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The hair follicle-psoriasis axis: Shared regulatory mechanisms and therapeutic targets

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The hair follicle-psoriasis axis: Shared regulatory mechanisms and therapeutic targets. / Suzuki, Takahiro; Ito, Taisuke; Gilhar, Amos; Tokura, Yoshiki; Reich, Kristian; Paus, R.

In: EXP DERMATOL, Vol. 31, No. 3, 03.2022, p. 266-279.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Suzuki, T, Ito, T, Gilhar, A, Tokura, Y, Reich, K & Paus, R 2022, 'The hair follicle-psoriasis axis: Shared regulatory mechanisms and therapeutic targets', EXP DERMATOL, vol. 31, no. 3, pp. 266-279. https://doi.org/10.1111/exd.14462

APA

Suzuki, T., Ito, T., Gilhar, A., Tokura, Y., Reich, K., & Paus, R. (2022). The hair follicle-psoriasis axis: Shared regulatory mechanisms and therapeutic targets. EXP DERMATOL, 31(3), 266-279. https://doi.org/10.1111/exd.14462

Vancouver

Suzuki T, Ito T, Gilhar A, Tokura Y, Reich K, Paus R. The hair follicle-psoriasis axis: Shared regulatory mechanisms and therapeutic targets. EXP DERMATOL. 2022 Mar;31(3):266-279. https://doi.org/10.1111/exd.14462

Bibtex

@article{b08780da971f48fbbb22c63b69cf4059,
title = "The hair follicle-psoriasis axis: Shared regulatory mechanisms and therapeutic targets",
abstract = "It has long been known that there is a special affinity of psoriasis for the scalp: Here, it occurs most frequently, lesions terminate sharply in frontal skin beyond the hair line and are difficult to treat. Yet, surprisingly, scalp psoriasis only rarely causes alopecia, even though the pilosebaceous unit clearly is affected. Here, we systematically explore the peculiar, insufficiently investigated connection between psoriasis and growing (anagen) terminal scalp hair follicles (HFs), with emphasis on shared regulatory mechanism and therapeutic targets. Interestingly, several drugs and stressors that can trigger/aggravate psoriasis can inhibit hair growth (e.g. beta-blockers, chloroquine, carbamazepine, interferon-alpha, perceived stress). Instead, several anti-psoriatic agents can stimulate hair growth (e.g. cyclosporine, glucocorticoids, dithranol, UV irradiation), while skin/HF trauma (K{\"o}bner phenomenon/depilation) favours the development of psoriatic lesions and induces anagen in {"}quiescent{"} (telogen) HFs. On this basis, we propose two interconnected working models: (a) the existence of a bidirectional {"}hair follicle-psoriasis axis,{"} along which keratinocytes of anagen scalp HFs secrete signals that favour the development and maintenance of psoriatic scalp lesions and respond to signals from these lesions, and (b) that anagen induction and psoriatic lesions share molecular {"}switch-on{"} mechanisms, which invite pharmacological targeting, once identified. Therefore, we advocate a novel, cross-fertilizing and integrative approach to psoriasis and hair research that systematically characterizes the {"}HF-psoriasis axis,{"} focused on identification and therapeutic targeting of selected, shared signalling pathways in the future management of both, psoriasis and hair growth disorders.",
keywords = "Alopecia/drug therapy, Hair, Hair Follicle/metabolism, Humans, Psoriasis/metabolism, Scalp/pathology",
author = "Takahiro Suzuki and Taisuke Ito and Amos Gilhar and Yoshiki Tokura and Kristian Reich and R Paus",
note = "{\textcopyright} 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2022",
month = mar,
doi = "10.1111/exd.14462",
language = "English",
volume = "31",
pages = "266--279",
journal = "EXP DERMATOL",
issn = "0906-6705",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - The hair follicle-psoriasis axis: Shared regulatory mechanisms and therapeutic targets

