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The IMAGEN study: a decade of imaging genetics in adolescents

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The IMAGEN study: a decade of imaging genetics in adolescents. / Mascarell Maričić, Lea; Walter, Henrik; Rosenthal, Annika; Ripke, Stephan; Quinlan, Erin Burke; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Itterman, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Hohmann, Sarah; Smolka, Michael N; Fröhner, Juliane H; Whelan, Robert; Kaminski, Jakob; Schumann, Gunter; Heinz, Andreas; IMAGEN Consortium.

In: MOL PSYCHIATR, Vol. 25, No. 11, 11.2020, p. 2648-2671.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mascarell Maričić, L, Walter, H, Rosenthal, A, Ripke, S, Quinlan, EB, Banaschewski, T, Barker, GJ, Bokde, ALW, Bromberg, U, Büchel, C, Desrivières, S, Flor, H, Frouin, V, Garavan, H, Itterman, B, Martinot, J-L, Martinot, M-LP, Nees, F, Orfanos, DP, Paus, T, Poustka, L, Hohmann, S, Smolka, MN, Fröhner, JH, Whelan, R, Kaminski, J, Schumann, G, Heinz, A & IMAGEN Consortium 2020, 'The IMAGEN study: a decade of imaging genetics in adolescents', MOL PSYCHIATR, vol. 25, no. 11, pp. 2648-2671. https://doi.org/10.1038/s41380-020-0822-5

APA

Mascarell Maričić, L., Walter, H., Rosenthal, A., Ripke, S., Quinlan, E. B., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Bromberg, U., Büchel, C., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Itterman, B., Martinot, J-L., Martinot, M-L. P., Nees, F., Orfanos, D. P., ... IMAGEN Consortium (2020). The IMAGEN study: a decade of imaging genetics in adolescents. MOL PSYCHIATR, 25(11), 2648-2671. https://doi.org/10.1038/s41380-020-0822-5

Vancouver

Mascarell Maričić L, Walter H, Rosenthal A, Ripke S, Quinlan EB, Banaschewski T et al. The IMAGEN study: a decade of imaging genetics in adolescents. MOL PSYCHIATR. 2020 Nov;25(11):2648-2671. https://doi.org/10.1038/s41380-020-0822-5

Bibtex

@article{8529d5ce8e464a6abe22e25812a6cc4f,
title = "The IMAGEN study: a decade of imaging genetics in adolescents",
abstract = "Imaging genetics offers the possibility of detecting associations between genotype and brain structure as well as function, with effect sizes potentially exceeding correlations between genotype and behavior. However, study results are often limited due to small sample sizes and methodological differences, thus reducing the reliability of findings. The IMAGEN cohort with 2000 young adolescents assessed from the age of 14 onwards tries to eliminate some of these limitations by offering a longitudinal approach and sufficient sample size for analyzing gene-environment interactions on brain structure and function. Here, we give a systematic review of IMAGEN publications since the start of the consortium. We then focus on the specific phenotype 'drug use' to illustrate the potential of the IMAGEN approach. We describe findings with respect to frontocortical, limbic and striatal brain volume, functional activation elicited by reward anticipation, behavioral inhibition, and affective faces, and their respective associations with drug intake. In addition to describing its strengths, we also discuss limitations of the IMAGEN study. Because of the longitudinal design and related attrition, analyses are underpowered for (epi-) genome-wide approaches due to the limited sample size. Estimating the generalizability of results requires replications in independent samples. However, such densely phenotyped longitudinal studies are still rare and alternative internal cross-validation methods (e.g., leave-one out, split-half) are also warranted. In conclusion, the IMAGEN cohort is a unique, very well characterized longitudinal sample, which helped to elucidate neurobiological mechanisms involved in complex behavior and offers the possibility to further disentangle genotype × phenotype interactions.",
keywords = "Adolescent, Adolescent Behavior, Cohort Studies, Genetics, Humans, Multicenter Studies as Topic, Neuroimaging, Reproducibility of Results, Reward, Time Factors",
author = "{Mascarell Mari{\v c}i{\'c}}, Lea and Henrik Walter and Annika Rosenthal and Stephan Ripke and Quinlan, {Erin Burke} and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and Hugh Garavan and Bernd Itterman and Jean-Luc Martinot and Martinot, {Marie-Laure Paill{\`e}re} and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Tom{\'a}{\v s} Paus and Luise Poustka and Sarah Hohmann and Smolka, {Michael N} and Fr{\"o}hner, {Juliane H} and Robert Whelan and Jakob Kaminski and Gunter Schumann and Andreas Heinz and {IMAGEN Consortium}",
year = "2020",
month = nov,
doi = "10.1038/s41380-020-0822-5",
language = "English",
volume = "25",
pages = "2648--2671",
journal = "MOL PSYCHIATR",
issn = "1359-4184",
publisher = "NATURE PUBLISHING GROUP",
number = "11",

