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The impact of aluminium in acid-suppressing drugs on the immune response of BALB/c mice

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The impact of aluminium in acid-suppressing drugs on the immune response of BALB/c mice. / Brunner, R; Wallmann, J; Szalai, K; Karagiannis, P; Kopp, T; Scheiner, O; Jensen-Jarolim, E; Pali-Schöll, I.

In: CLIN EXP ALLERGY, Vol. 37, No. 10, 10.2007, p. 1566-73.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Brunner, R, Wallmann, J, Szalai, K, Karagiannis, P, Kopp, T, Scheiner, O, Jensen-Jarolim, E & Pali-Schöll, I 2007, 'The impact of aluminium in acid-suppressing drugs on the immune response of BALB/c mice', CLIN EXP ALLERGY, vol. 37, no. 10, pp. 1566-73. https://doi.org/10.1111/j.1365-2222.2007.02813.x

APA

Brunner, R., Wallmann, J., Szalai, K., Karagiannis, P., Kopp, T., Scheiner, O., Jensen-Jarolim, E., & Pali-Schöll, I. (2007). The impact of aluminium in acid-suppressing drugs on the immune response of BALB/c mice. CLIN EXP ALLERGY, 37(10), 1566-73. https://doi.org/10.1111/j.1365-2222.2007.02813.x

Vancouver

Brunner R, Wallmann J, Szalai K, Karagiannis P, Kopp T, Scheiner O et al. The impact of aluminium in acid-suppressing drugs on the immune response of BALB/c mice. CLIN EXP ALLERGY. 2007 Oct;37(10):1566-73. https://doi.org/10.1111/j.1365-2222.2007.02813.x

Bibtex

@article{09d414db0e7d4165a2953643f199a175,
title = "The impact of aluminium in acid-suppressing drugs on the immune response of BALB/c mice",
abstract = "BACKGROUND: Recently we have shown that anti-acid drugs lead to an enhanced risk of food allergy. This may be due to hindered peptic digestion, caused by an elevation of the gastric pH. Additionally, it is known that aluminium-linked antigens lead to an increased probability of sensitization.OBJECTIVE: Our aim in this study was to show whether sucralfate promotes sensitization not only by preventing peptic digestion but also by acting as a T-helper type 2 (Th2) adjuvant.METHODS: To avoid the effect of sucralfate on the gastric pH and to show only the adjuvant effect, BALB/c mice were immunized on the parenteral route with codfish extract plus sucralfate, and control groups with aluminium hydroxide (alum) (Th2 adjuvant) or monophosphoryl lipid A (MPL) (Th1 adjuvant). Antigen-specific antibodies and cytokine levels were determined. The in vivo effect was investigated by intradermal skin tests.RESULTS: Codfish-specific high IgG1 and IgE antibody levels as well as elevated IL-4 and IL-5 levels in alum- and MPL-treated mice, but more importantly also in sucralfate-treated mice, indicated a Th2 shift. Positive skin tests confirmed this Th2 response.CONCLUSIONS: Our data show that parenterally applied sucralfate is able to induce a Th2 response probably due to the aluminium content. This indicates that orally applied sucralfate may lead to an enhanced risk of food allergy not only by inhibiting peptic digestion but also by acting as a Th2 adjuvant.",
keywords = "Aluminum/administration & dosage, Animals, Antacids/administration & dosage, Anti-Ulcer Agents/administration & dosage, Female, Fish Products, Food Hypersensitivity/immunology, Granuloma/immunology, Hydrogen-Ion Concentration, Immunity/drug effects, Interleukin-4/metabolism, Interleukin-5/metabolism, Mice, Mice, Inbred BALB C, Skin Diseases/immunology, Skin Tests, Spleen/immunology, Sucralfate/administration & dosage, Th2 Cells/drug effects",
author = "R Brunner and J Wallmann and K Szalai and P Karagiannis and T Kopp and O Scheiner and E Jensen-Jarolim and I Pali-Sch{\"o}ll",
year = "2007",
month = oct,
doi = "10.1111/j.1365-2222.2007.02813.x",
language = "English",
volume = "37",
pages = "1566--73",
journal = "CLIN EXP ALLERGY",
issn = "0954-7894",
publisher = "Wiley-Blackwell",
number = "10",

