The effect of anxiety on respiratory sensory gating measured by respiratory-related evoked potentials.
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The effect of anxiety on respiratory sensory gating measured by respiratory-related evoked potentials. / Chan, Pei-Ying S; Von Leupoldt, Andreas; Bradley, Margaret M; Lang, Peter J; Davenport, Paul W.
In: BIOL PSYCHOL, Vol. 91, No. 2, 2, 2012, p. 185-189.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The effect of anxiety on respiratory sensory gating measured by respiratory-related evoked potentials.
AU - Chan, Pei-Ying S
AU - Von Leupoldt, Andreas
AU - Bradley, Margaret M
AU - Lang, Peter J
AU - Davenport, Paul W
PY - 2012
Y1 - 2012
N2 - Respiratory sensory gating is evidenced by decreased amplitudes of the respiratory-related evoked potentials (RREP) N1 peak for the second (S2) compared to the first occlusion (S1) when two paired occlusions are presented with a 500-millisecond (ms) inter-stimulus-interval during one inspiration. Because anxiety is prevalent in respiratory diseases and associated with altered respiratory perception, we tested whether anxiety can modulate individuals' respiratory neural gating mechanism. By using high-density EEG, RREPs were measured in a paired inspiratory occlusion paradigm in 11 low and 10 higher anxious individuals with normal lung function. The N1 peak gating S2/S1 ratio and the N1 S2 amplitudes were greater in higher compared to low anxious individuals (p's<0.05). In addition, higher anxiety levels were correlated with greater S2/S1 ratios (r=0.54, p<0.05) and S2 amplitudes (r=-0.49, p<0.05). The results demonstrate that anxiety is associated with reduced respiratory sensory gating which might underlie altered respiratory symptom perception in anxious individuals.
AB - Respiratory sensory gating is evidenced by decreased amplitudes of the respiratory-related evoked potentials (RREP) N1 peak for the second (S2) compared to the first occlusion (S1) when two paired occlusions are presented with a 500-millisecond (ms) inter-stimulus-interval during one inspiration. Because anxiety is prevalent in respiratory diseases and associated with altered respiratory perception, we tested whether anxiety can modulate individuals' respiratory neural gating mechanism. By using high-density EEG, RREPs were measured in a paired inspiratory occlusion paradigm in 11 low and 10 higher anxious individuals with normal lung function. The N1 peak gating S2/S1 ratio and the N1 S2 amplitudes were greater in higher compared to low anxious individuals (p's<0.05). In addition, higher anxiety levels were correlated with greater S2/S1 ratios (r=0.54, p<0.05) and S2 amplitudes (r=-0.49, p<0.05). The results demonstrate that anxiety is associated with reduced respiratory sensory gating which might underlie altered respiratory symptom perception in anxious individuals.
KW - Humans
KW - Male
KW - Female
KW - Adolescent
KW - Young Adult
KW - Electroencephalography
KW - Evoked Potentials/physiology
KW - Affect/physiology
KW - Anxiety/physiopathology
KW - Perception/physiology
KW - Respiration
KW - Sensory Gating/physiology
KW - Humans
KW - Male
KW - Female
KW - Adolescent
KW - Young Adult
KW - Electroencephalography
KW - Evoked Potentials/physiology
KW - Affect/physiology
KW - Anxiety/physiopathology
KW - Perception/physiology
KW - Respiration
KW - Sensory Gating/physiology
M3 - SCORING: Journal article
VL - 91
SP - 185
EP - 189
JO - BIOL PSYCHOL
JF - BIOL PSYCHOL
SN - 0301-0511
IS - 2
M1 - 2
ER -
