAA receptor γ2-subunit co-precipitates and co-localizes with KIF21B in cultured hippocampal neurons. Knockdown of KIF21B gene expression through small hairpin (sh) RNA reduces the number of γ2-subunit-containing GABAA receptor (GABAARs) clusters in neurites and at the cell surface. Our data suggest that KIF21B participates in the delivery of GABAAR transport vesicles into dendrites.",
author = "Dorthe Labont{\'e} and Edda Thies and Matthias Kneussel",
note = "Copyright {\textcopyright} 2014 The Authors. Published by Elsevier GmbH.. All rights reserved.",
year = "2014",
month = aug,
day = "31",
doi = "10.1016/j.ejcb.2014.07.007",
language = "English",
volume = "93",
pages = "338--46",
journal = "EUR J CELL BIOL",
issn = "0171-9335",
publisher = "Urban und Fischer Verlag GmbH und Co. KG",
number = "8-9",

}

RIS

TY - JOUR

T1 - The kinesin KIF21B participates in the cell surface delivery of γ2 subunit-containing GABAA receptors

AU - Labonté, Dorthe

AU - Thies, Edda

AU - Kneussel, Matthias

N1 - Copyright © 2014 The Authors. Published by Elsevier GmbH.. All rights reserved.

PY - 2014/8/31

Y1 - 2014/8/31

N2 - KIF21B, a kinesin family (KIF) protein, is a plus end-directed microtubule motor. The KIF21B gene is highly expressed in neuronal tissue and spleen and is a susceptibility locus for multiple sclerosis. KIF21B motility is regulated through TRIM3, a member of the cytoskeleton-associated-recycling or transport (CART) complex, involved in vesicular receptor recycling. Here we show that the GABAA receptor γ2-subunit co-precipitates and co-localizes with KIF21B in cultured hippocampal neurons. Knockdown of KIF21B gene expression through small hairpin (sh) RNA reduces the number of γ2-subunit-containing GABAA receptor (GABAARs) clusters in neurites and at the cell surface. Our data suggest that KIF21B participates in the delivery of GABAAR transport vesicles into dendrites.

AB - KIF21B, a kinesin family (KIF) protein, is a plus end-directed microtubule motor. The KIF21B gene is highly expressed in neuronal tissue and spleen and is a susceptibility locus for multiple sclerosis. KIF21B motility is regulated through TRIM3, a member of the cytoskeleton-associated-recycling or transport (CART) complex, involved in vesicular receptor recycling. Here we show that the GABAA receptor γ2-subunit co-precipitates and co-localizes with KIF21B in cultured hippocampal neurons. Knockdown of KIF21B gene expression through small hairpin (sh) RNA reduces the number of γ2-subunit-containing GABAA receptor (GABAARs) clusters in neurites and at the cell surface. Our data suggest that KIF21B participates in the delivery of GABAAR transport vesicles into dendrites.

U2 - 10.1016/j.ejcb.2014.07.007

DO - 10.1016/j.ejcb.2014.07.007

M3 - SCORING: Journal article

C2 - 25172774

VL - 93

SP - 338

EP - 346

JO - EUR J CELL BIOL

JF - EUR J CELL BIOL

SN - 0171-9335

IS - 8-9

ER -