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The effect of family history on screening procedures and prognosis in breast cancer patients - Results of a large population-based case-control study

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The effect of family history on screening procedures and prognosis in breast cancer patients - Results of a large population-based case-control study. / Seiffert, Katharina; Thoene, Kathrin; Eulenburg, Christine Zu; Behrens, Sabine; Schmalfeldt, Barbara; Becher, Heiko; Chang-Claude, Jenny; Witzel, Isabell.

In: BREAST, Vol. 55, 02.2021, p. 98-104.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Seiffert, K, Thoene, K, Eulenburg, CZ, Behrens, S, Schmalfeldt, B, Becher, H, Chang-Claude, J & Witzel, I 2021, 'The effect of family history on screening procedures and prognosis in breast cancer patients - Results of a large population-based case-control study', BREAST, vol. 55, pp. 98-104. https://doi.org/10.1016/j.breast.2020.12.008

APA

Seiffert, K., Thoene, K., Eulenburg, C. Z., Behrens, S., Schmalfeldt, B., Becher, H., Chang-Claude, J., & Witzel, I. (2021). The effect of family history on screening procedures and prognosis in breast cancer patients - Results of a large population-based case-control study. BREAST, 55, 98-104. https://doi.org/10.1016/j.breast.2020.12.008

Vancouver

Seiffert K, Thoene K, Eulenburg CZ, Behrens S, Schmalfeldt B, Becher H et al. The effect of family history on screening procedures and prognosis in breast cancer patients - Results of a large population-based case-control study. BREAST. 2021 Feb;55:98-104. https://doi.org/10.1016/j.breast.2020.12.008

Bibtex

@article{d3eee173257841ac825de1b8bb49a2d9,
title = "The effect of family history on screening procedures and prognosis in breast cancer patients - Results of a large population-based case-control study",
abstract = "BACKGROUND: The potential benefit of additional breast cancer screening examinations in moderate risk patients (patients with a history of breast cancer in one or two family members) remains unclear.METHODS: A large population-based case-control study on breast cancer in postmenopausal women in Germany recruited 2002-2005 (3813 cases and 7341 age-matched controls) was used to assess the association of family history with breast cancer risk. Analysis of family history, participation in screening procedures, and tumor size regarding prognosis in patients was based on follow-up data until 2015.RESULTS: A first degree family history of breast cancer was associated with higher breast cancer risk (OR 1.39, p < 0.001). Patients with a first degree family history of breast cancer were more likely to have had >10 mammograms (MG) (42.7% vs. 24.9%, p < 0.001) and showed a higher rate of imaging-detected tumors (MG or ultrasound) (45.8% vs. 31.9%, p < 0.001). A smaller tumor size at initial diagnosis (below 2 cm) was more likely in patients with a positive family history (OR 1.45, p < 0.001) and a higher number of MG (≥10 MG: OR 2.29). After accounting for tumor characteristics, mammogram regularity (HR 0.72, p < 0.001) and imaging-assisted tumor detection (HR 0.66, p < 0.001) were associated with better overall survival but not with a positive family history.DISCUSSION: Patients with a positive family history had a higher rate of imaging detected tumors with smaller size at initial diagnosis compared to patients without affected family members. Screening was associated with improved survival after a breast cancer diagnosis, irrespective of a positive family history.",
author = "Katharina Seiffert and Kathrin Thoene and Eulenburg, {Christine Zu} and Sabine Behrens and Barbara Schmalfeldt and Heiko Becher and Jenny Chang-Claude and Isabell Witzel",
note = "Copyright {\textcopyright} 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.",
year = "2021",
month = feb,
doi = "10.1016/j.breast.2020.12.008",
language = "English",
volume = "55",
pages = "98--104",
journal = "BREAST",
issn = "0960-9776",
publisher = "Churchill Livingstone",

}

RIS

TY - JOUR

T1 - The effect of family history on screening procedures and prognosis in breast cancer patients - Results of a large population-based case-control study

AU - Seiffert, Katharina

AU - Thoene, Kathrin

AU - Eulenburg, Christine Zu

AU - Behrens, Sabine

AU - Schmalfeldt, Barbara

AU - Becher, Heiko

AU - Chang-Claude, Jenny

AU - Witzel, Isabell

N1 - Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2021/2

Y1 - 2021/2

N2 - BACKGROUND: The potential benefit of additional breast cancer screening examinations in moderate risk patients (patients with a history of breast cancer in one or two family members) remains unclear.METHODS: A large population-based case-control study on breast cancer in postmenopausal women in Germany recruited 2002-2005 (3813 cases and 7341 age-matched controls) was used to assess the association of family history with breast cancer risk. Analysis of family history, participation in screening procedures, and tumor size regarding prognosis in patients was based on follow-up data until 2015.RESULTS: A first degree family history of breast cancer was associated with higher breast cancer risk (OR 1.39, p < 0.001). Patients with a first degree family history of breast cancer were more likely to have had >10 mammograms (MG) (42.7% vs. 24.9%, p < 0.001) and showed a higher rate of imaging-detected tumors (MG or ultrasound) (45.8% vs. 31.9%, p < 0.001). A smaller tumor size at initial diagnosis (below 2 cm) was more likely in patients with a positive family history (OR 1.45, p < 0.001) and a higher number of MG (≥10 MG: OR 2.29). After accounting for tumor characteristics, mammogram regularity (HR 0.72, p < 0.001) and imaging-assisted tumor detection (HR 0.66, p < 0.001) were associated with better overall survival but not with a positive family history.DISCUSSION: Patients with a positive family history had a higher rate of imaging detected tumors with smaller size at initial diagnosis compared to patients without affected family members. Screening was associated with improved survival after a breast cancer diagnosis, irrespective of a positive family history.

AB - BACKGROUND: The potential benefit of additional breast cancer screening examinations in moderate risk patients (patients with a history of breast cancer in one or two family members) remains unclear.METHODS: A large population-based case-control study on breast cancer in postmenopausal women in Germany recruited 2002-2005 (3813 cases and 7341 age-matched controls) was used to assess the association of family history with breast cancer risk. Analysis of family history, participation in screening procedures, and tumor size regarding prognosis in patients was based on follow-up data until 2015.RESULTS: A first degree family history of breast cancer was associated with higher breast cancer risk (OR 1.39, p < 0.001). Patients with a first degree family history of breast cancer were more likely to have had >10 mammograms (MG) (42.7% vs. 24.9%, p < 0.001) and showed a higher rate of imaging-detected tumors (MG or ultrasound) (45.8% vs. 31.9%, p < 0.001). A smaller tumor size at initial diagnosis (below 2 cm) was more likely in patients with a positive family history (OR 1.45, p < 0.001) and a higher number of MG (≥10 MG: OR 2.29). After accounting for tumor characteristics, mammogram regularity (HR 0.72, p < 0.001) and imaging-assisted tumor detection (HR 0.66, p < 0.001) were associated with better overall survival but not with a positive family history.DISCUSSION: Patients with a positive family history had a higher rate of imaging detected tumors with smaller size at initial diagnosis compared to patients without affected family members. Screening was associated with improved survival after a breast cancer diagnosis, irrespective of a positive family history.

U2 - 10.1016/j.breast.2020.12.008

DO - 10.1016/j.breast.2020.12.008

M3 - SCORING: Journal article

C2 - 33395600

VL - 55

SP - 98

EP - 104

JO - BREAST

JF - BREAST

SN - 0960-9776

ER -