The interrelationship between diabetes mellitus and peripheral arterial disease
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The interrelationship between diabetes mellitus and peripheral arterial disease. / Stoberock, Konstanze; Kaschwich, Mark; Nicolay, Shiva Sophia; Mahmoud, Nazeh; Heidemann, Franziska; Rieß, Henrik C; Debus, Eike Sebastian; Behrendt, Christian-Alexander.
In: VASA, Vol. 50, No. 5, 09.2021, p. 323-330.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - The interrelationship between diabetes mellitus and peripheral arterial disease
AU - Stoberock, Konstanze
AU - Kaschwich, Mark
AU - Nicolay, Shiva Sophia
AU - Mahmoud, Nazeh
AU - Heidemann, Franziska
AU - Rieß, Henrik C
AU - Debus, Eike Sebastian
AU - Behrendt, Christian-Alexander
PY - 2021/9
Y1 - 2021/9
N2 - This systematic review examined the interrelationship between concomitant diabetes mellitus (DM) and peripheral arterial disease (PAD). The objective was to determine differences in the prevalence as well as in the outcomes in diabetic vs. non-diabetic PAD patients. The current review followed a study protocol that was published online in German in 2017. The search included societal practice guidelines, consensus statements, systematic reviews, meta-analyses, and observational studies published from 2007 to 2020 reporting symptomatic PAD and concomitant DM in patients undergoing invasive open-surgical and endovascular revascularizations. German and English literature has been considered. Eligibility criteria were verified by three independent reviewers. Disagreement was resolved by discussion involving a fourth reviewer. 580 articles were identified. After exclusion of non-eligible studies, 61 papers from 30 countries remained, respectively 850,072 patients. The included studies showed that PAD prevalence differed between diabetic vs. non-diabetic populations (20-50% vs. 10-26%), and further by age, gender, ethnicity, duration of existing diabetes, and geographic region. The included studies revealed worse outcomes regarding perioperative complications, amputation rate, and mortality rate in diabetic patients when compared to non-diabetic patients. In both groups, the amputation rates decreased during the research period. This review emphasizes an interrelationship between PAD and DM. To improve the outcomes, early detection of PAD in diabetic patients, and vice versa, should be recommended. The results of this systematic review may help to update societal practice guidelines.
AB - This systematic review examined the interrelationship between concomitant diabetes mellitus (DM) and peripheral arterial disease (PAD). The objective was to determine differences in the prevalence as well as in the outcomes in diabetic vs. non-diabetic PAD patients. The current review followed a study protocol that was published online in German in 2017. The search included societal practice guidelines, consensus statements, systematic reviews, meta-analyses, and observational studies published from 2007 to 2020 reporting symptomatic PAD and concomitant DM in patients undergoing invasive open-surgical and endovascular revascularizations. German and English literature has been considered. Eligibility criteria were verified by three independent reviewers. Disagreement was resolved by discussion involving a fourth reviewer. 580 articles were identified. After exclusion of non-eligible studies, 61 papers from 30 countries remained, respectively 850,072 patients. The included studies showed that PAD prevalence differed between diabetic vs. non-diabetic populations (20-50% vs. 10-26%), and further by age, gender, ethnicity, duration of existing diabetes, and geographic region. The included studies revealed worse outcomes regarding perioperative complications, amputation rate, and mortality rate in diabetic patients when compared to non-diabetic patients. In both groups, the amputation rates decreased during the research period. This review emphasizes an interrelationship between PAD and DM. To improve the outcomes, early detection of PAD in diabetic patients, and vice versa, should be recommended. The results of this systematic review may help to update societal practice guidelines.
KW - Amputation
KW - Diabetes Mellitus/diagnosis
KW - Humans
KW - Peripheral Arterial Disease/diagnosis
KW - Vascular Surgical Procedures
U2 - 10.1024/0301-1526/a000925
DO - 10.1024/0301-1526/a000925
M3 - SCORING: Review article
C2 - 33175668
VL - 50
SP - 323
EP - 330
JO - VASA
JF - VASA
SN - 0301-1526
IS - 5
ER -