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The impact of treatment modality on survival in patients with clinical node-positive bladder cancer: results from a multicenter collaboration

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The impact of treatment modality on survival in patients with clinical node-positive bladder cancer: results from a multicenter collaboration. / Afferi, Luca; Zamboni, Stefania; Karnes, R Jeffrey; Roghmann, Florian; Sargos, Paul; Montorsi, Francesco; Briganti, Alberto; Gallina, Andrea; Mattei, Agostino; Schulz, Gerald Bastian; Hendricksen, Kees; Voskuilen, Charlotte S; Rink, Michael; Poyet, Cedric; De Cobelli, Ottavio; di Trapani, Ettore; Simeone, Claudio; Soligo, Matteo; Simone, Giuseppe; Tuderti, Gabriele; Alvarez-Maestro, Mario; Martínez-Piñeiro, Luis; Aziz, Atiqullah; Shariat, Shahrokh F; Abufaraj, Mohammad; Xylinas, Evanguelos; Moschini, Marco; European Association of Urology – Young Academic Urologists (EAU-YAU), Urothelial Carcinoma Working Group.

In: WORLD J UROL, Vol. 39, No. 2, 02.2021, p. 443-451.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Afferi, L, Zamboni, S, Karnes, RJ, Roghmann, F, Sargos, P, Montorsi, F, Briganti, A, Gallina, A, Mattei, A, Schulz, GB, Hendricksen, K, Voskuilen, CS, Rink, M, Poyet, C, De Cobelli, O, di Trapani, E, Simeone, C, Soligo, M, Simone, G, Tuderti, G, Alvarez-Maestro, M, Martínez-Piñeiro, L, Aziz, A, Shariat, SF, Abufaraj, M, Xylinas, E, Moschini, M & European Association of Urology – Young Academic Urologists (EAU-YAU), Urothelial Carcinoma Working Group 2021, 'The impact of treatment modality on survival in patients with clinical node-positive bladder cancer: results from a multicenter collaboration', WORLD J UROL, vol. 39, no. 2, pp. 443-451. https://doi.org/10.1007/s00345-020-03205-z

APA

Afferi, L., Zamboni, S., Karnes, R. J., Roghmann, F., Sargos, P., Montorsi, F., Briganti, A., Gallina, A., Mattei, A., Schulz, G. B., Hendricksen, K., Voskuilen, C. S., Rink, M., Poyet, C., De Cobelli, O., di Trapani, E., Simeone, C., Soligo, M., Simone, G., ... European Association of Urology – Young Academic Urologists (EAU-YAU), Urothelial Carcinoma Working Group (2021). The impact of treatment modality on survival in patients with clinical node-positive bladder cancer: results from a multicenter collaboration. WORLD J UROL, 39(2), 443-451. https://doi.org/10.1007/s00345-020-03205-z

Vancouver

Afferi L, Zamboni S, Karnes RJ, Roghmann F, Sargos P, Montorsi F et al. The impact of treatment modality on survival in patients with clinical node-positive bladder cancer: results from a multicenter collaboration. WORLD J UROL. 2021 Feb;39(2):443-451. https://doi.org/10.1007/s00345-020-03205-z

Bibtex

@article{ae4bd17ff136427eb19bf03548728e20,
title = "The impact of treatment modality on survival in patients with clinical node-positive bladder cancer: results from a multicenter collaboration",
abstract = "PURPOSE: To assess the impact of perioperative chemotherapy on survival in cN+ BCa patients and analyze it according to the pN status.METHODS: A retrospective analysis was conducted on 639 BCa patients with cTanyN1-3M0 BCa treated with radical cystectomy (RC) and bilateral lymph node dissection (LND) with or without perioperative chemotherapy in ten tertiary referral centers from 1990 to 2017. Selected cN+ patients received induction chemotherapy (IC), whereas adjuvant chemotherapy (ACT) was delivered to selected pN+ patients. Univariable and multivariable Cox regression analyses were used to predict overall mortality (OM) after surgery, adjusting for clinicopathological confounders. Kaplan-Meier analyses assessed OM according to the treatment modality.RESULTS: Overall, 356 (56%) patients were treated with surgery alone, 155 (24%) with IC followed by surgery, and 128 (20%) with ACT following surgery. Over a median follow-up of 25 months, 316 deaths were recorded. At univariable analysis, patients treated with IC and surgery had lower OM both considering cN+ [hazard ratio (HR) 0.65, 95% confidence interval (CI) 0.49-0.87, p = 0.004] and cN+pN- patients (HR 0.61, 95% CI 0.37-0.99, p = 0.05) compared to those treated with surgery alone. cN+pN+ patients treated with ACT experienced lower OM compared to those treated with IC or surgery alone at multivariable analysis (HR 0.40, 95% CI 0.22-0.74, p = 0.003).CONCLUSION: Patients with cTany cN+ cM0 BCa benefit more in terms of OS when treated with IC followed by RC + LND compared to RC + LND alone, regardless of LNMs at final histopathology examination. More data are needed to assess the role of ACT in the management of cN+ patients.",
author = "Luca Afferi and Stefania Zamboni and Karnes, {R Jeffrey} and Florian Roghmann and Paul Sargos and Francesco Montorsi and Alberto Briganti and Andrea Gallina and Agostino Mattei and Schulz, {Gerald Bastian} and Kees Hendricksen and Voskuilen, {Charlotte S} and Michael Rink and Cedric Poyet and {De Cobelli}, Ottavio and {di Trapani}, Ettore and Claudio Simeone and Matteo Soligo and Giuseppe Simone and Gabriele Tuderti and Mario Alvarez-Maestro and Luis Mart{\'i}nez-Pi{\~n}eiro and Atiqullah Aziz and Shariat, {Shahrokh F} and Mohammad Abufaraj and Evanguelos Xylinas and Marco Moschini and {European Association of Urology – Young Academic Urologists (EAU-YAU), Urothelial Carcinoma Working Group}",
year = "2021",
month = feb,
doi = "10.1007/s00345-020-03205-z",
language = "English",
volume = "39",
pages = "443--451",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - The impact of treatment modality on survival in patients with clinical node-positive bladder cancer: results from a multicenter collaboration

