The extracts of some marine invertebrates and algae collected off the coast waters of vietnam induce the inhibitory effects on the activator protein-1 transcriptional activity in JB6 Cl41 cells
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The extracts of some marine invertebrates and algae collected off the coast waters of vietnam induce the inhibitory effects on the activator protein-1 transcriptional activity in JB6 Cl41 cells. / Fedorov, S. N.; Krasokhin, V. B.; Shubina, L. K.; Dyshlovoy, S. A.; Nam, N. H.; Minh, C. V.
In: Journal of Chemistry, 2013.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The extracts of some marine invertebrates and algae collected off the coast waters of vietnam induce the inhibitory effects on the activator protein-1 transcriptional activity in JB6 Cl41 cells
AU - Fedorov, S. N.
AU - Krasokhin, V. B.
AU - Shubina, L. K.
AU - Dyshlovoy, S. A.
AU - Nam, N. H.
AU - Minh, C. V.
N1 - Copyright: Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - It has previously been shown that inhibition of the transcriptional activity of the oncogenic nuclear factor AP-1 can result in cancer prevention. Marine invertebrates and alga are a rich source of natural compounds that possess various biological activities. The inhibitory effects of the extracts of Vietnamese marine organisms in relation to the AP-1 transcriptional activity were examined by the luciferase method using JB6 Cl41 cells stably expressing a luciferase reporter gene controlled by AP-1 DNA binding sequence. As was found, 71 species of marine sponges out of 148 species studied contain inhibitors of the AP-1 transcriptional activity. Therefore, marine organisms as a source of biologically active compounds have a great potential for isolation of the new cancer preventive compounds that inhibit the oncogenic AP-1 nuclear factor.
AB - It has previously been shown that inhibition of the transcriptional activity of the oncogenic nuclear factor AP-1 can result in cancer prevention. Marine invertebrates and alga are a rich source of natural compounds that possess various biological activities. The inhibitory effects of the extracts of Vietnamese marine organisms in relation to the AP-1 transcriptional activity were examined by the luciferase method using JB6 Cl41 cells stably expressing a luciferase reporter gene controlled by AP-1 DNA binding sequence. As was found, 71 species of marine sponges out of 148 species studied contain inhibitors of the AP-1 transcriptional activity. Therefore, marine organisms as a source of biologically active compounds have a great potential for isolation of the new cancer preventive compounds that inhibit the oncogenic AP-1 nuclear factor.
UR - http://www.scopus.com/inward/record.url?scp=84873403772&partnerID=8YFLogxK
U2 - 10.1155/2013/896709
DO - 10.1155/2013/896709
M3 - SCORING: Journal article
AN - SCOPUS:84873403772
JO - J CHEM-NY
JF - J CHEM-NY
SN - 2090-9063
M1 - 896709
ER -
