The Impact of Antimicrobial Therapy Duration in the Treatment of Prosthetic Joint Infections Depending on Surgical Strategies:A Systematic Review and Meta-analysis
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The Impact of Antimicrobial Therapy Duration in the Treatment of Prosthetic Joint Infections Depending on Surgical Strategies:A Systematic Review and Meta-analysis. / Olearo, Flaminia; Zanichelli, Veronica; Exarchakou, Aimilia; Both, Anna; Uςkay, Ilker; Aepfelbacher, Martin; Rohde, Holger.
In: OPEN FORUM INFECT DI, Vol. 10, No. 5, ofad246, 05.2023.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - The Impact of Antimicrobial Therapy Duration in the Treatment of Prosthetic Joint Infections Depending on Surgical Strategies:A Systematic Review and Meta-analysis
AU - Olearo, Flaminia
AU - Zanichelli, Veronica
AU - Exarchakou, Aimilia
AU - Both, Anna
AU - Uςkay, Ilker
AU - Aepfelbacher, Martin
AU - Rohde, Holger
N1 - © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2023/5
Y1 - 2023/5
N2 - The aim of this systematic review was to address the question if short antibiotic treatment (SAT; at least 4 but <12 weeks) versus long antibiotic treatment (LAT) affects outcomes in prosthetic joint infections (PJIs). Database research (Medline, Embase, Web of Science, Scopus, Cochrane) retrieved 3740 articles, of which 10 studies were included in the analysis. Compared to LAT, 11% lower odds of treatment failure in the SAT group were found, although the difference was not statistically significant (pooled odds ratio, 0.89 [95% confidence interval, .53-1.50]). No difference in treatment failure was found between SAT and LAT once stratified by type of surgery, studies conducted in the United States versus Europe, study design, and follow-up. There is still no conclusive evidence that antibiotic treatment of PJIs for 12 weeks or longer is associated with better outcomes, irrespective of the type of surgical procedure. Most recent, high-quality studies tend to favor longer antibiotic courses, making them preferable in most situations.
AB - The aim of this systematic review was to address the question if short antibiotic treatment (SAT; at least 4 but <12 weeks) versus long antibiotic treatment (LAT) affects outcomes in prosthetic joint infections (PJIs). Database research (Medline, Embase, Web of Science, Scopus, Cochrane) retrieved 3740 articles, of which 10 studies were included in the analysis. Compared to LAT, 11% lower odds of treatment failure in the SAT group were found, although the difference was not statistically significant (pooled odds ratio, 0.89 [95% confidence interval, .53-1.50]). No difference in treatment failure was found between SAT and LAT once stratified by type of surgery, studies conducted in the United States versus Europe, study design, and follow-up. There is still no conclusive evidence that antibiotic treatment of PJIs for 12 weeks or longer is associated with better outcomes, irrespective of the type of surgical procedure. Most recent, high-quality studies tend to favor longer antibiotic courses, making them preferable in most situations.
U2 - 10.1093/ofid/ofad246
DO - 10.1093/ofid/ofad246
M3 - SCORING: Review article
C2 - 37265666
VL - 10
JO - OPEN FORUM INFECT DI
JF - OPEN FORUM INFECT DI
SN - 2328-8957
IS - 5
M1 - ofad246
ER -
