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The influence of intraoperative resection control modalities on survival following gross total resection of glioblastoma

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The influence of intraoperative resection control modalities on survival following gross total resection of glioblastoma. / Neidert, Marian C; Hostettler, Isabel C; Burkhardt, Jan-Karl; Mohme, Malte; Held, Ulrike; Kofmehl, Reto; Eisele, Günter; Woernle, Christoph M; Regli, Luca; Bozinov, Oliver.

In: NEUROSURG REV, Vol. 39, No. 3, 07.2016, p. 401-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Neidert, MC, Hostettler, IC, Burkhardt, J-K, Mohme, M, Held, U, Kofmehl, R, Eisele, G, Woernle, CM, Regli, L & Bozinov, O 2016, 'The influence of intraoperative resection control modalities on survival following gross total resection of glioblastoma', NEUROSURG REV, vol. 39, no. 3, pp. 401-9. https://doi.org/10.1007/s10143-015-0698-z

APA

Neidert, M. C., Hostettler, I. C., Burkhardt, J-K., Mohme, M., Held, U., Kofmehl, R., Eisele, G., Woernle, C. M., Regli, L., & Bozinov, O. (2016). The influence of intraoperative resection control modalities on survival following gross total resection of glioblastoma. NEUROSURG REV, 39(3), 401-9. https://doi.org/10.1007/s10143-015-0698-z

Vancouver

Neidert MC, Hostettler IC, Burkhardt J-K, Mohme M, Held U, Kofmehl R et al. The influence of intraoperative resection control modalities on survival following gross total resection of glioblastoma. NEUROSURG REV. 2016 Jul;39(3):401-9. https://doi.org/10.1007/s10143-015-0698-z

Bibtex

@article{8c85fb43acff4d53b86fcaaf4fc15edc,
title = "The influence of intraoperative resection control modalities on survival following gross total resection of glioblastoma",
abstract = "The purpose of the present study is to analyze the impact of intraoperative resection control modalities on overall survival (OS) and progression-free survival (PFS) following gross total resection (GTR) of glioblastoma. We analyzed data of 76 glioblastoma patients (30f, mean age 57.4 ± 11.6 years) operated at our institution between 2009 and 2012. Patients were only included if GTR was achieved as judged by early postoperative high-field MRI. Intraoperative technical resection control modalities comprised intraoperative ultrasound (ioUS, n = 48), intraoperative low-field MRI (ioMRI, n = 22), and a control group without either modality (n = 11). The primary endpoint of our study was OS, and the secondary endpoint was PFS-both analyzed in Kaplan-Meier plots and Cox proportional hazards models. Median OS in all 76 glioblastoma patients after GTR was 20.4 months (95 % confidence interval (CI) 18.5-29.0)-median OS in patients where GTR was achieved using ioUS was prolonged (21.9 months) compared to those without ioUS usage (18.8 months). A multiple Cox model adjusting for age, preop Karnofsky performance status, tumor volume, and the use of 5-aminolevulinic acid showed a beneficial effect of ioUS use, and the estimated hazard ratio was 0.63 (95 % CI 0.31-1.2, p = 0.18) in favor of ioUS, however not reaching statistical significance. A similar effect was found for PFS (hazard ratio 0.59, p = 0.072). GTR of glioblastoma performed with ioUS guidance was associated with prolonged OS and PFS. IoUS should be compared to other resection control devices in larger patient cohorts.",
keywords = "Journal Article",
author = "Neidert, {Marian C} and Hostettler, {Isabel C} and Jan-Karl Burkhardt and Malte Mohme and Ulrike Held and Reto Kofmehl and G{\"u}nter Eisele and Woernle, {Christoph M} and Luca Regli and Oliver Bozinov",
year = "2016",
month = jul,
doi = "10.1007/s10143-015-0698-z",
language = "English",
volume = "39",
pages = "401--9",
journal = "NEUROSURG REV",
issn = "0344-5607",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - The influence of intraoperative resection control modalities on survival following gross total resection of glioblastoma

