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The effect of intraventricular thrombolysis in combination with low-frequency head motion after severe subarachnoid hemorrhage

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The effect of intraventricular thrombolysis in combination with low-frequency head motion after severe subarachnoid hemorrhage : interim analysis of safety, clot clearance rate and delayed cerebral ischemia. / Eicker, Sven O; Beseoglu, Kerim; Etminan, Nima; Perrin, Jason; Taskin, Arzu; Steiger, Hans-Jakob; Hänggi, Daniel.

In: ACTA NEUROCHIR SUPPL, Vol. 114, 2012, p. 323-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Eicker, SO, Beseoglu, K, Etminan, N, Perrin, J, Taskin, A, Steiger, H-J & Hänggi, D 2012, 'The effect of intraventricular thrombolysis in combination with low-frequency head motion after severe subarachnoid hemorrhage: interim analysis of safety, clot clearance rate and delayed cerebral ischemia', ACTA NEUROCHIR SUPPL, vol. 114, pp. 323-8. https://doi.org/10.1007/978-3-7091-0956-4_62

APA

Eicker, S. O., Beseoglu, K., Etminan, N., Perrin, J., Taskin, A., Steiger, H-J., & Hänggi, D. (2012). The effect of intraventricular thrombolysis in combination with low-frequency head motion after severe subarachnoid hemorrhage: interim analysis of safety, clot clearance rate and delayed cerebral ischemia. ACTA NEUROCHIR SUPPL, 114, 323-8. https://doi.org/10.1007/978-3-7091-0956-4_62

Vancouver

Eicker SO, Beseoglu K, Etminan N, Perrin J, Taskin A, Steiger H-J et al. The effect of intraventricular thrombolysis in combination with low-frequency head motion after severe subarachnoid hemorrhage: interim analysis of safety, clot clearance rate and delayed cerebral ischemia. ACTA NEUROCHIR SUPPL. 2012;114:323-8. https://doi.org/10.1007/978-3-7091-0956-4_62

Bibtex

@article{a692794251e9448dbc7fef4937bab064,
title = "The effect of intraventricular thrombolysis in combination with low-frequency head motion after severe subarachnoid hemorrhage: interim analysis of safety, clot clearance rate and delayed cerebral ischemia",
abstract = "OBJECTIVE: The current clinical prospective randomized phase II study was initiated in order to analyze the effect of enhanced washout by discontinuous intraventricular thrombolysis in combination with low-frequency head-motion therapy on side effects, clot clearance rate, cerebral vasospasm and clinical outcome after severe subarachnoid hemorrhage (SAH).METHODS: Data from 40 adult patients with aneurysmal SAH were included in this interim analysis. Patients randomized to the study group achieved additional intraventricular application of rt-PA (Actilyse({\textregistered})) bolus 5 mg every 12 h and lateral rotational therapy (RotoRest({\textregistered})). Clot clearance rate was evaluated based on computed tomography (CT). Delayed cerebral ischemia (DCI) and early clinical outcome of patients were determined.RESULTS: No severe side effects due to the combined therapy were documented. The clot clearance rate was significantly higher in the study group than in the control group regarding the cranial and basal CT slices (p = 0.003 cranial slices and p = 0.037 basal slices). Delayed ischemic neurological deficits (DIND) were increased in the control group (p = 0.016).CONCLUSION: The present study demonstrates that a combination of intraventricular thrombolysis and lateral rotational therapy is not associated with a higher complication rate. Furthermore, the therapy leads to a significant acceleration of the clot clearance rate.",
keywords = "Adult, Aged, Blood Flow Velocity, Brain Ischemia, Chi-Square Distribution, Double-Blind Method, Female, Follow-Up Studies, Glasgow Coma Scale, Humans, Male, Middle Aged, Motion Therapy, Continuous Passive, Prospective Studies, Subarachnoid Hemorrhage, Thrombolytic Therapy, Tomography, X-Ray Computed, Ultrasonography, Doppler, Transcranial, Vasospasm, Intracranial",
author = "Eicker, {Sven O} and Kerim Beseoglu and Nima Etminan and Jason Perrin and Arzu Taskin and Hans-Jakob Steiger and Daniel H{\"a}nggi",
year = "2012",
doi = "10.1007/978-3-7091-0956-4_62",
language = "English",
volume = "114",
pages = "323--8",
journal = "ACTA NEUROCHIR SUPPL",
issn = "0065-1419",
publisher = "Springer Wien",

