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The effect of intra- and postoperative allogenic blood transfusion on patients' survival undergoing radical cystectomy for urothelial carcinoma of the bladder

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The effect of intra- and postoperative allogenic blood transfusion on patients' survival undergoing radical cystectomy for urothelial carcinoma of the bladder. / Gierth, M; Aziz, A; Fritsche, H M; Burger, M; Otto, W; Zeman, F; Pawlik, M T; Hansen, E; May, M; Denzinger, S.

In: WORLD J UROL, Vol. 32, No. 6, 12.2014, p. 1447-53.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gierth, M, Aziz, A, Fritsche, HM, Burger, M, Otto, W, Zeman, F, Pawlik, MT, Hansen, E, May, M & Denzinger, S 2014, 'The effect of intra- and postoperative allogenic blood transfusion on patients' survival undergoing radical cystectomy for urothelial carcinoma of the bladder', WORLD J UROL, vol. 32, no. 6, pp. 1447-53. https://doi.org/10.1007/s00345-014-1257-x

APA

Gierth, M., Aziz, A., Fritsche, H. M., Burger, M., Otto, W., Zeman, F., Pawlik, M. T., Hansen, E., May, M., & Denzinger, S. (2014). The effect of intra- and postoperative allogenic blood transfusion on patients' survival undergoing radical cystectomy for urothelial carcinoma of the bladder. WORLD J UROL, 32(6), 1447-53. https://doi.org/10.1007/s00345-014-1257-x

Vancouver

Gierth M, Aziz A, Fritsche HM, Burger M, Otto W, Zeman F et al. The effect of intra- and postoperative allogenic blood transfusion on patients' survival undergoing radical cystectomy for urothelial carcinoma of the bladder. WORLD J UROL. 2014 Dec;32(6):1447-53. https://doi.org/10.1007/s00345-014-1257-x

Bibtex

@article{b6262d87749b426e85d41f1731234e5b,
title = "The effect of intra- and postoperative allogenic blood transfusion on patients' survival undergoing radical cystectomy for urothelial carcinoma of the bladder",
abstract = "PURPOSE: Radical cystectomy (RC) can be associated with significant blood loss. Allogenic blood transfusion (ABT) may alter disease outcome because of a theoretical immunomodulatory effect. We evaluated the effects of ABT on overall survival (OS) and progression-free survival (PFS) of patients undergoing RC for urothelial carcinoma of the bladder (UCB).MATERIALS AND METHODS: This is a retrospective single-center study of 350 consecutive patients of a university health center with a median follow-up of 70.1 month. All patients underwent RC and pelvic lymph node dissection. The effect of ABT on OS and PFS was analyzed using univariable and multivariable Cox proportional hazards models.RESULTS: The overall ABT rate was 63 % (n = 219), with intraoperative blood transfusion and postoperative blood transfusion being performed in 183 patients (52 %) and 99 patients (28 %), respectively. Preoperative anemia was detected in 156 patients (45 %) with median estimated blood loss of 800 ml (IQR: 500-1,200). ABT was associated with significant decrease of OS and PFS in multivariable analyses (p < 0.001), whereas patients' prognosis worsened the more packed red blood cells (PRBC) were transfused (p < 0.001). The study is limited in part due to its retrospective design.CONCLUSIONS: We found that ABT and the number of PRBC transfused are associated with poor prognosis for UCB patients undergoing RC, whereas preoperative anemia had no influence on survival. This emphasizes the importance of surgeon's awareness for a strict indication for ABT. A prospective study will be necessary to evaluate the independent risks associated with ABT during surgical treatments.",
keywords = "Aged, Anemia, Blood Transfusion, Carcinoma, Cystectomy, Disease-Free Survival, Female, Humans, Intraoperative Care, Male, Middle Aged, Postoperative Care, Retrospective Studies, Survival Rate, Treatment Outcome, Urinary Bladder Neoplasms, Urothelium, Journal Article",
author = "M Gierth and A Aziz and Fritsche, {H M} and M Burger and W Otto and F Zeman and Pawlik, {M T} and E Hansen and M May and S Denzinger",
year = "2014",
month = dec,
doi = "10.1007/s00345-014-1257-x",
language = "English",
volume = "32",
pages = "1447--53",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - The effect of intra- and postoperative allogenic blood transfusion on patients' survival undergoing radical cystectomy for urothelial carcinoma of the bladder

