The determination of GGT is the most reliable predictor of nonresponsiveness to interferon-alpha based therapy in HCV type-1 infection.

  • Viola Weich
  • Eva Herrmann
  • Tje Lin Chung
  • Christoph Sarrazin
  • Holger Hinrichsen
  • Peter Buggisch
  • Tilman Gerlach
  • Hartwig Klinker
  • Ulrich Spengler
  • Alexandra Bergk
  • Stefan Zeuzem
  • Thomas Berg

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Abstract

The critical analysis of baseline factors has been found to be useful to predict virologic nonresponse (NR), relapse, or sustained virologic response (SVR) in patients infected with hepatitis C virus (HCV) who receive antiviral therapy. In the present retrospective study we tried to find out whether gamma-glutamyltranspeptidase (GGT) may be one of the baseline factors which are of special predictive power. We analyzed, in patients with different treatment outcomes, the predictive power of established baseline factors either in combination with GGT or by evaluating the predictive value of GGT independently.

Bibliographical data

Original languageEnglish
Article number12
ISSN0944-1174
Publication statusPublished - 2011
pubmed 21912897