}

RIS

TY - JOUR

T1 - The effect of intraventricular thrombolysis in combination with low-frequency head motion after severe subarachnoid hemorrhage

T2 - interim analysis of safety, clot clearance rate and delayed cerebral ischemia

AU - Eicker, Sven O

AU - Beseoglu, Kerim

AU - Etminan, Nima

AU - Perrin, Jason

AU - Taskin, Arzu

AU - Steiger, Hans-Jakob

AU - Hänggi, Daniel

PY - 2012

Y1 - 2012

N2 - OBJECTIVE: The current clinical prospective randomized phase II study was initiated in order to analyze the effect of enhanced washout by discontinuous intraventricular thrombolysis in combination with low-frequency head-motion therapy on side effects, clot clearance rate, cerebral vasospasm and clinical outcome after severe subarachnoid hemorrhage (SAH).METHODS: Data from 40 adult patients with aneurysmal SAH were included in this interim analysis. Patients randomized to the study group achieved additional intraventricular application of rt-PA (Actilyse(®)) bolus 5 mg every 12 h and lateral rotational therapy (RotoRest(®)). Clot clearance rate was evaluated based on computed tomography (CT). Delayed cerebral ischemia (DCI) and early clinical outcome of patients were determined.RESULTS: No severe side effects due to the combined therapy were documented. The clot clearance rate was significantly higher in the study group than in the control group regarding the cranial and basal CT slices (p = 0.003 cranial slices and p = 0.037 basal slices). Delayed ischemic neurological deficits (DIND) were increased in the control group (p = 0.016).CONCLUSION: The present study demonstrates that a combination of intraventricular thrombolysis and lateral rotational therapy is not associated with a higher complication rate. Furthermore, the therapy leads to a significant acceleration of the clot clearance rate.

AB - OBJECTIVE: The current clinical prospective randomized phase II study was initiated in order to analyze the effect of enhanced washout by discontinuous intraventricular thrombolysis in combination with low-frequency head-motion therapy on side effects, clot clearance rate, cerebral vasospasm and clinical outcome after severe subarachnoid hemorrhage (SAH).METHODS: Data from 40 adult patients with aneurysmal SAH were included in this interim analysis. Patients randomized to the study group achieved additional intraventricular application of rt-PA (Actilyse(®)) bolus 5 mg every 12 h and lateral rotational therapy (RotoRest(®)). Clot clearance rate was evaluated based on computed tomography (CT). Delayed cerebral ischemia (DCI) and early clinical outcome of patients were determined.RESULTS: No severe side effects due to the combined therapy were documented. The clot clearance rate was significantly higher in the study group than in the control group regarding the cranial and basal CT slices (p = 0.003 cranial slices and p = 0.037 basal slices). Delayed ischemic neurological deficits (DIND) were increased in the control group (p = 0.016).CONCLUSION: The present study demonstrates that a combination of intraventricular thrombolysis and lateral rotational therapy is not associated with a higher complication rate. Furthermore, the therapy leads to a significant acceleration of the clot clearance rate.

KW - Adult

KW - Aged

KW - Blood Flow Velocity

KW - Brain Ischemia

KW - Chi-Square Distribution

KW - Double-Blind Method

KW - Female

KW - Follow-Up Studies

KW - Glasgow Coma Scale

KW - Humans

KW - Male

KW - Middle Aged

KW - Motion Therapy, Continuous Passive

KW - Prospective Studies

KW - Subarachnoid Hemorrhage

KW - Thrombolytic Therapy

KW - Tomography, X-Ray Computed

KW - Ultrasonography, Doppler, Transcranial

KW - Vasospasm, Intracranial

U2 - 10.1007/978-3-7091-0956-4_62

DO - 10.1007/978-3-7091-0956-4_62

M3 - SCORING: Journal article

C2 - 22327716

VL - 114

SP - 323

EP - 328

JO - ACTA NEUROCHIR SUPPL

JF - ACTA NEUROCHIR SUPPL

SN - 0065-1419

ER -