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The impact of emotional dysregulation and comorbid depressive symptoms on clinical features, brain arousal, and treatment response in adults with ADHD

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The impact of emotional dysregulation and comorbid depressive symptoms on clinical features, brain arousal, and treatment response in adults with ADHD. / Huang, Jue; Mauche, Nicole; Ahlers, Eike; Bogatsch, Holger; Böhme, Pierre; Ethofer, Thomas; Fallgatter, Andreas J; Gallinat, Jürgen; Hegerl, Ulrich; Heuser, Isabella; Hoffmann, Knut; Kittel-Schneider, Sarah; Reif, Andreas; Schöttle, Daniel; Unterecker, Stefan; Strauß, Maria.

In: FRONT PSYCHIATRY, Vol. 14, 2023, p. 1294314.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Huang, J, Mauche, N, Ahlers, E, Bogatsch, H, Böhme, P, Ethofer, T, Fallgatter, AJ, Gallinat, J, Hegerl, U, Heuser, I, Hoffmann, K, Kittel-Schneider, S, Reif, A, Schöttle, D, Unterecker, S & Strauß, M 2023, 'The impact of emotional dysregulation and comorbid depressive symptoms on clinical features, brain arousal, and treatment response in adults with ADHD', FRONT PSYCHIATRY, vol. 14, pp. 1294314. https://doi.org/10.3389/fpsyt.2023.1294314

APA

Huang, J., Mauche, N., Ahlers, E., Bogatsch, H., Böhme, P., Ethofer, T., Fallgatter, A. J., Gallinat, J., Hegerl, U., Heuser, I., Hoffmann, K., Kittel-Schneider, S., Reif, A., Schöttle, D., Unterecker, S., & Strauß, M. (2023). The impact of emotional dysregulation and comorbid depressive symptoms on clinical features, brain arousal, and treatment response in adults with ADHD. FRONT PSYCHIATRY, 14, 1294314. https://doi.org/10.3389/fpsyt.2023.1294314

Vancouver

Huang J, Mauche N, Ahlers E, Bogatsch H, Böhme P, Ethofer T et al. The impact of emotional dysregulation and comorbid depressive symptoms on clinical features, brain arousal, and treatment response in adults with ADHD. FRONT PSYCHIATRY. 2023;14:1294314. https://doi.org/10.3389/fpsyt.2023.1294314

Bibtex

@article{b012e8c05e9c4889bc8a4775e6de65f3,
title = "The impact of emotional dysregulation and comorbid depressive symptoms on clinical features, brain arousal, and treatment response in adults with ADHD",
abstract = "INTRODUCTION: The role of emotional dysregulation (ED) in attention-deficit/hyperactivity disorder (ADHD) has become an important issue. This study, in which we analyzed data from a predictive pharmaco-EEG-trial, aimed to examine whether symptoms of ED in adult ADHD affect ADHD symptom severity, brain arousal regulation as measured by resting EEG, and the response to stimulant medication.METHODS: ED is defined as having a sex- and age-corrected T-score of >70 on the emotional lability subscale of the German version of Conners' Adult ADHD Rating Scale. A total of 115 participants were included in the study, 56 of whom had ED. Participants with ED were more impaired in terms of the severity of core ADHD symptoms, especially inattentive symptoms, comorbid depressive symptoms, interpersonal relationships, and quality of life. In addition, participants with ED were more likely to report a total score above 13 on the Beck Depression Inventory-II, which was considered to be the cutoff for mild depression.RESULTS: No differences were found between the ED and non-ED groups in response to stimulant medication or in brain arousal regulation. In addition, there was no significant effect of ED with comorbid depressive symptoms on treatment response. There was a trend for subgroups that showed a change in brain arousal regulation associated with symptom improvement.DISCUSSION: Our findings may support the assumption that ED may be an important feature of ADHD. The use of EEG-based brain arousal regulation as a diagnostic and predictive tool in ADHD in the presence of ED and comorbid depressive symptoms should be further investigated.",
author = "Jue Huang and Nicole Mauche and Eike Ahlers and Holger Bogatsch and Pierre B{\"o}hme and Thomas Ethofer and Fallgatter, {Andreas J} and J{\"u}rgen Gallinat and Ulrich Hegerl and Isabella Heuser and Knut Hoffmann and Sarah Kittel-Schneider and Andreas Reif and Daniel Sch{\"o}ttle and Stefan Unterecker and Maria Strau{\ss}",
note = "Copyright {\textcopyright} 2024 Huang, Mauche, Ahlers, Bogatsch, B{\"o}hme, Ethofer, Fallgatter, Gallinat, Hegerl, Heuser, Hoffmann, Kittel-Schneider, Reif, Sch{\"o}ttle, Unterecker and Strau{\ss}.",
year = "2023",
doi = "10.3389/fpsyt.2023.1294314",
language = "English",
volume = "14",
pages = "1294314",
journal = "FRONT PSYCHIATRY",
issn = "1664-0640",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - The impact of emotional dysregulation and comorbid depressive symptoms on clinical features, brain arousal, and treatment response in adults with ADHD

