The imminent epidemic of atrial fibrillation and its concomitant diseases - Myocardial infarction and heart failure - A cause for concern
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The imminent epidemic of atrial fibrillation and its concomitant diseases - Myocardial infarction and heart failure - A cause for concern. / Börschel, Christin S; Schnabel, Renate B.
In: INT J CARDIOL, Vol. 287, 15.07.2019, p. 162-173.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The imminent epidemic of atrial fibrillation and its concomitant diseases - Myocardial infarction and heart failure - A cause for concern
AU - Börschel, Christin S
AU - Schnabel, Renate B
N1 - Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
PY - 2019/7/15
Y1 - 2019/7/15
N2 - Atrial fibrillation (AF) is increasingly common in the general population. It often coincides with myocardial infarction (MI) and heart failure (HF) which are also diseases in older adults. All three conditions share common cardiovascular risk factors. While hypertension and obesity are central risk factors for all three diseases, smoking and diabetes appear to have less impact on AF. To date, age is the single most important risk factor for AF in the general population. Further, epidemiological studies suggest a strong association of AF to MI and HF. The underlying pathophysiological mechanisms are complex and not fully understood. Both MI and HF can trigger development of AF, mainly by promoting structural and electrical atrial remodeling. On the other hand, AF facilitates HF and MI development via multiple mechanisms, resulting in a vicious circle of cardiac impairment and adverse cardiovascular prognosis. Consequently, to prevent and treat the coincidence of AF and HF or MI a strict optimization of cardiovascular risk factors is required.
AB - Atrial fibrillation (AF) is increasingly common in the general population. It often coincides with myocardial infarction (MI) and heart failure (HF) which are also diseases in older adults. All three conditions share common cardiovascular risk factors. While hypertension and obesity are central risk factors for all three diseases, smoking and diabetes appear to have less impact on AF. To date, age is the single most important risk factor for AF in the general population. Further, epidemiological studies suggest a strong association of AF to MI and HF. The underlying pathophysiological mechanisms are complex and not fully understood. Both MI and HF can trigger development of AF, mainly by promoting structural and electrical atrial remodeling. On the other hand, AF facilitates HF and MI development via multiple mechanisms, resulting in a vicious circle of cardiac impairment and adverse cardiovascular prognosis. Consequently, to prevent and treat the coincidence of AF and HF or MI a strict optimization of cardiovascular risk factors is required.
KW - Atrial Fibrillation/epidemiology
KW - Comorbidity
KW - Global Health
KW - Heart Failure/epidemiology
KW - Humans
KW - Myocardial Infarction/epidemiology
KW - Prognosis
KW - Risk Assessment
KW - Risk Factors
U2 - 10.1016/j.ijcard.2018.11.123
DO - 10.1016/j.ijcard.2018.11.123
M3 - SCORING: Journal article
C2 - 30528622
VL - 287
SP - 162
EP - 173
JO - INT J CARDIOL
JF - INT J CARDIOL
SN - 0167-5273
ER -