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The functional relevance of passenger leukocytes and microchimerism for heart allograft acceptance in the rat.

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The functional relevance of passenger leukocytes and microchimerism for heart allograft acceptance in the rat. / Ko, S; Deiwick, A; Jäger, M D; Dinkel, A; Rohde, F; Fischer, R; Tsui, Tung Yu; Rittmann, K L; Wonigeit, K; Schlitt, H J.

In: NAT MED, Vol. 5, No. 11, 11, 1999, p. 1292-1297.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ko, S, Deiwick, A, Jäger, MD, Dinkel, A, Rohde, F, Fischer, R, Tsui, TY, Rittmann, KL, Wonigeit, K & Schlitt, HJ 1999, 'The functional relevance of passenger leukocytes and microchimerism for heart allograft acceptance in the rat.', NAT MED, vol. 5, no. 11, 11, pp. 1292-1297. <http://www.ncbi.nlm.nih.gov/pubmed/10545996?dopt=Citation>

APA

Ko, S., Deiwick, A., Jäger, M. D., Dinkel, A., Rohde, F., Fischer, R., Tsui, T. Y., Rittmann, K. L., Wonigeit, K., & Schlitt, H. J. (1999). The functional relevance of passenger leukocytes and microchimerism for heart allograft acceptance in the rat. NAT MED, 5(11), 1292-1297. [11]. http://www.ncbi.nlm.nih.gov/pubmed/10545996?dopt=Citation

Vancouver

Ko S, Deiwick A, Jäger MD, Dinkel A, Rohde F, Fischer R et al. The functional relevance of passenger leukocytes and microchimerism for heart allograft acceptance in the rat. NAT MED. 1999;5(11):1292-1297. 11.

Bibtex

@article{3a225660cd46431e9e49d32418baa7cd,
title = "The functional relevance of passenger leukocytes and microchimerism for heart allograft acceptance in the rat.",
abstract = "With an organ transplant, hematopoietic donor cells are transferred to the recipient. To study the relevance of the resulting microchimerism for allograft acceptance, we analyzed a rat model of cyclosporine-induced tolerance for strongly incompatible heart allografts. Using a monoclonal antibody that detects a donor-specific CD45 allotype (RT7a), we selectively depleted donor leukocytes at different times after transplantation (days 0 or 18). Depletion was similarly effective at both times. However, only depletion on day 0 prevented tolerance induction and was associated with severe acute or chronic graft rejection. This indicates that passenger leukocytes have an essential immunomodulatory effect on the induction phase of allograft acceptance.",
author = "S Ko and A Deiwick and J{\"a}ger, {M D} and A Dinkel and F Rohde and R Fischer and Tsui, {Tung Yu} and Rittmann, {K L} and K Wonigeit and Schlitt, {H J}",
year = "1999",
language = "Deutsch",
volume = "5",
pages = "1292--1297",
journal = "NAT MED",
issn = "1078-8956",
publisher = "NATURE PUBLISHING GROUP",
number = "11",

}

RIS

TY - JOUR

T1 - The functional relevance of passenger leukocytes and microchimerism for heart allograft acceptance in the rat.

AU - Ko, S

AU - Deiwick, A

AU - Jäger, M D

AU - Dinkel, A

AU - Rohde, F

AU - Fischer, R

AU - Tsui, Tung Yu

AU - Rittmann, K L

AU - Wonigeit, K

AU - Schlitt, H J

PY - 1999

Y1 - 1999

N2 - With an organ transplant, hematopoietic donor cells are transferred to the recipient. To study the relevance of the resulting microchimerism for allograft acceptance, we analyzed a rat model of cyclosporine-induced tolerance for strongly incompatible heart allografts. Using a monoclonal antibody that detects a donor-specific CD45 allotype (RT7a), we selectively depleted donor leukocytes at different times after transplantation (days 0 or 18). Depletion was similarly effective at both times. However, only depletion on day 0 prevented tolerance induction and was associated with severe acute or chronic graft rejection. This indicates that passenger leukocytes have an essential immunomodulatory effect on the induction phase of allograft acceptance.

AB - With an organ transplant, hematopoietic donor cells are transferred to the recipient. To study the relevance of the resulting microchimerism for allograft acceptance, we analyzed a rat model of cyclosporine-induced tolerance for strongly incompatible heart allografts. Using a monoclonal antibody that detects a donor-specific CD45 allotype (RT7a), we selectively depleted donor leukocytes at different times after transplantation (days 0 or 18). Depletion was similarly effective at both times. However, only depletion on day 0 prevented tolerance induction and was associated with severe acute or chronic graft rejection. This indicates that passenger leukocytes have an essential immunomodulatory effect on the induction phase of allograft acceptance.

M3 - SCORING: Zeitschriftenaufsatz

VL - 5

SP - 1292

EP - 1297

JO - NAT MED

JF - NAT MED

SN - 1078-8956

IS - 11

M1 - 11

ER -