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The induction and function of the anti-inflammatory fate of TH17 cells

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The induction and function of the anti-inflammatory fate of TH17 cells. / Xu, Hao; Agalioti, Theodora; Zhao, Jun; Steglich, Babett; Wahib, Ramez; Vesely, Maria Carolina Amezcua; Bielecki, Piotr; Bailis, Will; Jackson, Ruaidhri; Perez, Daniel; Izbicki, Jakob; Licona-Limón, Paula; Kaartinen, Vesa; Geginat, Jens; Esplugues, Enric; Tolosa, Eva; Huber, Samuel; Flavell, Richard A; Gagliani, Nicola.

In: NAT COMMUN, Vol. 11, No. 1, 03.07.2020, p. 3334.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Xu, H, Agalioti, T, Zhao, J, Steglich, B, Wahib, R, Vesely, MCA, Bielecki, P, Bailis, W, Jackson, R, Perez, D, Izbicki, J, Licona-Limón, P, Kaartinen, V, Geginat, J, Esplugues, E, Tolosa, E, Huber, S, Flavell, RA & Gagliani, N 2020, 'The induction and function of the anti-inflammatory fate of TH17 cells', NAT COMMUN, vol. 11, no. 1, pp. 3334. https://doi.org/10.1038/s41467-020-17097-5

APA

Xu, H., Agalioti, T., Zhao, J., Steglich, B., Wahib, R., Vesely, M. C. A., Bielecki, P., Bailis, W., Jackson, R., Perez, D., Izbicki, J., Licona-Limón, P., Kaartinen, V., Geginat, J., Esplugues, E., Tolosa, E., Huber, S., Flavell, R. A., & Gagliani, N. (2020). The induction and function of the anti-inflammatory fate of TH17 cells. NAT COMMUN, 11(1), 3334. https://doi.org/10.1038/s41467-020-17097-5

Vancouver

Xu H, Agalioti T, Zhao J, Steglich B, Wahib R, Vesely MCA et al. The induction and function of the anti-inflammatory fate of TH17 cells. NAT COMMUN. 2020 Jul 3;11(1):3334. https://doi.org/10.1038/s41467-020-17097-5

Bibtex

@article{ce43d8dbefb44adb9f1b7ce33f9cd5f5,
title = "The induction and function of the anti-inflammatory fate of TH17 cells",
abstract = "TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cells to acquire an anti-inflammatory fate is necessary to sustain immunological tolerance, yet it impairs immune protection against S. aureus. Additionally, we find that TGF-β signalling via Smad3/Smad4 is sufficient for the expression of the anti-inflammatory cytokine, IL-10, in TH17 cells. Our data thus indicate a key function of TH17 cell plasticity in maintaining immune homeostasis, and dissect the molecular mechanisms explaining the functional flexibility of TH17 cells with regard to environmental changes.",
author = "Hao Xu and Theodora Agalioti and Jun Zhao and Babett Steglich and Ramez Wahib and Vesely, {Maria Carolina Amezcua} and Piotr Bielecki and Will Bailis and Ruaidhri Jackson and Daniel Perez and Jakob Izbicki and Paula Licona-Lim{\'o}n and Vesa Kaartinen and Jens Geginat and Enric Esplugues and Eva Tolosa and Samuel Huber and Flavell, {Richard A} and Nicola Gagliani",
year = "2020",
month = jul,
day = "3",
doi = "10.1038/s41467-020-17097-5",
language = "English",
volume = "11",
pages = "3334",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - The induction and function of the anti-inflammatory fate of TH17 cells

AU - Xu, Hao

AU - Agalioti, Theodora

AU - Zhao, Jun

AU - Steglich, Babett

AU - Wahib, Ramez

AU - Vesely, Maria Carolina Amezcua

AU - Bielecki, Piotr

AU - Bailis, Will

AU - Jackson, Ruaidhri

AU - Perez, Daniel

AU - Izbicki, Jakob

AU - Licona-Limón, Paula

AU - Kaartinen, Vesa

AU - Geginat, Jens

AU - Esplugues, Enric

AU - Tolosa, Eva

AU - Huber, Samuel

AU - Flavell, Richard A

AU - Gagliani, Nicola

PY - 2020/7/3

Y1 - 2020/7/3

N2 - TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cells to acquire an anti-inflammatory fate is necessary to sustain immunological tolerance, yet it impairs immune protection against S. aureus. Additionally, we find that TGF-β signalling via Smad3/Smad4 is sufficient for the expression of the anti-inflammatory cytokine, IL-10, in TH17 cells. Our data thus indicate a key function of TH17 cell plasticity in maintaining immune homeostasis, and dissect the molecular mechanisms explaining the functional flexibility of TH17 cells with regard to environmental changes.

AB - TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cells to acquire an anti-inflammatory fate is necessary to sustain immunological tolerance, yet it impairs immune protection against S. aureus. Additionally, we find that TGF-β signalling via Smad3/Smad4 is sufficient for the expression of the anti-inflammatory cytokine, IL-10, in TH17 cells. Our data thus indicate a key function of TH17 cell plasticity in maintaining immune homeostasis, and dissect the molecular mechanisms explaining the functional flexibility of TH17 cells with regard to environmental changes.

U2 - 10.1038/s41467-020-17097-5

DO - 10.1038/s41467-020-17097-5

M3 - SCORING: Journal article

C2 - 32620760

VL - 11

SP - 3334

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -