The endocrine function of adipose tissues in health and cardiometabolic disease
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The endocrine function of adipose tissues in health and cardiometabolic disease. / Scheja, Ludger; Heeren, Joerg.
In: NAT REV ENDOCRINOL, Vol. 15, No. 9, 09.2019, p. 507-524.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - The endocrine function of adipose tissues in health and cardiometabolic disease
AU - Scheja, Ludger
AU - Heeren, Joerg
PY - 2019/9
Y1 - 2019/9
N2 - In addition to their role in glucose and lipid metabolism, adipocytes respond differentially to physiological cues or metabolic stress by releasing endocrine factors that regulate diverse processes, such as energy expenditure, appetite control, glucose homeostasis, insulin sensitivity, inflammation and tissue repair. Both energy-storing white adipocytes and thermogenic brown and beige adipocytes secrete hormones, which can be peptides (adipokines), lipids (lipokines) and exosomal microRNAs. Some of these factors have defined targets; for example, adiponectin and leptin signal through their respective receptors that are expressed in multiple organs. For other adipocyte hormones, receptors are more promiscuous or remain to be identified. Furthermore, many of these hormones are also produced by other organs and tissues, which makes defining the endocrine contribution of adipose tissues a challenge. In this Review, we discuss the functional role of adipose tissue-derived endocrine hormones for metabolic adaptations to the environment and we highlight how these factors contribute to the development of cardiometabolic diseases. We also cover how this knowledge can be translated into human therapies. In addition, we discuss recent findings that emphasize the endocrine role of white versus thermogenic adipocytes in conditions of health and disease.
AB - In addition to their role in glucose and lipid metabolism, adipocytes respond differentially to physiological cues or metabolic stress by releasing endocrine factors that regulate diverse processes, such as energy expenditure, appetite control, glucose homeostasis, insulin sensitivity, inflammation and tissue repair. Both energy-storing white adipocytes and thermogenic brown and beige adipocytes secrete hormones, which can be peptides (adipokines), lipids (lipokines) and exosomal microRNAs. Some of these factors have defined targets; for example, adiponectin and leptin signal through their respective receptors that are expressed in multiple organs. For other adipocyte hormones, receptors are more promiscuous or remain to be identified. Furthermore, many of these hormones are also produced by other organs and tissues, which makes defining the endocrine contribution of adipose tissues a challenge. In this Review, we discuss the functional role of adipose tissue-derived endocrine hormones for metabolic adaptations to the environment and we highlight how these factors contribute to the development of cardiometabolic diseases. We also cover how this knowledge can be translated into human therapies. In addition, we discuss recent findings that emphasize the endocrine role of white versus thermogenic adipocytes in conditions of health and disease.
KW - Adipokines/metabolism
KW - Adipose Tissue/metabolism
KW - Animals
KW - Endocrine System Diseases/metabolism
KW - Health Status
KW - Heart Diseases/metabolism
KW - Hormones/metabolism
KW - Humans
KW - Metabolic Diseases/metabolism
U2 - 10.1038/s41574-019-0230-6
DO - 10.1038/s41574-019-0230-6
M3 - SCORING: Review article
C2 - 31296970
VL - 15
SP - 507
EP - 524
JO - NAT REV ENDOCRINOL
JF - NAT REV ENDOCRINOL
SN - 1759-5029
IS - 9
ER -
