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The Initial Slope of the Variogram, Foundation of the Trabecular Bone Score, Is Not or Is Poorly Associated With Vertebral Strength

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The Initial Slope of the Variogram, Foundation of the Trabecular Bone Score, Is Not or Is Poorly Associated With Vertebral Strength. / Maquer, Ghislain; Lu, Yongtao; Dall'Ara, Enrico; Chevalier, Yan; Krause, Matthias; Yang, Lang; Eastell, Richard; Lippuner, Kurt; Zysset, Philippe K.

In: J BONE MINER RES, Vol. 31, No. 2, 02.2016, p. 341-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Maquer, G, Lu, Y, Dall'Ara, E, Chevalier, Y, Krause, M, Yang, L, Eastell, R, Lippuner, K & Zysset, PK 2016, 'The Initial Slope of the Variogram, Foundation of the Trabecular Bone Score, Is Not or Is Poorly Associated With Vertebral Strength', J BONE MINER RES, vol. 31, no. 2, pp. 341-6. https://doi.org/10.1002/jbmr.2610

APA

Maquer, G., Lu, Y., Dall'Ara, E., Chevalier, Y., Krause, M., Yang, L., Eastell, R., Lippuner, K., & Zysset, P. K. (2016). The Initial Slope of the Variogram, Foundation of the Trabecular Bone Score, Is Not or Is Poorly Associated With Vertebral Strength. J BONE MINER RES, 31(2), 341-6. https://doi.org/10.1002/jbmr.2610

Vancouver

Maquer G, Lu Y, Dall'Ara E, Chevalier Y, Krause M, Yang L et al. The Initial Slope of the Variogram, Foundation of the Trabecular Bone Score, Is Not or Is Poorly Associated With Vertebral Strength. J BONE MINER RES. 2016 Feb;31(2):341-6. https://doi.org/10.1002/jbmr.2610

Bibtex

@article{1f69f1638ca04353a2e8b85424f0125f,
title = "The Initial Slope of the Variogram, Foundation of the Trabecular Bone Score, Is Not or Is Poorly Associated With Vertebral Strength",
abstract = "Trabecular bone score (TBS) rests on the textural analysis of dual-energy X-ray absorptiometry (DXA) to reflect the decay in trabecular structure characterizing osteoporosis. Yet, its discriminative power in fracture studies remains incomprehensible because prior biomechanical tests found no correlation with vertebral strength. To verify this result possibly owing to an unrealistic setup and to cover a wide range of loading scenarios, the data from three previous biomechanical studies using different experimental settings were used. They involved the compressive failure of 62 human lumbar vertebrae loaded 1) via intervertebral discs to mimic the in vivo situation ({"}full vertebra{"}); 2) via the classical endplate embedding ({"}vertebral body{"}); or 3) via a ball joint to induce anterior wedge failure ({"}vertebral section{"}). High-resolution peripheral quantitative computed tomography (HR-pQCT) scans acquired from prior testing were used to simulate anterior-posterior DXA from which areal bone mineral density (aBMD) and the initial slope of the variogram (ISV), the early definition of TBS, were evaluated. Finally, the relation of aBMD and ISV with failure load (F(exp)) and apparent failure stress (σexp) was assessed, and their relative contribution to a multilinear model was quantified via ANOVA. We found that, unlike aBMD, ISV did not significantly correlate with F(exp) and σexp , except for the {"}vertebral body{"} case (r(2) = 0.396, p = 0.028). Aside from the {"}vertebra section{"} setup where it explained only 6.4% of σexp (p = 0.037), it brought no significant improvement to aBMD. These results indicate that ISV, a replica of TBS, is a poor surrogate for vertebral strength no matter the testing setup, which supports the prior observations and raises a fortiori the question of the deterministic factors underlying the statistical relationship between TBS and vertebral fracture risk.",
keywords = "Absorptiometry, Photon, Aged, Aged, 80 and over, Bone Density, Humans, Intervertebral Disc, Lumbar Vertebrae, Male, Middle Aged, Models, Biological, Tomography, X-Ray Computed, Weight-Bearing, Journal Article, Research Support, Non-U.S. Gov't",
author = "Ghislain Maquer and Yongtao Lu and Enrico Dall'Ara and Yan Chevalier and Matthias Krause and Lang Yang and Richard Eastell and Kurt Lippuner and Zysset, {Philippe K}",
note = "{\textcopyright} 2015 American Society for Bone and Mineral Research.",
year = "2016",
month = feb,
doi = "10.1002/jbmr.2610",
language = "English",
volume = "31",
pages = "341--6",
journal = "J BONE MINER RES",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - The Initial Slope of the Variogram, Foundation of the Trabecular Bone Score, Is Not or Is Poorly Associated With Vertebral Strength

AU - Maquer, Ghislain

AU - Lu, Yongtao

AU - Dall'Ara, Enrico

AU - Chevalier, Yan

AU - Krause, Matthias

AU - Yang, Lang

AU - Eastell, Richard

AU - Lippuner, Kurt

AU - Zysset, Philippe K

N1 - © 2015 American Society for Bone and Mineral Research.