}

RIS

TY - JOUR

T1 - The IMAGEN study: a decade of imaging genetics in adolescents

AU - Mascarell Maričić, Lea

AU - Walter, Henrik

AU - Rosenthal, Annika

AU - Ripke, Stephan

AU - Quinlan, Erin Burke

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Garavan, Hugh

AU - Itterman, Bernd

AU - Martinot, Jean-Luc

AU - Martinot, Marie-Laure Paillère

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Hohmann, Sarah

AU - Smolka, Michael N

AU - Fröhner, Juliane H

AU - Whelan, Robert

AU - Kaminski, Jakob

AU - Schumann, Gunter

AU - Heinz, Andreas

AU - IMAGEN Consortium

PY - 2020/11

Y1 - 2020/11

N2 - Imaging genetics offers the possibility of detecting associations between genotype and brain structure as well as function, with effect sizes potentially exceeding correlations between genotype and behavior. However, study results are often limited due to small sample sizes and methodological differences, thus reducing the reliability of findings. The IMAGEN cohort with 2000 young adolescents assessed from the age of 14 onwards tries to eliminate some of these limitations by offering a longitudinal approach and sufficient sample size for analyzing gene-environment interactions on brain structure and function. Here, we give a systematic review of IMAGEN publications since the start of the consortium. We then focus on the specific phenotype 'drug use' to illustrate the potential of the IMAGEN approach. We describe findings with respect to frontocortical, limbic and striatal brain volume, functional activation elicited by reward anticipation, behavioral inhibition, and affective faces, and their respective associations with drug intake. In addition to describing its strengths, we also discuss limitations of the IMAGEN study. Because of the longitudinal design and related attrition, analyses are underpowered for (epi-) genome-wide approaches due to the limited sample size. Estimating the generalizability of results requires replications in independent samples. However, such densely phenotyped longitudinal studies are still rare and alternative internal cross-validation methods (e.g., leave-one out, split-half) are also warranted. In conclusion, the IMAGEN cohort is a unique, very well characterized longitudinal sample, which helped to elucidate neurobiological mechanisms involved in complex behavior and offers the possibility to further disentangle genotype × phenotype interactions.

AB - Imaging genetics offers the possibility of detecting associations between genotype and brain structure as well as function, with effect sizes potentially exceeding correlations between genotype and behavior. However, study results are often limited due to small sample sizes and methodological differences, thus reducing the reliability of findings. The IMAGEN cohort with 2000 young adolescents assessed from the age of 14 onwards tries to eliminate some of these limitations by offering a longitudinal approach and sufficient sample size for analyzing gene-environment interactions on brain structure and function. Here, we give a systematic review of IMAGEN publications since the start of the consortium. We then focus on the specific phenotype 'drug use' to illustrate the potential of the IMAGEN approach. We describe findings with respect to frontocortical, limbic and striatal brain volume, functional activation elicited by reward anticipation, behavioral inhibition, and affective faces, and their respective associations with drug intake. In addition to describing its strengths, we also discuss limitations of the IMAGEN study. Because of the longitudinal design and related attrition, analyses are underpowered for (epi-) genome-wide approaches due to the limited sample size. Estimating the generalizability of results requires replications in independent samples. However, such densely phenotyped longitudinal studies are still rare and alternative internal cross-validation methods (e.g., leave-one out, split-half) are also warranted. In conclusion, the IMAGEN cohort is a unique, very well characterized longitudinal sample, which helped to elucidate neurobiological mechanisms involved in complex behavior and offers the possibility to further disentangle genotype × phenotype interactions.

KW - Adolescent

KW - Adolescent Behavior

KW - Cohort Studies

KW - Genetics

KW - Humans

KW - Multicenter Studies as Topic

KW - Neuroimaging

KW - Reproducibility of Results

KW - Reward

KW - Time Factors

U2 - 10.1038/s41380-020-0822-5

DO - 10.1038/s41380-020-0822-5

M3 - SCORING: Journal article

C2 - 32601453

VL - 25

SP - 2648

EP - 2671

JO - MOL PSYCHIATR

JF - MOL PSYCHIATR

SN - 1359-4184

IS - 11

ER -