AU - Neidert, Marian C

AU - Hostettler, Isabel C

AU - Burkhardt, Jan-Karl

AU - Mohme, Malte

AU - Held, Ulrike

AU - Kofmehl, Reto

AU - Eisele, Günter

AU - Woernle, Christoph M

AU - Regli, Luca

AU - Bozinov, Oliver

PY - 2016/7

Y1 - 2016/7

N2 - The purpose of the present study is to analyze the impact of intraoperative resection control modalities on overall survival (OS) and progression-free survival (PFS) following gross total resection (GTR) of glioblastoma. We analyzed data of 76 glioblastoma patients (30f, mean age 57.4 ± 11.6 years) operated at our institution between 2009 and 2012. Patients were only included if GTR was achieved as judged by early postoperative high-field MRI. Intraoperative technical resection control modalities comprised intraoperative ultrasound (ioUS, n = 48), intraoperative low-field MRI (ioMRI, n = 22), and a control group without either modality (n = 11). The primary endpoint of our study was OS, and the secondary endpoint was PFS-both analyzed in Kaplan-Meier plots and Cox proportional hazards models. Median OS in all 76 glioblastoma patients after GTR was 20.4 months (95 % confidence interval (CI) 18.5-29.0)-median OS in patients where GTR was achieved using ioUS was prolonged (21.9 months) compared to those without ioUS usage (18.8 months). A multiple Cox model adjusting for age, preop Karnofsky performance status, tumor volume, and the use of 5-aminolevulinic acid showed a beneficial effect of ioUS use, and the estimated hazard ratio was 0.63 (95 % CI 0.31-1.2, p = 0.18) in favor of ioUS, however not reaching statistical significance. A similar effect was found for PFS (hazard ratio 0.59, p = 0.072). GTR of glioblastoma performed with ioUS guidance was associated with prolonged OS and PFS. IoUS should be compared to other resection control devices in larger patient cohorts.

AB - The purpose of the present study is to analyze the impact of intraoperative resection control modalities on overall survival (OS) and progression-free survival (PFS) following gross total resection (GTR) of glioblastoma. We analyzed data of 76 glioblastoma patients (30f, mean age 57.4 ± 11.6 years) operated at our institution between 2009 and 2012. Patients were only included if GTR was achieved as judged by early postoperative high-field MRI. Intraoperative technical resection control modalities comprised intraoperative ultrasound (ioUS, n = 48), intraoperative low-field MRI (ioMRI, n = 22), and a control group without either modality (n = 11). The primary endpoint of our study was OS, and the secondary endpoint was PFS-both analyzed in Kaplan-Meier plots and Cox proportional hazards models. Median OS in all 76 glioblastoma patients after GTR was 20.4 months (95 % confidence interval (CI) 18.5-29.0)-median OS in patients where GTR was achieved using ioUS was prolonged (21.9 months) compared to those without ioUS usage (18.8 months). A multiple Cox model adjusting for age, preop Karnofsky performance status, tumor volume, and the use of 5-aminolevulinic acid showed a beneficial effect of ioUS use, and the estimated hazard ratio was 0.63 (95 % CI 0.31-1.2, p = 0.18) in favor of ioUS, however not reaching statistical significance. A similar effect was found for PFS (hazard ratio 0.59, p = 0.072). GTR of glioblastoma performed with ioUS guidance was associated with prolonged OS and PFS. IoUS should be compared to other resection control devices in larger patient cohorts.

KW - Journal Article

U2 - 10.1007/s10143-015-0698-z

DO - 10.1007/s10143-015-0698-z

M3 - SCORING: Journal article

C2 - 26860420

VL - 39

SP - 401

EP - 409

JO - NEUROSURG REV

JF - NEUROSURG REV

SN - 0344-5607

IS - 3

ER -