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The effect of subthalamic nucleus stimulation on autogenic inhibition in Parkinson disease

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The effect of subthalamic nucleus stimulation on autogenic inhibition in Parkinson disease. / Pötter, M; Illert, M; Wenzelburger, R; Deuschl, G; Volkmann, J.

In: NEUROLOGY, Vol. 63, No. 7, 12.10.2004, p. 1234-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Pötter, M, Illert, M, Wenzelburger, R, Deuschl, G & Volkmann, J 2004, 'The effect of subthalamic nucleus stimulation on autogenic inhibition in Parkinson disease', NEUROLOGY, vol. 63, no. 7, pp. 1234-9.

APA

Pötter, M., Illert, M., Wenzelburger, R., Deuschl, G., & Volkmann, J. (2004). The effect of subthalamic nucleus stimulation on autogenic inhibition in Parkinson disease. NEUROLOGY, 63(7), 1234-9.

Vancouver

Pötter M, Illert M, Wenzelburger R, Deuschl G, Volkmann J. The effect of subthalamic nucleus stimulation on autogenic inhibition in Parkinson disease. NEUROLOGY. 2004 Oct 12;63(7):1234-9.

Bibtex

@article{038bbe21fe2d4bd1965fb87bd778968c,
title = "The effect of subthalamic nucleus stimulation on autogenic inhibition in Parkinson disease",
abstract = "BACKGROUND: Recent animal experiments suggest an important role of descending input from basal ganglia to brainstem and via the reticulospinal tract (RST) to spinal cord in the genesis of motor symptoms in Parkinson disease (PD). In humans, a marker for RST activity is Ib mediated autogenic inhibition, which is reduced in PD patients. The authors investigated the effect of high frequency stimulation of the subthalamic nucleus (STN-HFS) on autogenic inhibition in PD.METHODS: In 10 controls and 10 PD patients with chronically implanted STN electrodes, the soleus H-reflex conditioned by gastrocnemius nerve stimulation (interstimulus interval 2 to 10 msec) was used to examine the effect of STN-HFS on the activity of Ib spinal interneurons.RESULTS: STN-HFS was able to restore the abnormally reduced autogenic inhibition. The H-reflex changes during STN-HFS significantly correlated with the clinical improvement of gait and posture.CONCLUSIONS: Observed changes in spinal autogenic inhibition may allow measurement of the contribution of subcortical routes to the STN-HFS induced motor benefit in PD.",
keywords = "Aged, Basal Ganglia, Electric Stimulation Therapy, Female, Humans, Interneurons, Male, Middle Aged, Neural Inhibition, Neural Pathways, Parkinson Disease, Reflex, Spinal Cord, Subthalamic Nucleus, Journal Article",
author = "M P{\"o}tter and M Illert and R Wenzelburger and G Deuschl and J Volkmann",
year = "2004",
month = oct,
day = "12",
language = "English",
volume = "63",
pages = "1234--9",
journal = "NEUROLOGY",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

RIS

TY - JOUR

T1 - The effect of subthalamic nucleus stimulation on autogenic inhibition in Parkinson disease

AU - Pötter, M

AU - Illert, M

AU - Wenzelburger, R

AU - Deuschl, G

AU - Volkmann, J

PY - 2004/10/12

Y1 - 2004/10/12

N2 - BACKGROUND: Recent animal experiments suggest an important role of descending input from basal ganglia to brainstem and via the reticulospinal tract (RST) to spinal cord in the genesis of motor symptoms in Parkinson disease (PD). In humans, a marker for RST activity is Ib mediated autogenic inhibition, which is reduced in PD patients. The authors investigated the effect of high frequency stimulation of the subthalamic nucleus (STN-HFS) on autogenic inhibition in PD.METHODS: In 10 controls and 10 PD patients with chronically implanted STN electrodes, the soleus H-reflex conditioned by gastrocnemius nerve stimulation (interstimulus interval 2 to 10 msec) was used to examine the effect of STN-HFS on the activity of Ib spinal interneurons.RESULTS: STN-HFS was able to restore the abnormally reduced autogenic inhibition. The H-reflex changes during STN-HFS significantly correlated with the clinical improvement of gait and posture.CONCLUSIONS: Observed changes in spinal autogenic inhibition may allow measurement of the contribution of subcortical routes to the STN-HFS induced motor benefit in PD.

AB - BACKGROUND: Recent animal experiments suggest an important role of descending input from basal ganglia to brainstem and via the reticulospinal tract (RST) to spinal cord in the genesis of motor symptoms in Parkinson disease (PD). In humans, a marker for RST activity is Ib mediated autogenic inhibition, which is reduced in PD patients. The authors investigated the effect of high frequency stimulation of the subthalamic nucleus (STN-HFS) on autogenic inhibition in PD.METHODS: In 10 controls and 10 PD patients with chronically implanted STN electrodes, the soleus H-reflex conditioned by gastrocnemius nerve stimulation (interstimulus interval 2 to 10 msec) was used to examine the effect of STN-HFS on the activity of Ib spinal interneurons.RESULTS: STN-HFS was able to restore the abnormally reduced autogenic inhibition. The H-reflex changes during STN-HFS significantly correlated with the clinical improvement of gait and posture.CONCLUSIONS: Observed changes in spinal autogenic inhibition may allow measurement of the contribution of subcortical routes to the STN-HFS induced motor benefit in PD.

KW - Aged

KW - Basal Ganglia

KW - Electric Stimulation Therapy

KW - Female

KW - Humans

KW - Interneurons

KW - Male

KW - Middle Aged

KW - Neural Inhibition

KW - Neural Pathways

KW - Parkinson Disease

KW - Reflex

KW - Spinal Cord

KW - Subthalamic Nucleus

KW - Journal Article

M3 - SCORING: Journal article

C2 - 15477544

VL - 63

SP - 1234

EP - 1239

JO - NEUROLOGY

JF - NEUROLOGY

SN - 0028-3878

IS - 7

ER -