AU - Suzuki, Takahiro

AU - Ito, Taisuke

AU - Gilhar, Amos

AU - Tokura, Yoshiki

AU - Reich, Kristian

AU - Paus, R

N1 - © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2022/3

Y1 - 2022/3

N2 - It has long been known that there is a special affinity of psoriasis for the scalp: Here, it occurs most frequently, lesions terminate sharply in frontal skin beyond the hair line and are difficult to treat. Yet, surprisingly, scalp psoriasis only rarely causes alopecia, even though the pilosebaceous unit clearly is affected. Here, we systematically explore the peculiar, insufficiently investigated connection between psoriasis and growing (anagen) terminal scalp hair follicles (HFs), with emphasis on shared regulatory mechanism and therapeutic targets. Interestingly, several drugs and stressors that can trigger/aggravate psoriasis can inhibit hair growth (e.g. beta-blockers, chloroquine, carbamazepine, interferon-alpha, perceived stress). Instead, several anti-psoriatic agents can stimulate hair growth (e.g. cyclosporine, glucocorticoids, dithranol, UV irradiation), while skin/HF trauma (Köbner phenomenon/depilation) favours the development of psoriatic lesions and induces anagen in "quiescent" (telogen) HFs. On this basis, we propose two interconnected working models: (a) the existence of a bidirectional "hair follicle-psoriasis axis," along which keratinocytes of anagen scalp HFs secrete signals that favour the development and maintenance of psoriatic scalp lesions and respond to signals from these lesions, and (b) that anagen induction and psoriatic lesions share molecular "switch-on" mechanisms, which invite pharmacological targeting, once identified. Therefore, we advocate a novel, cross-fertilizing and integrative approach to psoriasis and hair research that systematically characterizes the "HF-psoriasis axis," focused on identification and therapeutic targeting of selected, shared signalling pathways in the future management of both, psoriasis and hair growth disorders.

AB - It has long been known that there is a special affinity of psoriasis for the scalp: Here, it occurs most frequently, lesions terminate sharply in frontal skin beyond the hair line and are difficult to treat. Yet, surprisingly, scalp psoriasis only rarely causes alopecia, even though the pilosebaceous unit clearly is affected. Here, we systematically explore the peculiar, insufficiently investigated connection between psoriasis and growing (anagen) terminal scalp hair follicles (HFs), with emphasis on shared regulatory mechanism and therapeutic targets. Interestingly, several drugs and stressors that can trigger/aggravate psoriasis can inhibit hair growth (e.g. beta-blockers, chloroquine, carbamazepine, interferon-alpha, perceived stress). Instead, several anti-psoriatic agents can stimulate hair growth (e.g. cyclosporine, glucocorticoids, dithranol, UV irradiation), while skin/HF trauma (Köbner phenomenon/depilation) favours the development of psoriatic lesions and induces anagen in "quiescent" (telogen) HFs. On this basis, we propose two interconnected working models: (a) the existence of a bidirectional "hair follicle-psoriasis axis," along which keratinocytes of anagen scalp HFs secrete signals that favour the development and maintenance of psoriatic scalp lesions and respond to signals from these lesions, and (b) that anagen induction and psoriatic lesions share molecular "switch-on" mechanisms, which invite pharmacological targeting, once identified. Therefore, we advocate a novel, cross-fertilizing and integrative approach to psoriasis and hair research that systematically characterizes the "HF-psoriasis axis," focused on identification and therapeutic targeting of selected, shared signalling pathways in the future management of both, psoriasis and hair growth disorders.

KW - Alopecia/drug therapy

KW - Hair

KW - Hair Follicle/metabolism

KW - Humans

KW - Psoriasis/metabolism

KW - Scalp/pathology

U2 - 10.1111/exd.14462

DO - 10.1111/exd.14462

M3 - SCORING: Review article

C2 - 34587317

VL - 31

SP - 266

EP - 279

JO - EXP DERMATOL

JF - EXP DERMATOL

SN - 0906-6705

IS - 3

ER -