The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation.
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The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation. / Schmidt, Katy; Schinke, Thorsten; Haberland, Michael; Priemel, Matthias; Schilling, Arndt; Erdmann, Cordula; Rueger, Johannes M; Sock, Elisabeth; Wegner, Michael; Amling, Michael.
In: J CELL BIOL, Vol. 168, No. 6, 6, 2005, p. 899-910.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation.
AU - Schmidt, Katy
AU - Schinke, Thorsten
AU - Haberland, Michael
AU - Priemel, Matthias
AU - Schilling, Arndt
AU - Erdmann, Cordula
AU - Rueger, Johannes M
AU - Sock, Elisabeth
AU - Wegner, Michael
AU - Amling, Michael
PY - 2005
Y1 - 2005
N2 - Bone remodeling is an important physiologic process that is required to maintain a constant bone mass. This is achieved through a balanced activity of bone-resorbing osteoclasts and bone-forming osteoblasts. In this study, we identify the high mobility group transcription factor Sox8 as a physiologic regulator of bone formation. Sox8-deficient mice display a low bone mass phenotype that is caused by a precocious osteoblast differentiation. Accordingly, primary osteoblasts derived from these mice show an accelerated mineralization ex vivo and a premature expression of osteoblast differentiation markers. To confirm the function of Sox8 as a negative regulator of osteoblast differentiation we generated transgenic mice that express Sox8 under the control of an osteoblast-specific Col1a1 promoter fragment. These mice display a severely impaired bone formation that can be explained by a strongly reduced expression of runt-related transcription factor 2, a gene encoding a transcription factor required for osteoblast differentiation. Together, these data demonstrate a novel function of Sox8, whose tightly controlled expression is critical for bone formation.
AB - Bone remodeling is an important physiologic process that is required to maintain a constant bone mass. This is achieved through a balanced activity of bone-resorbing osteoclasts and bone-forming osteoblasts. In this study, we identify the high mobility group transcription factor Sox8 as a physiologic regulator of bone formation. Sox8-deficient mice display a low bone mass phenotype that is caused by a precocious osteoblast differentiation. Accordingly, primary osteoblasts derived from these mice show an accelerated mineralization ex vivo and a premature expression of osteoblast differentiation markers. To confirm the function of Sox8 as a negative regulator of osteoblast differentiation we generated transgenic mice that express Sox8 under the control of an osteoblast-specific Col1a1 promoter fragment. These mice display a severely impaired bone formation that can be explained by a strongly reduced expression of runt-related transcription factor 2, a gene encoding a transcription factor required for osteoblast differentiation. Together, these data demonstrate a novel function of Sox8, whose tightly controlled expression is critical for bone formation.
M3 - SCORING: Zeitschriftenaufsatz
VL - 168
SP - 899
EP - 910
JO - J CELL BIOL
JF - J CELL BIOL
SN - 0021-9525
IS - 6
M1 - 6
ER -
