The influence of genetic sex on sexual differentiation of diencephalic dopaminergic neurons in vitro and in vivo
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The influence of genetic sex on sexual differentiation of diencephalic dopaminergic neurons in vitro and in vivo. / Kolbinger, W; Trepel, M; Beyer, J C; Pilgrim, C; Reisert, I.
In: BRAIN RES, Vol. 544, No. 2, 29.03.1991, p. 349-52.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The influence of genetic sex on sexual differentiation of diencephalic dopaminergic neurons in vitro and in vivo
AU - Kolbinger, W
AU - Trepel, M
AU - Beyer, J C
AU - Pilgrim, C
AU - Reisert, I
PY - 1991/3/29
Y1 - 1991/3/29
N2 - Soma sizes of embryonic male and female tyrosine hydroxylase-immunoreactive neurons were measured in 3 diencephalic regions in situ and in diencephalic dissociated cell cultures. Male neurons were about 30% larger than female neurons both in vitro and in situ. Treatment of cultures with sex steroids did not affect the sex differences. It is concluded that sexual differentiation of dopaminergic neurons may be under primary genetic control.
AB - Soma sizes of embryonic male and female tyrosine hydroxylase-immunoreactive neurons were measured in 3 diencephalic regions in situ and in diencephalic dissociated cell cultures. Male neurons were about 30% larger than female neurons both in vitro and in situ. Treatment of cultures with sex steroids did not affect the sex differences. It is concluded that sexual differentiation of dopaminergic neurons may be under primary genetic control.
KW - Animals
KW - Diencephalon
KW - Dopamine
KW - Embryonic and Fetal Development
KW - In Vitro Techniques
KW - Neurons
KW - Rats
KW - Rats, Inbred Strains
KW - Sex Differentiation
KW - Tyrosine 3-Monooxygenase
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
M3 - SCORING: Journal article
C2 - 1674897
VL - 544
SP - 349
EP - 352
JO - BRAIN RES
JF - BRAIN RES
SN - 0006-8993
IS - 2
ER -