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The Effects of Pancreatic Microcirculatory Disturbances on Histopathologic Tissue Damage and the Outcome in Severe Acute Pancreatitis

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The Effects of Pancreatic Microcirculatory Disturbances on Histopathologic Tissue Damage and the Outcome in Severe Acute Pancreatitis. / Tomkötter, Lena; Erbes, Peter Johannes; Trepte, Constantin; Hinsch, Andrea; Dupree, Anna; Bockhorn, Maximilian; Mann, Oliver; Izbicki, Jakob R; Bachmann, Kai.

In: PANCREAS, Vol. 45, No. 2, 2016, p. 248-253.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tomkötter, L, Erbes, PJ, Trepte, C, Hinsch, A, Dupree, A, Bockhorn, M, Mann, O, Izbicki, JR & Bachmann, K 2016, 'The Effects of Pancreatic Microcirculatory Disturbances on Histopathologic Tissue Damage and the Outcome in Severe Acute Pancreatitis', PANCREAS, vol. 45, no. 2, pp. 248-253. https://doi.org/10.1097/MPA.0000000000000440

APA

Tomkötter, L., Erbes, P. J., Trepte, C., Hinsch, A., Dupree, A., Bockhorn, M., Mann, O., Izbicki, J. R., & Bachmann, K. (2016). The Effects of Pancreatic Microcirculatory Disturbances on Histopathologic Tissue Damage and the Outcome in Severe Acute Pancreatitis. PANCREAS, 45(2), 248-253. https://doi.org/10.1097/MPA.0000000000000440

Vancouver

Tomkötter L, Erbes PJ, Trepte C, Hinsch A, Dupree A, Bockhorn M et al. The Effects of Pancreatic Microcirculatory Disturbances on Histopathologic Tissue Damage and the Outcome in Severe Acute Pancreatitis. PANCREAS. 2016;45(2):248-253. https://doi.org/10.1097/MPA.0000000000000440

Bibtex

@article{2d3d89dcf1104b37b18a94f1f00cf5e6,
title = "The Effects of Pancreatic Microcirculatory Disturbances on Histopathologic Tissue Damage and the Outcome in Severe Acute Pancreatitis",
abstract = "OBJECTIVES: Severe acute pancreatitis is an inflammatory disease of the pancreas with a high morbidity and mortality. To date, no causal treatment is known. The aim of the present study was to analyze the impact of pancreatic microcirculatory disturbances in severe acute pancreatitis and to correlate the effects with histopathologic tissue damage and outcome.METHODS: Severe acute pancreatitis was induced in 129 pigs by injection of glycodeoxycholic acid into the pancreatic duct. Pancreatic microcirculation, pancreatic tissue oxygenation, histopathologic tissue damage, and survival were measured and analyzed.RESULTS: Our study demonstrates a strong correlation between pancreatic microcirculatory disturbances and histopathologic tissue damage (r = 0.728; P < 0.001). Furthermore, we showed a strong correlation between tissue oxygenation and the severity of the pancreatitis according to an established porcine pancreatitis score (r = 0.694; P < 0.001). In addition, disturbances of the pancreatic microcirculation were shown to be associated with an increased mortality rate in severe acute pancreatitis.CONCLUSIONS: We found that pancreatic microcirculatory disturbances have significant effects on histopathologic tissue damage and the outcome of severe acute pancreatitis. For a better survival of severe acute pancreatitis, the treatment should focus on an improvement of pancreatic microcirculation.",
author = "Lena Tomk{\"o}tter and Erbes, {Peter Johannes} and Constantin Trepte and Andrea Hinsch and Anna Dupree and Maximilian Bockhorn and Oliver Mann and Izbicki, {Jakob R} and Kai Bachmann",
year = "2016",
doi = "10.1097/MPA.0000000000000440",
language = "English",
volume = "45",
pages = "248--253",
journal = "PANCREAS",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

RIS

TY - JOUR

T1 - The Effects of Pancreatic Microcirculatory Disturbances on Histopathologic Tissue Damage and the Outcome in Severe Acute Pancreatitis

AU - Tomkötter, Lena

AU - Erbes, Peter Johannes

AU - Trepte, Constantin

AU - Hinsch, Andrea

AU - Dupree, Anna

AU - Bockhorn, Maximilian

AU - Mann, Oliver

AU - Izbicki, Jakob R

AU - Bachmann, Kai

PY - 2016

Y1 - 2016

N2 - OBJECTIVES: Severe acute pancreatitis is an inflammatory disease of the pancreas with a high morbidity and mortality. To date, no causal treatment is known. The aim of the present study was to analyze the impact of pancreatic microcirculatory disturbances in severe acute pancreatitis and to correlate the effects with histopathologic tissue damage and outcome.METHODS: Severe acute pancreatitis was induced in 129 pigs by injection of glycodeoxycholic acid into the pancreatic duct. Pancreatic microcirculation, pancreatic tissue oxygenation, histopathologic tissue damage, and survival were measured and analyzed.RESULTS: Our study demonstrates a strong correlation between pancreatic microcirculatory disturbances and histopathologic tissue damage (r = 0.728; P < 0.001). Furthermore, we showed a strong correlation between tissue oxygenation and the severity of the pancreatitis according to an established porcine pancreatitis score (r = 0.694; P < 0.001). In addition, disturbances of the pancreatic microcirculation were shown to be associated with an increased mortality rate in severe acute pancreatitis.CONCLUSIONS: We found that pancreatic microcirculatory disturbances have significant effects on histopathologic tissue damage and the outcome of severe acute pancreatitis. For a better survival of severe acute pancreatitis, the treatment should focus on an improvement of pancreatic microcirculation.

AB - OBJECTIVES: Severe acute pancreatitis is an inflammatory disease of the pancreas with a high morbidity and mortality. To date, no causal treatment is known. The aim of the present study was to analyze the impact of pancreatic microcirculatory disturbances in severe acute pancreatitis and to correlate the effects with histopathologic tissue damage and outcome.METHODS: Severe acute pancreatitis was induced in 129 pigs by injection of glycodeoxycholic acid into the pancreatic duct. Pancreatic microcirculation, pancreatic tissue oxygenation, histopathologic tissue damage, and survival were measured and analyzed.RESULTS: Our study demonstrates a strong correlation between pancreatic microcirculatory disturbances and histopathologic tissue damage (r = 0.728; P < 0.001). Furthermore, we showed a strong correlation between tissue oxygenation and the severity of the pancreatitis according to an established porcine pancreatitis score (r = 0.694; P < 0.001). In addition, disturbances of the pancreatic microcirculation were shown to be associated with an increased mortality rate in severe acute pancreatitis.CONCLUSIONS: We found that pancreatic microcirculatory disturbances have significant effects on histopathologic tissue damage and the outcome of severe acute pancreatitis. For a better survival of severe acute pancreatitis, the treatment should focus on an improvement of pancreatic microcirculation.

U2 - 10.1097/MPA.0000000000000440

DO - 10.1097/MPA.0000000000000440

M3 - SCORING: Journal article

C2 - 26646271

VL - 45

SP - 248

EP - 253

JO - PANCREAS

JF - PANCREAS

SN - 0885-3177

IS - 2

ER -