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The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance

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The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance. / Dahl, Martin J; Bachman, Shelby L; Dutt, Shubir; Düzel, Sandra; Bodammer, Nils C; Lindenberger, Ulman; Kühn, Simone; Werkle-Bergner, Markus; Mather, Mara.

In: NATURE AGING, Vol. 3, No. 9, 09.2023, p. 1128-1143.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dahl, MJ, Bachman, SL, Dutt, S, Düzel, S, Bodammer, NC, Lindenberger, U, Kühn, S, Werkle-Bergner, M & Mather, M 2023, 'The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance', NATURE AGING, vol. 3, no. 9, pp. 1128-1143. https://doi.org/10.1038/s43587-023-00469-z

APA

Dahl, M. J., Bachman, S. L., Dutt, S., Düzel, S., Bodammer, N. C., Lindenberger, U., Kühn, S., Werkle-Bergner, M., & Mather, M. (2023). The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance. NATURE AGING, 3(9), 1128-1143. https://doi.org/10.1038/s43587-023-00469-z

Vancouver

Dahl MJ, Bachman SL, Dutt S, Düzel S, Bodammer NC, Lindenberger U et al. The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance. NATURE AGING. 2023 Sep;3(9):1128-1143. https://doi.org/10.1038/s43587-023-00469-z

Bibtex

@article{52ab54ebdf48450d97585ba813527e39,
title = "The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance",
abstract = "Changes in dopaminergic neuromodulation play a key role in adult memory decline. Recent research has also implicated noradrenaline in shaping late-life memory. However, it is unclear whether these two neuromodulators have distinct roles in age-related cognitive changes. Here, combining longitudinal MRI of the dopaminergic substantia nigra-ventral tegmental area (SN-VTA) and noradrenergic locus coeruleus (LC) in younger (n = 69) and older (n = 251) adults, we found that dopaminergic and noradrenergic integrity are differentially associated with memory performance. While LC integrity was related to better episodic memory across several tasks, SN-VTA integrity was linked to working memory. Longitudinally, we found that older age was associated with more negative change in SN-VTA and LC integrity. Notably, changes in LC integrity reliably predicted future episodic memory. These differential associations of dopaminergic and noradrenergic nuclei with late-life cognitive decline have potential clinical utility, given their degeneration in several age-associated diseases.",
keywords = "Adult, Humans, Cognition, Locus Coeruleus/diagnostic imaging, Substantia Nigra, Cognitive Dysfunction, Dopamine, Norepinephrine",
author = "Dahl, {Martin J} and Bachman, {Shelby L} and Shubir Dutt and Sandra D{\"u}zel and Bodammer, {Nils C} and Ulman Lindenberger and Simone K{\"u}hn and Markus Werkle-Bergner and Mara Mather",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
month = sep,
doi = "10.1038/s43587-023-00469-z",
language = "English",
volume = "3",
pages = "1128--1143",
journal = "NATURE AGING",
issn = "2662-8465",
publisher = "Springer",
number = "9",

}

RIS

TY - JOUR

T1 - The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance

AU - Dahl, Martin J

AU - Bachman, Shelby L

AU - Dutt, Shubir

AU - Düzel, Sandra

AU - Bodammer, Nils C

AU - Lindenberger, Ulman

AU - Kühn, Simone

AU - Werkle-Bergner, Markus

AU - Mather, Mara

N1 - © 2023. The Author(s).

PY - 2023/9

Y1 - 2023/9

N2 - Changes in dopaminergic neuromodulation play a key role in adult memory decline. Recent research has also implicated noradrenaline in shaping late-life memory. However, it is unclear whether these two neuromodulators have distinct roles in age-related cognitive changes. Here, combining longitudinal MRI of the dopaminergic substantia nigra-ventral tegmental area (SN-VTA) and noradrenergic locus coeruleus (LC) in younger (n = 69) and older (n = 251) adults, we found that dopaminergic and noradrenergic integrity are differentially associated with memory performance. While LC integrity was related to better episodic memory across several tasks, SN-VTA integrity was linked to working memory. Longitudinally, we found that older age was associated with more negative change in SN-VTA and LC integrity. Notably, changes in LC integrity reliably predicted future episodic memory. These differential associations of dopaminergic and noradrenergic nuclei with late-life cognitive decline have potential clinical utility, given their degeneration in several age-associated diseases.

AB - Changes in dopaminergic neuromodulation play a key role in adult memory decline. Recent research has also implicated noradrenaline in shaping late-life memory. However, it is unclear whether these two neuromodulators have distinct roles in age-related cognitive changes. Here, combining longitudinal MRI of the dopaminergic substantia nigra-ventral tegmental area (SN-VTA) and noradrenergic locus coeruleus (LC) in younger (n = 69) and older (n = 251) adults, we found that dopaminergic and noradrenergic integrity are differentially associated with memory performance. While LC integrity was related to better episodic memory across several tasks, SN-VTA integrity was linked to working memory. Longitudinally, we found that older age was associated with more negative change in SN-VTA and LC integrity. Notably, changes in LC integrity reliably predicted future episodic memory. These differential associations of dopaminergic and noradrenergic nuclei with late-life cognitive decline have potential clinical utility, given their degeneration in several age-associated diseases.

KW - Adult

KW - Humans

KW - Cognition

KW - Locus Coeruleus/diagnostic imaging

KW - Substantia Nigra

KW - Cognitive Dysfunction

KW - Dopamine

KW - Norepinephrine

U2 - 10.1038/s43587-023-00469-z

DO - 10.1038/s43587-023-00469-z

M3 - SCORING: Journal article

C2 - 37653256

VL - 3

SP - 1128

EP - 1143

JO - NATURE AGING

JF - NATURE AGING

SN - 2662-8465

IS - 9

ER -