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The immune system and kidney disease: basic concepts and clinical implications

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The immune system and kidney disease: basic concepts and clinical implications. / Kurts, Christian; Panzer, Ulf; Anders, Hans-Joachim; Rees, Andrew J.

In: NAT REV IMMUNOL, Vol. 13, No. 10, 01.10.2013, p. 738-53.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kurts, C, Panzer, U, Anders, H-J & Rees, AJ 2013, 'The immune system and kidney disease: basic concepts and clinical implications', NAT REV IMMUNOL, vol. 13, no. 10, pp. 738-53. https://doi.org/10.1038/nri3523

APA

Kurts, C., Panzer, U., Anders, H-J., & Rees, A. J. (2013). The immune system and kidney disease: basic concepts and clinical implications. NAT REV IMMUNOL, 13(10), 738-53. https://doi.org/10.1038/nri3523

Vancouver

Kurts C, Panzer U, Anders H-J, Rees AJ. The immune system and kidney disease: basic concepts and clinical implications. NAT REV IMMUNOL. 2013 Oct 1;13(10):738-53. https://doi.org/10.1038/nri3523

Bibtex

@article{0bc6519e067d47058c10b34ed8690961,
title = "The immune system and kidney disease: basic concepts and clinical implications",
abstract = "The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent models and humans have uncovered several underlying mechanisms that can be used to explain the previously enigmatic immunopathology of many kidney diseases. These mechanisms include kidney-specific damage-associated molecular patterns that cause sterile inflammation, the crosstalk between renal dendritic cells and T cells, the development of kidney-targeting autoantibodies and molecular mimicry with microbial pathogens. Conversely, kidney failure affects general immunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease. In this Review, we summarize the recent findings regarding the interactions between the kidneys and the immune system.",
keywords = "Animals, Autoantibodies, Autoantigens, Autoimmunity, Cytokines, Dendritic Cells, Gene Expression, Humans, Immune System, Inflammation, Kidney, Kidney Diseases, T-Lymphocytes",
author = "Christian Kurts and Ulf Panzer and Hans-Joachim Anders and Rees, {Andrew J}",
year = "2013",
month = oct,
day = "1",
doi = "10.1038/nri3523",
language = "English",
volume = "13",
pages = "738--53",
journal = "NAT REV IMMUNOL",
issn = "1474-1733",
publisher = "NATURE PUBLISHING GROUP",
number = "10",

}

RIS

TY - JOUR

T1 - The immune system and kidney disease: basic concepts and clinical implications

AU - Kurts, Christian

AU - Panzer, Ulf

AU - Anders, Hans-Joachim

AU - Rees, Andrew J

PY - 2013/10/1

Y1 - 2013/10/1

N2 - The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent models and humans have uncovered several underlying mechanisms that can be used to explain the previously enigmatic immunopathology of many kidney diseases. These mechanisms include kidney-specific damage-associated molecular patterns that cause sterile inflammation, the crosstalk between renal dendritic cells and T cells, the development of kidney-targeting autoantibodies and molecular mimicry with microbial pathogens. Conversely, kidney failure affects general immunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease. In this Review, we summarize the recent findings regarding the interactions between the kidneys and the immune system.

AB - The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent models and humans have uncovered several underlying mechanisms that can be used to explain the previously enigmatic immunopathology of many kidney diseases. These mechanisms include kidney-specific damage-associated molecular patterns that cause sterile inflammation, the crosstalk between renal dendritic cells and T cells, the development of kidney-targeting autoantibodies and molecular mimicry with microbial pathogens. Conversely, kidney failure affects general immunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease. In this Review, we summarize the recent findings regarding the interactions between the kidneys and the immune system.

KW - Animals

KW - Autoantibodies

KW - Autoantigens

KW - Autoimmunity

KW - Cytokines

KW - Dendritic Cells

KW - Gene Expression

KW - Humans

KW - Immune System

KW - Inflammation

KW - Kidney

KW - Kidney Diseases

KW - T-Lymphocytes

U2 - 10.1038/nri3523

DO - 10.1038/nri3523

M3 - SCORING: Journal article

C2 - 24037418

VL - 13

SP - 738

EP - 753

JO - NAT REV IMMUNOL

JF - NAT REV IMMUNOL

SN - 1474-1733

IS - 10

ER -