AU - Afferi, Luca

AU - Zamboni, Stefania

AU - Karnes, R Jeffrey

AU - Roghmann, Florian

AU - Sargos, Paul

AU - Montorsi, Francesco

AU - Briganti, Alberto

AU - Gallina, Andrea

AU - Mattei, Agostino

AU - Schulz, Gerald Bastian

AU - Hendricksen, Kees

AU - Voskuilen, Charlotte S

AU - Rink, Michael

AU - Poyet, Cedric

AU - De Cobelli, Ottavio

AU - di Trapani, Ettore

AU - Simeone, Claudio

AU - Soligo, Matteo

AU - Simone, Giuseppe

AU - Tuderti, Gabriele

AU - Alvarez-Maestro, Mario

AU - Martínez-Piñeiro, Luis

AU - Aziz, Atiqullah

AU - Shariat, Shahrokh F

AU - Abufaraj, Mohammad

AU - Xylinas, Evanguelos

AU - Moschini, Marco

AU - European Association of Urology – Young Academic Urologists (EAU-YAU), Urothelial Carcinoma Working Group

PY - 2021/2

Y1 - 2021/2

N2 - PURPOSE: To assess the impact of perioperative chemotherapy on survival in cN+ BCa patients and analyze it according to the pN status.METHODS: A retrospective analysis was conducted on 639 BCa patients with cTanyN1-3M0 BCa treated with radical cystectomy (RC) and bilateral lymph node dissection (LND) with or without perioperative chemotherapy in ten tertiary referral centers from 1990 to 2017. Selected cN+ patients received induction chemotherapy (IC), whereas adjuvant chemotherapy (ACT) was delivered to selected pN+ patients. Univariable and multivariable Cox regression analyses were used to predict overall mortality (OM) after surgery, adjusting for clinicopathological confounders. Kaplan-Meier analyses assessed OM according to the treatment modality.RESULTS: Overall, 356 (56%) patients were treated with surgery alone, 155 (24%) with IC followed by surgery, and 128 (20%) with ACT following surgery. Over a median follow-up of 25 months, 316 deaths were recorded. At univariable analysis, patients treated with IC and surgery had lower OM both considering cN+ [hazard ratio (HR) 0.65, 95% confidence interval (CI) 0.49-0.87, p = 0.004] and cN+pN- patients (HR 0.61, 95% CI 0.37-0.99, p = 0.05) compared to those treated with surgery alone. cN+pN+ patients treated with ACT experienced lower OM compared to those treated with IC or surgery alone at multivariable analysis (HR 0.40, 95% CI 0.22-0.74, p = 0.003).CONCLUSION: Patients with cTany cN+ cM0 BCa benefit more in terms of OS when treated with IC followed by RC + LND compared to RC + LND alone, regardless of LNMs at final histopathology examination. More data are needed to assess the role of ACT in the management of cN+ patients.

AB - PURPOSE: To assess the impact of perioperative chemotherapy on survival in cN+ BCa patients and analyze it according to the pN status.METHODS: A retrospective analysis was conducted on 639 BCa patients with cTanyN1-3M0 BCa treated with radical cystectomy (RC) and bilateral lymph node dissection (LND) with or without perioperative chemotherapy in ten tertiary referral centers from 1990 to 2017. Selected cN+ patients received induction chemotherapy (IC), whereas adjuvant chemotherapy (ACT) was delivered to selected pN+ patients. Univariable and multivariable Cox regression analyses were used to predict overall mortality (OM) after surgery, adjusting for clinicopathological confounders. Kaplan-Meier analyses assessed OM according to the treatment modality.RESULTS: Overall, 356 (56%) patients were treated with surgery alone, 155 (24%) with IC followed by surgery, and 128 (20%) with ACT following surgery. Over a median follow-up of 25 months, 316 deaths were recorded. At univariable analysis, patients treated with IC and surgery had lower OM both considering cN+ [hazard ratio (HR) 0.65, 95% confidence interval (CI) 0.49-0.87, p = 0.004] and cN+pN- patients (HR 0.61, 95% CI 0.37-0.99, p = 0.05) compared to those treated with surgery alone. cN+pN+ patients treated with ACT experienced lower OM compared to those treated with IC or surgery alone at multivariable analysis (HR 0.40, 95% CI 0.22-0.74, p = 0.003).CONCLUSION: Patients with cTany cN+ cM0 BCa benefit more in terms of OS when treated with IC followed by RC + LND compared to RC + LND alone, regardless of LNMs at final histopathology examination. More data are needed to assess the role of ACT in the management of cN+ patients.

U2 - 10.1007/s00345-020-03205-z

DO - 10.1007/s00345-020-03205-z

M3 - SCORING: Journal article

C2 - 32356226

VL - 39

SP - 443

EP - 451

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 2

ER -