AU - Huang, Jue

AU - Mauche, Nicole

AU - Ahlers, Eike

AU - Bogatsch, Holger

AU - Böhme, Pierre

AU - Ethofer, Thomas

AU - Fallgatter, Andreas J

AU - Gallinat, Jürgen

AU - Hegerl, Ulrich

AU - Heuser, Isabella

AU - Hoffmann, Knut

AU - Kittel-Schneider, Sarah

AU - Reif, Andreas

AU - Schöttle, Daniel

AU - Unterecker, Stefan

AU - Strauß, Maria

N1 - Copyright © 2024 Huang, Mauche, Ahlers, Bogatsch, Böhme, Ethofer, Fallgatter, Gallinat, Hegerl, Heuser, Hoffmann, Kittel-Schneider, Reif, Schöttle, Unterecker and Strauß.

PY - 2023

Y1 - 2023

N2 - INTRODUCTION: The role of emotional dysregulation (ED) in attention-deficit/hyperactivity disorder (ADHD) has become an important issue. This study, in which we analyzed data from a predictive pharmaco-EEG-trial, aimed to examine whether symptoms of ED in adult ADHD affect ADHD symptom severity, brain arousal regulation as measured by resting EEG, and the response to stimulant medication.METHODS: ED is defined as having a sex- and age-corrected T-score of >70 on the emotional lability subscale of the German version of Conners' Adult ADHD Rating Scale. A total of 115 participants were included in the study, 56 of whom had ED. Participants with ED were more impaired in terms of the severity of core ADHD symptoms, especially inattentive symptoms, comorbid depressive symptoms, interpersonal relationships, and quality of life. In addition, participants with ED were more likely to report a total score above 13 on the Beck Depression Inventory-II, which was considered to be the cutoff for mild depression.RESULTS: No differences were found between the ED and non-ED groups in response to stimulant medication or in brain arousal regulation. In addition, there was no significant effect of ED with comorbid depressive symptoms on treatment response. There was a trend for subgroups that showed a change in brain arousal regulation associated with symptom improvement.DISCUSSION: Our findings may support the assumption that ED may be an important feature of ADHD. The use of EEG-based brain arousal regulation as a diagnostic and predictive tool in ADHD in the presence of ED and comorbid depressive symptoms should be further investigated.

AB - INTRODUCTION: The role of emotional dysregulation (ED) in attention-deficit/hyperactivity disorder (ADHD) has become an important issue. This study, in which we analyzed data from a predictive pharmaco-EEG-trial, aimed to examine whether symptoms of ED in adult ADHD affect ADHD symptom severity, brain arousal regulation as measured by resting EEG, and the response to stimulant medication.METHODS: ED is defined as having a sex- and age-corrected T-score of >70 on the emotional lability subscale of the German version of Conners' Adult ADHD Rating Scale. A total of 115 participants were included in the study, 56 of whom had ED. Participants with ED were more impaired in terms of the severity of core ADHD symptoms, especially inattentive symptoms, comorbid depressive symptoms, interpersonal relationships, and quality of life. In addition, participants with ED were more likely to report a total score above 13 on the Beck Depression Inventory-II, which was considered to be the cutoff for mild depression.RESULTS: No differences were found between the ED and non-ED groups in response to stimulant medication or in brain arousal regulation. In addition, there was no significant effect of ED with comorbid depressive symptoms on treatment response. There was a trend for subgroups that showed a change in brain arousal regulation associated with symptom improvement.DISCUSSION: Our findings may support the assumption that ED may be an important feature of ADHD. The use of EEG-based brain arousal regulation as a diagnostic and predictive tool in ADHD in the presence of ED and comorbid depressive symptoms should be further investigated.

U2 - 10.3389/fpsyt.2023.1294314

DO - 10.3389/fpsyt.2023.1294314

M3 - SCORING: Journal article

C2 - 38250266

VL - 14

SP - 1294314

JO - FRONT PSYCHIATRY

JF - FRONT PSYCHIATRY

SN - 1664-0640

ER -