The effects of treatment failure generalize across different routes of drug administration

Matthias Zunhammer; Markus Ploner; Charlotte Engelbrecht; Johanna Bock; Simon S Kessner; Ulrike Bingel

doi:10.1126/scitranslmed.aal2999

The effects of treatment failure generalize across different routes of drug administration

Standard

The effects of treatment failure generalize across different routes of drug administration. / Zunhammer, Matthias; Ploner, Markus; Engelbrecht, Charlotte; Bock, Johanna; Kessner, Simon S; Bingel, Ulrike.

In: SCI TRANSL MED, Vol. 9, No. 393, 07.06.2017.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zunhammer, M, Ploner, M, Engelbrecht, C, Bock, J, Kessner, SS & Bingel, U 2017, 'The effects of treatment failure generalize across different routes of drug administration', SCI TRANSL MED, vol. 9, no. 393. https://doi.org/10.1126/scitranslmed.aal2999

APA

Zunhammer, M., Ploner, M., Engelbrecht, C., Bock, J., Kessner, S. S., & Bingel, U. (2017). The effects of treatment failure generalize across different routes of drug administration. SCI TRANSL MED, 9(393). https://doi.org/10.1126/scitranslmed.aal2999

Vancouver

Zunhammer M, Ploner M, Engelbrecht C, Bock J, Kessner SS, Bingel U. The effects of treatment failure generalize across different routes of drug administration. SCI TRANSL MED. 2017 Jun 7;9(393). https://doi.org/10.1126/scitranslmed.aal2999

Bibtex

@article{c4bc39a2734b4ab682b9c59a6841c819,

title = "The effects of treatment failure generalize across different routes of drug administration",

abstract = "Failure of medical treatments can hamper responses to subsequent treatments. It has been suggested that changing the route of drug administration could reduce such negative carry-over effects, but direct evidence for this approach is lacking. We therefore investigated in 211 healthy volunteers whether changes in drug administration route reduce such carry-over effects. A positive or negative treatment history with topical analgesic treatments was induced experimentally in a mock clinical trial setting. Subsequently, a different inert drug was introduced via the same (topical) or another (oral) route of administration and its analgesic efficacy was tested. Changing the route of drug administration induced expectations of positive treatment effects in the subjects but did not actually counteract the negative carry-over effects on treatment efficacy. These findings indicate that learned carry-over effects generalize over time and across routes of drug administration-independent of conscious expectations. Other strategies are needed to prevent negative carry-over effects of treatment failure from influencing the results of subsequent treatment attempts.",

keywords = "Journal Article",

author = "Matthias Zunhammer and Markus Ploner and Charlotte Engelbrecht and Johanna Bock and Kessner, {Simon S} and Ulrike Bingel",

note = "Copyright {\textcopyright} 2017, American Association for the Advancement of Science.",

year = "2017",

month = jun,

day = "7",

doi = "10.1126/scitranslmed.aal2999",

language = "English",

volume = "9",

journal = "SCI TRANSL MED",

issn = "1946-6234",

publisher = "AMER ASSOC ADVANCEMENT SCIENCE",

number = "393",

}

RIS

TY - JOUR

T1 - The effects of treatment failure generalize across different routes of drug administration

AU - Zunhammer, Matthias

AU - Ploner, Markus

AU - Engelbrecht, Charlotte

AU - Bock, Johanna

AU - Kessner, Simon S

AU - Bingel, Ulrike

PY - 2017/6/7

Y1 - 2017/6/7

N2 - Failure of medical treatments can hamper responses to subsequent treatments. It has been suggested that changing the route of drug administration could reduce such negative carry-over effects, but direct evidence for this approach is lacking. We therefore investigated in 211 healthy volunteers whether changes in drug administration route reduce such carry-over effects. A positive or negative treatment history with topical analgesic treatments was induced experimentally in a mock clinical trial setting. Subsequently, a different inert drug was introduced via the same (topical) or another (oral) route of administration and its analgesic efficacy was tested. Changing the route of drug administration induced expectations of positive treatment effects in the subjects but did not actually counteract the negative carry-over effects on treatment efficacy. These findings indicate that learned carry-over effects generalize over time and across routes of drug administration-independent of conscious expectations. Other strategies are needed to prevent negative carry-over effects of treatment failure from influencing the results of subsequent treatment attempts.

AB - Failure of medical treatments can hamper responses to subsequent treatments. It has been suggested that changing the route of drug administration could reduce such negative carry-over effects, but direct evidence for this approach is lacking. We therefore investigated in 211 healthy volunteers whether changes in drug administration route reduce such carry-over effects. A positive or negative treatment history with topical analgesic treatments was induced experimentally in a mock clinical trial setting. Subsequently, a different inert drug was introduced via the same (topical) or another (oral) route of administration and its analgesic efficacy was tested. Changing the route of drug administration induced expectations of positive treatment effects in the subjects but did not actually counteract the negative carry-over effects on treatment efficacy. These findings indicate that learned carry-over effects generalize over time and across routes of drug administration-independent of conscious expectations. Other strategies are needed to prevent negative carry-over effects of treatment failure from influencing the results of subsequent treatment attempts.

KW - Journal Article

U2 - 10.1126/scitranslmed.aal2999

DO - 10.1126/scitranslmed.aal2999

M3 - SCORING: Journal article

C2 - 28592563

VL - 9

JO - SCI TRANSL MED

JF - SCI TRANSL MED

SN - 1946-6234

IS - 393

ER -