Research ExplorerPublicationsThe effect of BMI on clinicopathologic and functional outcom...

The effect of BMI on clinicopathologic and functional outcomes after open radical prostatectomy

Standard

The effect of BMI on clinicopathologic and functional outcomes after open radical prostatectomy. / Mandel, Philipp; Kretschmer, Alexander; Chandrasekar, Thenappan; Nguyen, Hao G; Buchner, Alexander; Stief, Christian G; Tilki, Derya.

In: UROL ONCOL-SEMIN ORI, Vol. 32, No. 3, 04.2014, p. 297-302.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mandel, P, Kretschmer, A, Chandrasekar, T, Nguyen, HG, Buchner, A, Stief, CG & Tilki, D 2014, 'The effect of BMI on clinicopathologic and functional outcomes after open radical prostatectomy', UROL ONCOL-SEMIN ORI, vol. 32, no. 3, pp. 297-302. https://doi.org/10.1016/j.urolonc.2013.09.005

APA

Mandel, P., Kretschmer, A., Chandrasekar, T., Nguyen, H. G., Buchner, A., Stief, C. G., & Tilki, D. (2014). The effect of BMI on clinicopathologic and functional outcomes after open radical prostatectomy. UROL ONCOL-SEMIN ORI, 32(3), 297-302. https://doi.org/10.1016/j.urolonc.2013.09.005

Vancouver

Mandel P, Kretschmer A, Chandrasekar T, Nguyen HG, Buchner A, Stief CG et al. The effect of BMI on clinicopathologic and functional outcomes after open radical prostatectomy. UROL ONCOL-SEMIN ORI. 2014 Apr;32(3):297-302. https://doi.org/10.1016/j.urolonc.2013.09.005

Bibtex

@article{9ad9f80ef51a44eda4f3fa6a31553148,
title = "The effect of BMI on clinicopathologic and functional outcomes after open radical prostatectomy",
abstract = "OBJECTIVES: To analyze the effect of body mass index (BMI) on pathologic and functional outcomes after open radical retropubic prostatectomy.PATIENTS AND METHODS: We retrospectively analyzed 2,471 patients who underwent RP. Clinicopathologic and patient characteristics were compared with respect to patients' BMI (normal weight: BMI < 25 kg/m(2) [n = 795], overweight: BMI ≥ 25 kg/m(2) and < 30 kg/m(2) [n = 1305], and obese: BMI ≥ 30 kg/m(2) [n = 371]). Multivariable logistic and linear regression models were used to quantify the effect of BMI on pathologic and functional outcomes.RESULTS: Compared with normal weight patients, overweight and obese patients demonstrated higher pathologic Gleason grade and higher pathologic T stage, without any difference in preoperative prostate-specific antigen levels. Overweight and obese men were less likely to have a negative surgical margin (odds ratio (OR) 0.74 [confidence interval (CI) 0.65-0.84, P<0.001] for overweight men and OR 0.66 [CI 0.49-0.89, P<0.01] for obese men) and had a lower rate of postoperative erectile function (OR 0.60 [CI 0.48-0.76, P<0.001] for overweight patients and OR 0.34 [CI 0.27-0.44, P<0.001] for obese patients). Moreover, duration of surgery and intraoperative blood loss increased significantly with an increase in BMI. When using BMI as a continuous variable, the same trends were demonstrated. However, a lower rate of continence was not evident for overweight or obese men.CONCLUSIONS: In contrast to many other studies, in this cohort of patients with prostate cancer, BMI was an independent risk factor for most analyzed pathologic and functional outcomes after radical prostatectomy, including negative surgical margin, potency, duration of surgery, and intraoperative blood loss.",
keywords = "Aged, Body Mass Index, Humans, Male, Middle Aged, Obesity, Overweight, Prostatectomy, Prostatic Neoplasms, Recovery of Function, Retrospective Studies, Risk Factors, Treatment Outcome, Journal Article",
author = "Philipp Mandel and Alexander Kretschmer and Thenappan Chandrasekar and Nguyen, {Hao G} and Alexander Buchner and Stief, {Christian G} and Derya Tilki",
note = "{\textcopyright} 2013 Published by Elsevier Inc.",
year = "2014",
month = apr,
doi = "10.1016/j.urolonc.2013.09.005",
language = "English",
volume = "32",
pages = "297--302",
journal = "UROL ONCOL-SEMIN ORI",
issn = "1078-1439",
publisher = "Elsevier Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - The effect of BMI on clinicopathologic and functional outcomes after open radical prostatectomy

AU - Mandel, Philipp

AU - Kretschmer, Alexander

AU - Chandrasekar, Thenappan

AU - Nguyen, Hao G

AU - Buchner, Alexander

AU - Stief, Christian G

AU - Tilki, Derya

N1 - © 2013 Published by Elsevier Inc.

