The importance of Ca2+ microdomains for the adaptive immune response

Björn-Philipp Diercks

doi:10.1016/j.bbamcr.2024.119710

The importance of Ca2+ microdomains for the adaptive immune response

Standard

The importance of Ca2+ microdomains for the adaptive immune response. / Diercks, Björn-Philipp.

In: BBA-MOL CELL RES, Vol. 1871, No. 5, 06.2024, p. 119710.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Diercks, B-P 2024, 'The importance of Ca2+ microdomains for the adaptive immune response', BBA-MOL CELL RES, vol. 1871, no. 5, pp. 119710. https://doi.org/10.1016/j.bbamcr.2024.119710

APA

Diercks, B-P. (2024). The importance of Ca2+ microdomains for the adaptive immune response. BBA-MOL CELL RES, 1871(5), 119710. https://doi.org/10.1016/j.bbamcr.2024.119710

Vancouver

Diercks B-P. The importance of Ca2+ microdomains for the adaptive immune response. BBA-MOL CELL RES. 2024 Jun;1871(5):119710. https://doi.org/10.1016/j.bbamcr.2024.119710

Bibtex

@article{4bfdf4e25b1446c2ac85bafbc8675cc5,

title = "The importance of Ca2+ microdomains for the adaptive immune response",

abstract = "Calcium signaling stands out as the most widespread and universally used signaling system and is of utmost importance for immunity. Controlled elevations in cytosolic and organellar Ca2+ concentrations in T cells control complex and essential effector functions including proliferation, differentiation, cytokine secretion, and cytotoxicity, among others. Additionally, disruptions in Ca2+ regulation in T cells contribute to diverse autoimmune, inflammatory, and immunodeficiency conditions. Among the initial intracellular signals, which occurring even before T cell receptor (TCR) stimulation are highly localized, spatially and temporally restricted so-called Ca2+ microdomains, caused by adhesion to extracellular matrix proteins (ECM proteins). The Ca2+ microdomains present both before and within the initial seconds following TCR stimulation are likely to play a crucial role in fine-tuning the downstream activity of T cell activation and thus, shaping an adaptive immune response. In this review, the emphasis is on the recent advances of adhesion-dependent Ca2+ microdomains (ADCM) in the absence of TCR stimulation, initial Ca2+ microdomains evoked by TCR stimulation (TDCM), the downstream signaling processes as well as possible therapeutic targets for interventions.",

author = "Bj{\"o}rn-Philipp Diercks",

note = "Copyright {\textcopyright} 2024. Published by Elsevier B.V.",

year = "2024",

month = jun,

doi = "10.1016/j.bbamcr.2024.119710",

language = "English",

volume = "1871",

pages = "119710",

journal = "BBA-MOL CELL RES",

issn = "0167-4889",

publisher = "Elsevier",

number = "5",

}

RIS

TY - JOUR

T1 - The importance of Ca2+ microdomains for the adaptive immune response

AU - Diercks, Björn-Philipp

PY - 2024/6

Y1 - 2024/6

N2 - Calcium signaling stands out as the most widespread and universally used signaling system and is of utmost importance for immunity. Controlled elevations in cytosolic and organellar Ca2+ concentrations in T cells control complex and essential effector functions including proliferation, differentiation, cytokine secretion, and cytotoxicity, among others. Additionally, disruptions in Ca2+ regulation in T cells contribute to diverse autoimmune, inflammatory, and immunodeficiency conditions. Among the initial intracellular signals, which occurring even before T cell receptor (TCR) stimulation are highly localized, spatially and temporally restricted so-called Ca2+ microdomains, caused by adhesion to extracellular matrix proteins (ECM proteins). The Ca2+ microdomains present both before and within the initial seconds following TCR stimulation are likely to play a crucial role in fine-tuning the downstream activity of T cell activation and thus, shaping an adaptive immune response. In this review, the emphasis is on the recent advances of adhesion-dependent Ca2+ microdomains (ADCM) in the absence of TCR stimulation, initial Ca2+ microdomains evoked by TCR stimulation (TDCM), the downstream signaling processes as well as possible therapeutic targets for interventions.

AB - Calcium signaling stands out as the most widespread and universally used signaling system and is of utmost importance for immunity. Controlled elevations in cytosolic and organellar Ca2+ concentrations in T cells control complex and essential effector functions including proliferation, differentiation, cytokine secretion, and cytotoxicity, among others. Additionally, disruptions in Ca2+ regulation in T cells contribute to diverse autoimmune, inflammatory, and immunodeficiency conditions. Among the initial intracellular signals, which occurring even before T cell receptor (TCR) stimulation are highly localized, spatially and temporally restricted so-called Ca2+ microdomains, caused by adhesion to extracellular matrix proteins (ECM proteins). The Ca2+ microdomains present both before and within the initial seconds following TCR stimulation are likely to play a crucial role in fine-tuning the downstream activity of T cell activation and thus, shaping an adaptive immune response. In this review, the emphasis is on the recent advances of adhesion-dependent Ca2+ microdomains (ADCM) in the absence of TCR stimulation, initial Ca2+ microdomains evoked by TCR stimulation (TDCM), the downstream signaling processes as well as possible therapeutic targets for interventions.

U2 - 10.1016/j.bbamcr.2024.119710

DO - 10.1016/j.bbamcr.2024.119710

M3 - SCORING: Review article

C2 - 38522726

VL - 1871

SP - 119710

JO - BBA-MOL CELL RES

JF - BBA-MOL CELL RES

SN - 0167-4889

IS - 5

ER -