AU - Gierth, M

AU - Aziz, A

AU - Fritsche, H M

AU - Burger, M

AU - Otto, W

AU - Zeman, F

AU - Pawlik, M T

AU - Hansen, E

AU - May, M

AU - Denzinger, S

PY - 2014/12

Y1 - 2014/12

N2 - PURPOSE: Radical cystectomy (RC) can be associated with significant blood loss. Allogenic blood transfusion (ABT) may alter disease outcome because of a theoretical immunomodulatory effect. We evaluated the effects of ABT on overall survival (OS) and progression-free survival (PFS) of patients undergoing RC for urothelial carcinoma of the bladder (UCB).MATERIALS AND METHODS: This is a retrospective single-center study of 350 consecutive patients of a university health center with a median follow-up of 70.1 month. All patients underwent RC and pelvic lymph node dissection. The effect of ABT on OS and PFS was analyzed using univariable and multivariable Cox proportional hazards models.RESULTS: The overall ABT rate was 63 % (n = 219), with intraoperative blood transfusion and postoperative blood transfusion being performed in 183 patients (52 %) and 99 patients (28 %), respectively. Preoperative anemia was detected in 156 patients (45 %) with median estimated blood loss of 800 ml (IQR: 500-1,200). ABT was associated with significant decrease of OS and PFS in multivariable analyses (p < 0.001), whereas patients' prognosis worsened the more packed red blood cells (PRBC) were transfused (p < 0.001). The study is limited in part due to its retrospective design.CONCLUSIONS: We found that ABT and the number of PRBC transfused are associated with poor prognosis for UCB patients undergoing RC, whereas preoperative anemia had no influence on survival. This emphasizes the importance of surgeon's awareness for a strict indication for ABT. A prospective study will be necessary to evaluate the independent risks associated with ABT during surgical treatments.

AB - PURPOSE: Radical cystectomy (RC) can be associated with significant blood loss. Allogenic blood transfusion (ABT) may alter disease outcome because of a theoretical immunomodulatory effect. We evaluated the effects of ABT on overall survival (OS) and progression-free survival (PFS) of patients undergoing RC for urothelial carcinoma of the bladder (UCB).MATERIALS AND METHODS: This is a retrospective single-center study of 350 consecutive patients of a university health center with a median follow-up of 70.1 month. All patients underwent RC and pelvic lymph node dissection. The effect of ABT on OS and PFS was analyzed using univariable and multivariable Cox proportional hazards models.RESULTS: The overall ABT rate was 63 % (n = 219), with intraoperative blood transfusion and postoperative blood transfusion being performed in 183 patients (52 %) and 99 patients (28 %), respectively. Preoperative anemia was detected in 156 patients (45 %) with median estimated blood loss of 800 ml (IQR: 500-1,200). ABT was associated with significant decrease of OS and PFS in multivariable analyses (p < 0.001), whereas patients' prognosis worsened the more packed red blood cells (PRBC) were transfused (p < 0.001). The study is limited in part due to its retrospective design.CONCLUSIONS: We found that ABT and the number of PRBC transfused are associated with poor prognosis for UCB patients undergoing RC, whereas preoperative anemia had no influence on survival. This emphasizes the importance of surgeon's awareness for a strict indication for ABT. A prospective study will be necessary to evaluate the independent risks associated with ABT during surgical treatments.

KW - Aged

KW - Anemia

KW - Blood Transfusion

KW - Carcinoma

KW - Cystectomy

KW - Disease-Free Survival

KW - Female

KW - Humans

KW - Intraoperative Care

KW - Male

KW - Middle Aged

KW - Postoperative Care

KW - Retrospective Studies

KW - Survival Rate

KW - Treatment Outcome

KW - Urinary Bladder Neoplasms

KW - Urothelium

KW - Journal Article

U2 - 10.1007/s00345-014-1257-x

DO - 10.1007/s00345-014-1257-x

M3 - SCORING: Journal article

C2 - 24510120

VL - 32

SP - 1447

EP - 1453

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 6

ER -