The dynamics of change in striatal activity following updating training
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The dynamics of change in striatal activity following updating training. / Kühn, Simone; Schmiedek, Florian; Noack, Hannes; Wenger, Elisabeth; Bodammer, Nils C; Lindenberger, Ulman; Lövden, Martin.
In: HUM BRAIN MAPP, Vol. 34, No. 7, 07.2013, p. 1530-41.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The dynamics of change in striatal activity following updating training
AU - Kühn, Simone
AU - Schmiedek, Florian
AU - Noack, Hannes
AU - Wenger, Elisabeth
AU - Bodammer, Nils C
AU - Lindenberger, Ulman
AU - Lövden, Martin
N1 - Copyright © 2011 Wiley Periodicals, Inc.
PY - 2013/7
Y1 - 2013/7
N2 - Increases in striatal activity have been suggested to mediate training-related improvements in working-memory ability. We investigated the temporal dynamics of changes in task-related brain activity following training of working memory. Participants in an experimental group and an active control group, trained on easier tasks of a constant difficulty in shorter sessions than the experimental group, were measured before, after about 1 week, and after more than 50 days of training. In the experimental group an initial increase of working-memory related activity in the functionally defined right striatum and anatomically defined right and left putamen was followed by decreases, resulting in an inverted u-shape function that relates activity to training over time. Activity increases in the striatum developed slower in the active control group, observed at the second posttest after more than 50 days of training. In the functionally defined left striatum, initial activity increases were maintained after more extensive training and the pattern was similar for the two groups. These results shed new light on the relation between activity in the striatum (especially the putamen) and the effects of working memory training, and illustrate the importance of multiple measurements for interpreting effects of training on regional brain activity.
AB - Increases in striatal activity have been suggested to mediate training-related improvements in working-memory ability. We investigated the temporal dynamics of changes in task-related brain activity following training of working memory. Participants in an experimental group and an active control group, trained on easier tasks of a constant difficulty in shorter sessions than the experimental group, were measured before, after about 1 week, and after more than 50 days of training. In the experimental group an initial increase of working-memory related activity in the functionally defined right striatum and anatomically defined right and left putamen was followed by decreases, resulting in an inverted u-shape function that relates activity to training over time. Activity increases in the striatum developed slower in the active control group, observed at the second posttest after more than 50 days of training. In the functionally defined left striatum, initial activity increases were maintained after more extensive training and the pattern was similar for the two groups. These results shed new light on the relation between activity in the striatum (especially the putamen) and the effects of working memory training, and illustrate the importance of multiple measurements for interpreting effects of training on regional brain activity.
KW - Adult
KW - Analysis of Variance
KW - Brain Mapping
KW - Cognition
KW - Corpus Striatum
KW - Female
KW - Functional Laterality
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Learning
KW - Magnetic Resonance Imaging
KW - Male
KW - Memory, Short-Term
KW - Neuropsychological Tests
KW - Nonlinear Dynamics
KW - Oxygen
KW - Time Factors
KW - Transfer (Psychology)
KW - Young Adult
U2 - 10.1002/hbm.22007
DO - 10.1002/hbm.22007
M3 - SCORING: Journal article
C2 - 22331673
VL - 34
SP - 1530
EP - 1541
JO - HUM BRAIN MAPP
JF - HUM BRAIN MAPP
SN - 1065-9471
IS - 7
ER -