PY - 2014/4

Y1 - 2014/4

N2 - OBJECTIVES: To analyze the effect of body mass index (BMI) on pathologic and functional outcomes after open radical retropubic prostatectomy.PATIENTS AND METHODS: We retrospectively analyzed 2,471 patients who underwent RP. Clinicopathologic and patient characteristics were compared with respect to patients' BMI (normal weight: BMI < 25 kg/m(2) [n = 795], overweight: BMI ≥ 25 kg/m(2) and < 30 kg/m(2) [n = 1305], and obese: BMI ≥ 30 kg/m(2) [n = 371]). Multivariable logistic and linear regression models were used to quantify the effect of BMI on pathologic and functional outcomes.RESULTS: Compared with normal weight patients, overweight and obese patients demonstrated higher pathologic Gleason grade and higher pathologic T stage, without any difference in preoperative prostate-specific antigen levels. Overweight and obese men were less likely to have a negative surgical margin (odds ratio (OR) 0.74 [confidence interval (CI) 0.65-0.84, P<0.001] for overweight men and OR 0.66 [CI 0.49-0.89, P<0.01] for obese men) and had a lower rate of postoperative erectile function (OR 0.60 [CI 0.48-0.76, P<0.001] for overweight patients and OR 0.34 [CI 0.27-0.44, P<0.001] for obese patients). Moreover, duration of surgery and intraoperative blood loss increased significantly with an increase in BMI. When using BMI as a continuous variable, the same trends were demonstrated. However, a lower rate of continence was not evident for overweight or obese men.CONCLUSIONS: In contrast to many other studies, in this cohort of patients with prostate cancer, BMI was an independent risk factor for most analyzed pathologic and functional outcomes after radical prostatectomy, including negative surgical margin, potency, duration of surgery, and intraoperative blood loss.

AB - OBJECTIVES: To analyze the effect of body mass index (BMI) on pathologic and functional outcomes after open radical retropubic prostatectomy.PATIENTS AND METHODS: We retrospectively analyzed 2,471 patients who underwent RP. Clinicopathologic and patient characteristics were compared with respect to patients' BMI (normal weight: BMI < 25 kg/m(2) [n = 795], overweight: BMI ≥ 25 kg/m(2) and < 30 kg/m(2) [n = 1305], and obese: BMI ≥ 30 kg/m(2) [n = 371]). Multivariable logistic and linear regression models were used to quantify the effect of BMI on pathologic and functional outcomes.RESULTS: Compared with normal weight patients, overweight and obese patients demonstrated higher pathologic Gleason grade and higher pathologic T stage, without any difference in preoperative prostate-specific antigen levels. Overweight and obese men were less likely to have a negative surgical margin (odds ratio (OR) 0.74 [confidence interval (CI) 0.65-0.84, P<0.001] for overweight men and OR 0.66 [CI 0.49-0.89, P<0.01] for obese men) and had a lower rate of postoperative erectile function (OR 0.60 [CI 0.48-0.76, P<0.001] for overweight patients and OR 0.34 [CI 0.27-0.44, P<0.001] for obese patients). Moreover, duration of surgery and intraoperative blood loss increased significantly with an increase in BMI. When using BMI as a continuous variable, the same trends were demonstrated. However, a lower rate of continence was not evident for overweight or obese men.CONCLUSIONS: In contrast to many other studies, in this cohort of patients with prostate cancer, BMI was an independent risk factor for most analyzed pathologic and functional outcomes after radical prostatectomy, including negative surgical margin, potency, duration of surgery, and intraoperative blood loss.

KW - Aged

KW - Body Mass Index

KW - Humans

KW - Male

KW - Middle Aged

KW - Obesity

KW - Overweight

KW - Prostatectomy

KW - Prostatic Neoplasms

KW - Recovery of Function

KW - Retrospective Studies

KW - Risk Factors

KW - Treatment Outcome

KW - Journal Article

U2 - 10.1016/j.urolonc.2013.09.005

DO - 10.1016/j.urolonc.2013.09.005

M3 - SCORING: Journal article

C2 - 24332640

VL - 32

SP - 297

EP - 302

JO - UROL ONCOL-SEMIN ORI

JF - UROL ONCOL-SEMIN ORI

SN - 1078-1439

IS - 3

ER -