The innovative application of a novel bone adhesive for facial fracture osteosynthesis-in vitro and in vivo results
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The innovative application of a novel bone adhesive for facial fracture osteosynthesis-in vitro and in vivo results. / Smeets, Ralf; Endres, Kira; Stockbrink, Gereon; Hanken, Henning; Hermanns-Sachweh, Benita; Marx, Rudolf; Heiland, Max; Blessmann, Marco; Wolff, Klaus-Dietrich; Kolk, Andreas.
In: J BIOMED MATER RES A, Vol. 101, No. 7, 01.07.2013, p. 2058-66.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The innovative application of a novel bone adhesive for facial fracture osteosynthesis-in vitro and in vivo results
AU - Smeets, Ralf
AU - Endres, Kira
AU - Stockbrink, Gereon
AU - Hanken, Henning
AU - Hermanns-Sachweh, Benita
AU - Marx, Rudolf
AU - Heiland, Max
AU - Blessmann, Marco
AU - Wolff, Klaus-Dietrich
AU - Kolk, Andreas
N1 - Copyright © 2012 Wiley Periodicals, Inc.
PY - 2013/7/1
Y1 - 2013/7/1
N2 - This study evaluates a novel adhesive fixation technique to affix cortical bone fragments to osteosynthesis plates using common PMMA cement. This technique utilizes a new amphiphilic bone bonding agent adhering with both hydrophilic bone and hydrophobic PMMA cement. After in vitro biomechanical testing of the bonding strength with explanted bovine and rabbit calvarian bone samples, osteosynthesis plates with screw holes of 1.3 and 1.5 mm were placed on the cranial bone of New Zealand white rabbits and the bond strength of these plates was determined through tension tests. In vitro bond strengths of 19.8-26.5 MPa were obtained. Control samples, prepared without a bone bonding agent, exhibited bone bonding strengths <0.2 MPa. In vivo respective bond strengths at the cranium of the white rabbits were 2.5-4.1 MPa 2 weeks post surgery and 1.9-2.5 MPa 12 weeks after implantation. This new innovative fixation method can be envisioned for cases in which conventional fixation techniques of screws and plates are insufficient or not possible due to the bone or trauma conditions. The observed bonding strengths support implementing this technique in nonload bearing regions, such as the central midface or frontal sinus, facilitating immobilization until bone reunion is complete.
AB - This study evaluates a novel adhesive fixation technique to affix cortical bone fragments to osteosynthesis plates using common PMMA cement. This technique utilizes a new amphiphilic bone bonding agent adhering with both hydrophilic bone and hydrophobic PMMA cement. After in vitro biomechanical testing of the bonding strength with explanted bovine and rabbit calvarian bone samples, osteosynthesis plates with screw holes of 1.3 and 1.5 mm were placed on the cranial bone of New Zealand white rabbits and the bond strength of these plates was determined through tension tests. In vitro bond strengths of 19.8-26.5 MPa were obtained. Control samples, prepared without a bone bonding agent, exhibited bone bonding strengths <0.2 MPa. In vivo respective bond strengths at the cranium of the white rabbits were 2.5-4.1 MPa 2 weeks post surgery and 1.9-2.5 MPa 12 weeks after implantation. This new innovative fixation method can be envisioned for cases in which conventional fixation techniques of screws and plates are insufficient or not possible due to the bone or trauma conditions. The observed bonding strengths support implementing this technique in nonload bearing regions, such as the central midface or frontal sinus, facilitating immobilization until bone reunion is complete.
KW - Adhesiveness
KW - Animals
KW - Biomechanical Phenomena
KW - Bone Cements
KW - Dogs
KW - Facial Bones
KW - Fracture Fixation, Internal
KW - Polymethyl Methacrylate
KW - Rabbits
KW - Skull
KW - Skull Fractures
KW - Tensile Strength
KW - Tissue Adhesives
U2 - 10.1002/jbm.a.34505
DO - 10.1002/jbm.a.34505
M3 - SCORING: Journal article
C2 - 23280988
VL - 101
SP - 2058
EP - 2066
JO - J BIOMED MATER RES A
JF - J BIOMED MATER RES A
SN - 1549-3296
IS - 7
ER -
