The intestinal and biliary microbiome in autoimmune liver disease-current evidence and concepts

Timur Liwinski; Melina Heinemann; Christoph Schramm

doi:10.1007/s00281-022-00936-6

The intestinal and biliary microbiome in autoimmune liver disease-current evidence and concepts

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The intestinal and biliary microbiome in autoimmune liver disease-current evidence and concepts. / Liwinski, Timur; Heinemann, Melina ; Schramm, Christoph.

In: SEMIN IMMUNOPATHOL, Vol. 44, No. 4, 07.2022, p. 485-507.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Liwinski, T, Heinemann, M & Schramm, C 2022, 'The intestinal and biliary microbiome in autoimmune liver disease-current evidence and concepts', SEMIN IMMUNOPATHOL, vol. 44, no. 4, pp. 485-507. https://doi.org/10.1007/s00281-022-00936-6

APA

Liwinski, T., Heinemann, M., & Schramm, C. (2022). The intestinal and biliary microbiome in autoimmune liver disease-current evidence and concepts. SEMIN IMMUNOPATHOL, 44(4), 485-507. https://doi.org/10.1007/s00281-022-00936-6

Vancouver

Liwinski T, Heinemann M , Schramm C. The intestinal and biliary microbiome in autoimmune liver disease-current evidence and concepts. SEMIN IMMUNOPATHOL. 2022 Jul;44(4):485-507. https://doi.org/10.1007/s00281-022-00936-6

Bibtex

@article{b95d00a164f24c1b9a77861c5e6d6dd3,

title = "The intestinal and biliary microbiome in autoimmune liver disease-current evidence and concepts",

abstract = "Autoimmune liver diseases are a group of immune-mediated liver diseases with three distinct entities, including autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis. The interplay of genetic and environmental factors leads to the breakdown of self-tolerance, resulting in hyper-responsiveness, and auto-aggressive immune activation. Emerging evidence links autoimmune liver diseases with alterations of the commensal microbiome configuration and aberrant immune system activation by microbial signals, mainly via the gut-liver axis. Thus, the microbiome is a new frontier to deepen the pathogenetic understanding, uncover biomarkers, and inspire innovative treatments. Herein, we review the current evidence on the role of the microbiome in autoimmune liver diseases from both clinical and basic research. We highlight recent achievements and also bottlenecks and limitations. Moreover, we give an outlook on future developments and potential for clinical applications.",

keywords = "Autoimmune Diseases/etiology, Hepatitis, Autoimmune/etiology, Humans, Liver, Liver Diseases/etiology, Microbiota",

author = "Timur Liwinski and Melina Heinemann and Christoph Schramm",

note = "{\textcopyright} 2022. The Author(s).",

year = "2022",

month = jul,

doi = "10.1007/s00281-022-00936-6",

language = "English",

volume = "44",

pages = "485--507",

journal = "SEMIN IMMUNOPATHOL",

issn = "1863-2297",

publisher = "Springer",

number = "4",

}

RIS

TY - JOUR

T1 - The intestinal and biliary microbiome in autoimmune liver disease-current evidence and concepts

AU - Liwinski, Timur

AU - Heinemann, Melina

AU - Schramm, Christoph

PY - 2022/7

Y1 - 2022/7

N2 - Autoimmune liver diseases are a group of immune-mediated liver diseases with three distinct entities, including autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis. The interplay of genetic and environmental factors leads to the breakdown of self-tolerance, resulting in hyper-responsiveness, and auto-aggressive immune activation. Emerging evidence links autoimmune liver diseases with alterations of the commensal microbiome configuration and aberrant immune system activation by microbial signals, mainly via the gut-liver axis. Thus, the microbiome is a new frontier to deepen the pathogenetic understanding, uncover biomarkers, and inspire innovative treatments. Herein, we review the current evidence on the role of the microbiome in autoimmune liver diseases from both clinical and basic research. We highlight recent achievements and also bottlenecks and limitations. Moreover, we give an outlook on future developments and potential for clinical applications.

AB - Autoimmune liver diseases are a group of immune-mediated liver diseases with three distinct entities, including autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis. The interplay of genetic and environmental factors leads to the breakdown of self-tolerance, resulting in hyper-responsiveness, and auto-aggressive immune activation. Emerging evidence links autoimmune liver diseases with alterations of the commensal microbiome configuration and aberrant immune system activation by microbial signals, mainly via the gut-liver axis. Thus, the microbiome is a new frontier to deepen the pathogenetic understanding, uncover biomarkers, and inspire innovative treatments. Herein, we review the current evidence on the role of the microbiome in autoimmune liver diseases from both clinical and basic research. We highlight recent achievements and also bottlenecks and limitations. Moreover, we give an outlook on future developments and potential for clinical applications.

KW - Autoimmune Diseases/etiology

KW - Hepatitis, Autoimmune/etiology

KW - Humans

KW - Liver

KW - Liver Diseases/etiology

KW - Microbiota

U2 - 10.1007/s00281-022-00936-6

DO - 10.1007/s00281-022-00936-6

M3 - SCORING: Review article

C2 - 35536431

VL - 44

SP - 485

EP - 507

JO - SEMIN IMMUNOPATHOL

JF - SEMIN IMMUNOPATHOL

SN - 1863-2297

IS - 4

ER -