PY - 2016/2

Y1 - 2016/2

N2 - Trabecular bone score (TBS) rests on the textural analysis of dual-energy X-ray absorptiometry (DXA) to reflect the decay in trabecular structure characterizing osteoporosis. Yet, its discriminative power in fracture studies remains incomprehensible because prior biomechanical tests found no correlation with vertebral strength. To verify this result possibly owing to an unrealistic setup and to cover a wide range of loading scenarios, the data from three previous biomechanical studies using different experimental settings were used. They involved the compressive failure of 62 human lumbar vertebrae loaded 1) via intervertebral discs to mimic the in vivo situation ("full vertebra"); 2) via the classical endplate embedding ("vertebral body"); or 3) via a ball joint to induce anterior wedge failure ("vertebral section"). High-resolution peripheral quantitative computed tomography (HR-pQCT) scans acquired from prior testing were used to simulate anterior-posterior DXA from which areal bone mineral density (aBMD) and the initial slope of the variogram (ISV), the early definition of TBS, were evaluated. Finally, the relation of aBMD and ISV with failure load (F(exp)) and apparent failure stress (σexp) was assessed, and their relative contribution to a multilinear model was quantified via ANOVA. We found that, unlike aBMD, ISV did not significantly correlate with F(exp) and σexp , except for the "vertebral body" case (r(2) = 0.396, p = 0.028). Aside from the "vertebra section" setup where it explained only 6.4% of σexp (p = 0.037), it brought no significant improvement to aBMD. These results indicate that ISV, a replica of TBS, is a poor surrogate for vertebral strength no matter the testing setup, which supports the prior observations and raises a fortiori the question of the deterministic factors underlying the statistical relationship between TBS and vertebral fracture risk.

AB - Trabecular bone score (TBS) rests on the textural analysis of dual-energy X-ray absorptiometry (DXA) to reflect the decay in trabecular structure characterizing osteoporosis. Yet, its discriminative power in fracture studies remains incomprehensible because prior biomechanical tests found no correlation with vertebral strength. To verify this result possibly owing to an unrealistic setup and to cover a wide range of loading scenarios, the data from three previous biomechanical studies using different experimental settings were used. They involved the compressive failure of 62 human lumbar vertebrae loaded 1) via intervertebral discs to mimic the in vivo situation ("full vertebra"); 2) via the classical endplate embedding ("vertebral body"); or 3) via a ball joint to induce anterior wedge failure ("vertebral section"). High-resolution peripheral quantitative computed tomography (HR-pQCT) scans acquired from prior testing were used to simulate anterior-posterior DXA from which areal bone mineral density (aBMD) and the initial slope of the variogram (ISV), the early definition of TBS, were evaluated. Finally, the relation of aBMD and ISV with failure load (F(exp)) and apparent failure stress (σexp) was assessed, and their relative contribution to a multilinear model was quantified via ANOVA. We found that, unlike aBMD, ISV did not significantly correlate with F(exp) and σexp , except for the "vertebral body" case (r(2) = 0.396, p = 0.028). Aside from the "vertebra section" setup where it explained only 6.4% of σexp (p = 0.037), it brought no significant improvement to aBMD. These results indicate that ISV, a replica of TBS, is a poor surrogate for vertebral strength no matter the testing setup, which supports the prior observations and raises a fortiori the question of the deterministic factors underlying the statistical relationship between TBS and vertebral fracture risk.

KW - Absorptiometry, Photon

KW - Aged

KW - Aged, 80 and over

KW - Bone Density

KW - Humans

KW - Intervertebral Disc

KW - Lumbar Vertebrae

KW - Male

KW - Middle Aged

KW - Models, Biological

KW - Tomography, X-Ray Computed

KW - Weight-Bearing

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/jbmr.2610

DO - 10.1002/jbmr.2610

M3 - SCORING: Journal article

C2 - 26234619

VL - 31

SP - 341

EP - 346

JO - J BONE MINER RES

JF - J BONE MINER RES

SN - 0884-0431

IS - 2

ER -