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The Effect of Nicotine on HPA Axis Activity in Females is Modulated by the FKBP5 Genotype

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The Effect of Nicotine on HPA Axis Activity in Females is Modulated by the FKBP5 Genotype. / Koopmann, Anne; Bez, Jennifer; Lemenager, Tagrid; Hermann, Derik; Dinter, Christina; Reinhard, Iris; Schuster, Rilana; Wiedemann, Klaus; Winterer, Georg; Kiefer, Falk.

In: ANN HUM GENET, Vol. 80, No. 3, 05.2016, p. 154-61.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Koopmann, A, Bez, J, Lemenager, T, Hermann, D, Dinter, C, Reinhard, I, Schuster, R, Wiedemann, K, Winterer, G & Kiefer, F 2016, 'The Effect of Nicotine on HPA Axis Activity in Females is Modulated by the FKBP5 Genotype', ANN HUM GENET, vol. 80, no. 3, pp. 154-61. https://doi.org/10.1111/ahg.12153

APA

Koopmann, A., Bez, J., Lemenager, T., Hermann, D., Dinter, C., Reinhard, I., Schuster, R., Wiedemann, K., Winterer, G., & Kiefer, F. (2016). The Effect of Nicotine on HPA Axis Activity in Females is Modulated by the FKBP5 Genotype. ANN HUM GENET, 80(3), 154-61. https://doi.org/10.1111/ahg.12153

Vancouver

Koopmann A, Bez J, Lemenager T, Hermann D, Dinter C, Reinhard I et al. The Effect of Nicotine on HPA Axis Activity in Females is Modulated by the FKBP5 Genotype. ANN HUM GENET. 2016 May;80(3):154-61. https://doi.org/10.1111/ahg.12153

Bibtex

@article{89d44a809add46e7a7ad93ab9fb15295,
title = "The Effect of Nicotine on HPA Axis Activity in Females is Modulated by the FKBP5 Genotype",
abstract = "Tobacco smoking modulates activity in the hypothalamic-pituitary-adrenal (HPA) axis and is used to cope with stress, especially by females. The single nucleotide polymorphism (SNP) rs1360780, linked to FK506-binding protein 51 (FKBP5), has been shown to affect HPA axis functioning, and has thus been suggested as a promising candidate for indicating vulnerability to stress-related disorders. The aim of this study was to investigate the interaction between nicotine consumption and rs1360780 on cortisol plasma levels in females. A total of 296 female smokers (assessed by the Fagerstr{\"o}m Test for Nicotine Dependence; FTND) were genotyped for the SNP rs1360780. We measured participants' cortisol plasma concentration in blood plasma collected 3 h after standardized tobacco smoking exposure. In the 36 TT-homozygotes, we found a significant negative correlation between the FTND sum score and cortisol plasma concentrations. Using linear regression analysis, we found that the FTND sum score accounted for 12.4% of the variance of cortisol plasma levels. This association was not detected in C-allele carriers. Our results suggest that nicotine is an important confounder in the modulation of HPA axis activity by FKBP5. In light of these findings, future studies on FKBP5 should seek to include data on nicotine consumption as a covariate.",
keywords = "Adult, Alleles, Female, Genotype, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Nicotine, Pituitary-Adrenal System, Polymorphism, Single Nucleotide, Smoking, Stress, Psychological, Tacrolimus Binding Proteins, Journal Article, Research Support, Non-U.S. Gov't",
author = "Anne Koopmann and Jennifer Bez and Tagrid Lemenager and Derik Hermann and Christina Dinter and Iris Reinhard and Rilana Schuster and Klaus Wiedemann and Georg Winterer and Falk Kiefer",
note = "{\textcopyright} 2016 John Wiley & Sons Ltd/University College London.",
year = "2016",
month = may,
doi = "10.1111/ahg.12153",
language = "English",
volume = "80",
pages = "154--61",
journal = "ANN HUM GENET",
issn = "0003-4800",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - The Effect of Nicotine on HPA Axis Activity in Females is Modulated by the FKBP5 Genotype

AU - Koopmann, Anne

AU - Bez, Jennifer

AU - Lemenager, Tagrid

AU - Hermann, Derik

AU - Dinter, Christina

AU - Reinhard, Iris

AU - Schuster, Rilana

AU - Wiedemann, Klaus

AU - Winterer, Georg

AU - Kiefer, Falk

N1 - © 2016 John Wiley & Sons Ltd/University College London.

PY - 2016/5

Y1 - 2016/5

N2 - Tobacco smoking modulates activity in the hypothalamic-pituitary-adrenal (HPA) axis and is used to cope with stress, especially by females. The single nucleotide polymorphism (SNP) rs1360780, linked to FK506-binding protein 51 (FKBP5), has been shown to affect HPA axis functioning, and has thus been suggested as a promising candidate for indicating vulnerability to stress-related disorders. The aim of this study was to investigate the interaction between nicotine consumption and rs1360780 on cortisol plasma levels in females. A total of 296 female smokers (assessed by the Fagerström Test for Nicotine Dependence; FTND) were genotyped for the SNP rs1360780. We measured participants' cortisol plasma concentration in blood plasma collected 3 h after standardized tobacco smoking exposure. In the 36 TT-homozygotes, we found a significant negative correlation between the FTND sum score and cortisol plasma concentrations. Using linear regression analysis, we found that the FTND sum score accounted for 12.4% of the variance of cortisol plasma levels. This association was not detected in C-allele carriers. Our results suggest that nicotine is an important confounder in the modulation of HPA axis activity by FKBP5. In light of these findings, future studies on FKBP5 should seek to include data on nicotine consumption as a covariate.

AB - Tobacco smoking modulates activity in the hypothalamic-pituitary-adrenal (HPA) axis and is used to cope with stress, especially by females. The single nucleotide polymorphism (SNP) rs1360780, linked to FK506-binding protein 51 (FKBP5), has been shown to affect HPA axis functioning, and has thus been suggested as a promising candidate for indicating vulnerability to stress-related disorders. The aim of this study was to investigate the interaction between nicotine consumption and rs1360780 on cortisol plasma levels in females. A total of 296 female smokers (assessed by the Fagerström Test for Nicotine Dependence; FTND) were genotyped for the SNP rs1360780. We measured participants' cortisol plasma concentration in blood plasma collected 3 h after standardized tobacco smoking exposure. In the 36 TT-homozygotes, we found a significant negative correlation between the FTND sum score and cortisol plasma concentrations. Using linear regression analysis, we found that the FTND sum score accounted for 12.4% of the variance of cortisol plasma levels. This association was not detected in C-allele carriers. Our results suggest that nicotine is an important confounder in the modulation of HPA axis activity by FKBP5. In light of these findings, future studies on FKBP5 should seek to include data on nicotine consumption as a covariate.

KW - Adult

KW - Alleles

KW - Female

KW - Genotype

KW - Humans

KW - Hydrocortisone

KW - Hypothalamo-Hypophyseal System

KW - Nicotine

KW - Pituitary-Adrenal System

KW - Polymorphism, Single Nucleotide

KW - Smoking

KW - Stress, Psychological

KW - Tacrolimus Binding Proteins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1111/ahg.12153

DO - 10.1111/ahg.12153

M3 - SCORING: Journal article

C2 - 27062383

VL - 80

SP - 154

EP - 161

JO - ANN HUM GENET

JF - ANN HUM GENET

SN - 0003-4800

IS - 3

ER -