The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19
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The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19. / Schultheiß, Christoph; Willscher, Edith; Paschold, Lisa; Gottschick, Cornelia; Klee, Bianca; Henkes, Svenja-Sibylla; Bosurgi, Lidia; Dutzmann, Jochen; Sedding, Daniel; Frese, Thomas; Girndt, Matthias; Höll, Jessica; Gekle, Michael; Mikolajczyk, Rafael; Binder, Mascha.
In: CELL REP MED, Vol. 3, No. 6, 100663, 21.06.2022, p. 100663.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19
AU - Schultheiß, Christoph
AU - Willscher, Edith
AU - Paschold, Lisa
AU - Gottschick, Cornelia
AU - Klee, Bianca
AU - Henkes, Svenja-Sibylla
AU - Bosurgi, Lidia
AU - Dutzmann, Jochen
AU - Sedding, Daniel
AU - Frese, Thomas
AU - Girndt, Matthias
AU - Höll, Jessica
AU - Gekle, Michael
AU - Mikolajczyk, Rafael
AU - Binder, Mascha
PY - 2022/6/21
Y1 - 2022/6/21
N2 - Post-acute sequelae of COVID-19 (PASC) is emerging as global problem with unknown molecular drivers. Using a digital epidemiology approach, we recruited 8,077 individuals to the cohort study for digital health research in Germany (DigiHero) to respond to a basic questionnaire followed by a PASC-focused survey and blood sampling. We report the first 318 participants, the majority thereof after mild infections. Of those, 67.8% report PASC, predominantly consisting of fatigue, dyspnea, and concentration deficit, which persists in 60% over the mean 8-month follow-up period and resolves independently of post-infection vaccination. PASC is not associated with autoantibodies, but with elevated IL-1β, IL-6, and TNF plasma levels, which we confirm in a validation cohort with 333 additional participants and a longer time from infection of 10 months. Blood profiling and single-cell data from early infection suggest the induction of these cytokines in COVID-19 lung pro-inflammatory macrophages creating a self-sustaining feedback loop.
AB - Post-acute sequelae of COVID-19 (PASC) is emerging as global problem with unknown molecular drivers. Using a digital epidemiology approach, we recruited 8,077 individuals to the cohort study for digital health research in Germany (DigiHero) to respond to a basic questionnaire followed by a PASC-focused survey and blood sampling. We report the first 318 participants, the majority thereof after mild infections. Of those, 67.8% report PASC, predominantly consisting of fatigue, dyspnea, and concentration deficit, which persists in 60% over the mean 8-month follow-up period and resolves independently of post-infection vaccination. PASC is not associated with autoantibodies, but with elevated IL-1β, IL-6, and TNF plasma levels, which we confirm in a validation cohort with 333 additional participants and a longer time from infection of 10 months. Blood profiling and single-cell data from early infection suggest the induction of these cytokines in COVID-19 lung pro-inflammatory macrophages creating a self-sustaining feedback loop.
U2 - 10.1016/j.xcrm.2022.100663
DO - 10.1016/j.xcrm.2022.100663
M3 - SCORING: Journal article
C2 - 35732153
VL - 3
SP - 100663
JO - CELL REP MED
JF - CELL REP MED
SN - 2666-3791
IS - 6
M1 - 100663
ER -