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The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.

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The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. / Napoli, Ilaria; Mercaldo, Valentina; Boyl, Pietro Pilo; Eleuteri, Boris; Zalfa, Francesca; Silvia, De Rubeis; Daniele, Di Marino; Mohr, Evita; Massimi, Marzia; Falconi, Mattia; Witke, Walter; Costa-Mattioli, Mauro; Sonenberg, Nahum; Achsel, Tilmann; Bagni, Claudia.

In: CELL, Vol. 134, No. 6, 6, 2008, p. 1042-1054.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Napoli, I, Mercaldo, V, Boyl, PP, Eleuteri, B, Zalfa, F, Silvia, DR, Daniele, DM, Mohr, E, Massimi, M, Falconi, M, Witke, W, Costa-Mattioli, M, Sonenberg, N, Achsel, T & Bagni, C 2008, 'The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.', CELL, vol. 134, no. 6, 6, pp. 1042-1054. <http://www.ncbi.nlm.nih.gov/pubmed/18805096?dopt=Citation>

APA

Napoli, I., Mercaldo, V., Boyl, P. P., Eleuteri, B., Zalfa, F., Silvia, D. R., Daniele, D. M., Mohr, E., Massimi, M., Falconi, M., Witke, W., Costa-Mattioli, M., Sonenberg, N., Achsel, T., & Bagni, C. (2008). The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. CELL, 134(6), 1042-1054. [6]. http://www.ncbi.nlm.nih.gov/pubmed/18805096?dopt=Citation

Vancouver

Napoli I, Mercaldo V, Boyl PP, Eleuteri B, Zalfa F, Silvia DR et al. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. CELL. 2008;134(6):1042-1054. 6.

Bibtex

@article{b04366b08ab4478cb3eb1f5ad1a1563a,
title = "The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.",
abstract = "Strong evidence indicates that regulated mRNA translation in neuronal dendrites underlies synaptic plasticity and brain development. The fragile X mental retardation protein (FMRP) is involved in this process; here, we show that it acts by inhibiting translation initiation. A binding partner of FMRP, CYFIP1/Sra1, directly binds the translation initiation factor eIF4E through a domain that is structurally related to those present in 4E-BP translational inhibitors. Brain cytoplasmic RNA 1 (BC1), another FMRP binding partner, increases the affinity of FMRP for the CYFIP1-eIF4E complex in the brain. Levels of proteins encoded by known FMRP target mRNAs are increased upon reduction of CYFIP1 in neurons. Translational repression is regulated in an activity-dependent manner because BDNF or DHPG stimulation of neurons causes CYFIP1 to dissociate from eIF4E at synapses, thereby resulting in protein synthesis. Thus, the translational repression activity of FMRP in the brain is mediated, at least in part, by CYFIP1.",
author = "Ilaria Napoli and Valentina Mercaldo and Boyl, {Pietro Pilo} and Boris Eleuteri and Francesca Zalfa and Silvia, {De Rubeis} and Daniele, {Di Marino} and Evita Mohr and Marzia Massimi and Mattia Falconi and Walter Witke and Mauro Costa-Mattioli and Nahum Sonenberg and Tilmann Achsel and Claudia Bagni",
year = "2008",
language = "Deutsch",
volume = "134",
pages = "1042--1054",
journal = "CELL",
issn = "0092-8674",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.

AU - Napoli, Ilaria

AU - Mercaldo, Valentina

AU - Boyl, Pietro Pilo

AU - Eleuteri, Boris

AU - Zalfa, Francesca

AU - Silvia, De Rubeis

AU - Daniele, Di Marino

AU - Mohr, Evita

AU - Massimi, Marzia

AU - Falconi, Mattia

AU - Witke, Walter

AU - Costa-Mattioli, Mauro

AU - Sonenberg, Nahum

AU - Achsel, Tilmann

AU - Bagni, Claudia

PY - 2008

Y1 - 2008

N2 - Strong evidence indicates that regulated mRNA translation in neuronal dendrites underlies synaptic plasticity and brain development. The fragile X mental retardation protein (FMRP) is involved in this process; here, we show that it acts by inhibiting translation initiation. A binding partner of FMRP, CYFIP1/Sra1, directly binds the translation initiation factor eIF4E through a domain that is structurally related to those present in 4E-BP translational inhibitors. Brain cytoplasmic RNA 1 (BC1), another FMRP binding partner, increases the affinity of FMRP for the CYFIP1-eIF4E complex in the brain. Levels of proteins encoded by known FMRP target mRNAs are increased upon reduction of CYFIP1 in neurons. Translational repression is regulated in an activity-dependent manner because BDNF or DHPG stimulation of neurons causes CYFIP1 to dissociate from eIF4E at synapses, thereby resulting in protein synthesis. Thus, the translational repression activity of FMRP in the brain is mediated, at least in part, by CYFIP1.

AB - Strong evidence indicates that regulated mRNA translation in neuronal dendrites underlies synaptic plasticity and brain development. The fragile X mental retardation protein (FMRP) is involved in this process; here, we show that it acts by inhibiting translation initiation. A binding partner of FMRP, CYFIP1/Sra1, directly binds the translation initiation factor eIF4E through a domain that is structurally related to those present in 4E-BP translational inhibitors. Brain cytoplasmic RNA 1 (BC1), another FMRP binding partner, increases the affinity of FMRP for the CYFIP1-eIF4E complex in the brain. Levels of proteins encoded by known FMRP target mRNAs are increased upon reduction of CYFIP1 in neurons. Translational repression is regulated in an activity-dependent manner because BDNF or DHPG stimulation of neurons causes CYFIP1 to dissociate from eIF4E at synapses, thereby resulting in protein synthesis. Thus, the translational repression activity of FMRP in the brain is mediated, at least in part, by CYFIP1.

M3 - SCORING: Zeitschriftenaufsatz

VL - 134

SP - 1042

EP - 1054

JO - CELL

JF - CELL

SN - 0092-8674

IS - 6

M1 - 6

ER -