}

RIS

TY - JOUR

T1 - The impact of aluminium in acid-suppressing drugs on the immune response of BALB/c mice

AU - Brunner, R

AU - Wallmann, J

AU - Szalai, K

AU - Karagiannis, P

AU - Kopp, T

AU - Scheiner, O

AU - Jensen-Jarolim, E

AU - Pali-Schöll, I

PY - 2007/10

Y1 - 2007/10

N2 - BACKGROUND: Recently we have shown that anti-acid drugs lead to an enhanced risk of food allergy. This may be due to hindered peptic digestion, caused by an elevation of the gastric pH. Additionally, it is known that aluminium-linked antigens lead to an increased probability of sensitization.OBJECTIVE: Our aim in this study was to show whether sucralfate promotes sensitization not only by preventing peptic digestion but also by acting as a T-helper type 2 (Th2) adjuvant.METHODS: To avoid the effect of sucralfate on the gastric pH and to show only the adjuvant effect, BALB/c mice were immunized on the parenteral route with codfish extract plus sucralfate, and control groups with aluminium hydroxide (alum) (Th2 adjuvant) or monophosphoryl lipid A (MPL) (Th1 adjuvant). Antigen-specific antibodies and cytokine levels were determined. The in vivo effect was investigated by intradermal skin tests.RESULTS: Codfish-specific high IgG1 and IgE antibody levels as well as elevated IL-4 and IL-5 levels in alum- and MPL-treated mice, but more importantly also in sucralfate-treated mice, indicated a Th2 shift. Positive skin tests confirmed this Th2 response.CONCLUSIONS: Our data show that parenterally applied sucralfate is able to induce a Th2 response probably due to the aluminium content. This indicates that orally applied sucralfate may lead to an enhanced risk of food allergy not only by inhibiting peptic digestion but also by acting as a Th2 adjuvant.

AB - BACKGROUND: Recently we have shown that anti-acid drugs lead to an enhanced risk of food allergy. This may be due to hindered peptic digestion, caused by an elevation of the gastric pH. Additionally, it is known that aluminium-linked antigens lead to an increased probability of sensitization.OBJECTIVE: Our aim in this study was to show whether sucralfate promotes sensitization not only by preventing peptic digestion but also by acting as a T-helper type 2 (Th2) adjuvant.METHODS: To avoid the effect of sucralfate on the gastric pH and to show only the adjuvant effect, BALB/c mice were immunized on the parenteral route with codfish extract plus sucralfate, and control groups with aluminium hydroxide (alum) (Th2 adjuvant) or monophosphoryl lipid A (MPL) (Th1 adjuvant). Antigen-specific antibodies and cytokine levels were determined. The in vivo effect was investigated by intradermal skin tests.RESULTS: Codfish-specific high IgG1 and IgE antibody levels as well as elevated IL-4 and IL-5 levels in alum- and MPL-treated mice, but more importantly also in sucralfate-treated mice, indicated a Th2 shift. Positive skin tests confirmed this Th2 response.CONCLUSIONS: Our data show that parenterally applied sucralfate is able to induce a Th2 response probably due to the aluminium content. This indicates that orally applied sucralfate may lead to an enhanced risk of food allergy not only by inhibiting peptic digestion but also by acting as a Th2 adjuvant.

KW - Aluminum/administration & dosage

KW - Animals

KW - Antacids/administration & dosage

KW - Anti-Ulcer Agents/administration & dosage

KW - Female

KW - Fish Products

KW - Food Hypersensitivity/immunology

KW - Granuloma/immunology

KW - Hydrogen-Ion Concentration

KW - Immunity/drug effects

KW - Interleukin-4/metabolism

KW - Interleukin-5/metabolism

KW - Mice

KW - Mice, Inbred BALB C

KW - Skin Diseases/immunology

KW - Skin Tests

KW - Spleen/immunology

KW - Sucralfate/administration & dosage

KW - Th2 Cells/drug effects

U2 - 10.1111/j.1365-2222.2007.02813.x

DO - 10.1111/j.1365-2222.2007.02813.x

M3 - SCORING: Journal article

C2 - 17850381

VL - 37

SP - 1566

EP - 1573

JO - CLIN EXP ALLERGY

JF - CLIN EXP ALLERGY

SN - 0954-7894

IS - 10

ER -