The epithelial framework of the thymus in normal and pathological conditions. Immunohistochemical demonstration of keratin in an autopsy series.
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The epithelial framework of the thymus in normal and pathological conditions. Immunohistochemical demonstration of keratin in an autopsy series. / Löning, Thomas; Caselitz, J; Otto, H F.
In: Virchows Arch A Pathol Anat Histopathol, Vol. 392, No. 1, 1, 1981, p. 7-20.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The epithelial framework of the thymus in normal and pathological conditions. Immunohistochemical demonstration of keratin in an autopsy series.
AU - Löning, Thomas
AU - Caselitz, J
AU - Otto, H F
PY - 1981
Y1 - 1981
N2 - Autopsy specimens of normal human thymus, from cases of accidental involution, follicular hyperplasia, thymomas and a teratoma were investigated by immunocytochemistry using specific immune sera to small and large keratins. Keratin antisera represent a "marker" of both Hassall's corpuscles (HC) and so-called epithelial reticular cells. There were no apparent differences in keratin polypeptides distribution between cortical and medullary thymic epithelial cells. In accidental involution, the epithelial framework became prominent: epithelial cortical borders and epithelial perivascular sheaths appeared often to be discontinuous structure. The central and occasionally cystic spaces of HC did not react with keratin antisera. In follicular hyperplasia, almost solid epithelial aggregates were seen which were located around germinal centers. In thymic tumours, neoplastic epithelial cells displayed a marked immunoreactivity with keratin antisera. Immune sera against keratin filaments represent an interesting tool in thymus research and in the diagnostic pathology of thymic tumours.
AB - Autopsy specimens of normal human thymus, from cases of accidental involution, follicular hyperplasia, thymomas and a teratoma were investigated by immunocytochemistry using specific immune sera to small and large keratins. Keratin antisera represent a "marker" of both Hassall's corpuscles (HC) and so-called epithelial reticular cells. There were no apparent differences in keratin polypeptides distribution between cortical and medullary thymic epithelial cells. In accidental involution, the epithelial framework became prominent: epithelial cortical borders and epithelial perivascular sheaths appeared often to be discontinuous structure. The central and occasionally cystic spaces of HC did not react with keratin antisera. In follicular hyperplasia, almost solid epithelial aggregates were seen which were located around germinal centers. In thymic tumours, neoplastic epithelial cells displayed a marked immunoreactivity with keratin antisera. Immune sera against keratin filaments represent an interesting tool in thymus research and in the diagnostic pathology of thymic tumours.
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Child
KW - Child, Preschool
KW - Infant
KW - Infant, Newborn
KW - Immunoenzyme Techniques
KW - Histocytochemistry
KW - Autopsy
KW - Epithelium/analysis
KW - Hyperplasia
KW - Keratins/analysis
KW - Teratoma/pathology
KW - Thymoma/pathology
KW - Thymus Gland/pathology
KW - Thymus Neoplasms/pathology
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Child
KW - Child, Preschool
KW - Infant
KW - Infant, Newborn
KW - Immunoenzyme Techniques
KW - Histocytochemistry
KW - Autopsy
KW - Epithelium/analysis
KW - Hyperplasia
KW - Keratins/analysis
KW - Teratoma/pathology
KW - Thymoma/pathology
KW - Thymus Gland/pathology
KW - Thymus Neoplasms/pathology
M3 - SCORING: Journal article
VL - 392
SP - 7
EP - 20
JO - VIRCHOWS ARCH
JF - VIRCHOWS ARCH
SN - 0945-6317
IS - 1
M1 - 1
ER -
