The current status and future prospects for molecular imaging-guided precision surgery

TY - JOUR

T1 - The current status and future prospects for molecular imaging-guided precision surgery

AU - Boekestijn, Imke

AU - van Oosterom, Matthias N

AU - Dell'Oglio, Paolo

AU - van Velden, Floris H P

AU - Pool, Martin

AU - Maurer, Tobias

AU - Rietbergen, Daphne D D

AU - Buckle, Tessa

AU - van Leeuwen, Fijs W B

N1 - © 2022. The Author(s).

PY - 2022/9/6

Y1 - 2022/9/6

N2 - Molecular imaging technologies are increasingly used to diagnose, monitor, and guide treatment of i.e., cancer. In this review, the current status and future prospects of the use of molecular imaging as an instrument to help realize precision surgery is addressed with focus on the main components that form the conceptual basis of intraoperative molecular imaging. Paramount for successful interventions is the relevance and accessibility of surgical targets. In addition, selection of the correct combination of imaging agents and modalities is critical to visualize both microscopic and bulk disease sites with high affinity and specificity. In this context developments within engineering/imaging physics continue to drive the growth of image-guided surgery. Particularly important herein is enhancement of sensitivity through improved contrast and spatial resolution, features that are critical if sites of cancer involvement are not to be overlooked during surgery. By facilitating the connection between surgical planning and surgical execution, digital surgery technologies such as computer-aided visualization nicely complement these technologies. The complexity of image guidance, combined with the plurality of technologies that are becoming available, also drives the need for evaluation mechanisms that can objectively score the impact that technologies exert on the performance of healthcare professionals and outcome improvement for patients.

AB - Molecular imaging technologies are increasingly used to diagnose, monitor, and guide treatment of i.e., cancer. In this review, the current status and future prospects of the use of molecular imaging as an instrument to help realize precision surgery is addressed with focus on the main components that form the conceptual basis of intraoperative molecular imaging. Paramount for successful interventions is the relevance and accessibility of surgical targets. In addition, selection of the correct combination of imaging agents and modalities is critical to visualize both microscopic and bulk disease sites with high affinity and specificity. In this context developments within engineering/imaging physics continue to drive the growth of image-guided surgery. Particularly important herein is enhancement of sensitivity through improved contrast and spatial resolution, features that are critical if sites of cancer involvement are not to be overlooked during surgery. By facilitating the connection between surgical planning and surgical execution, digital surgery technologies such as computer-aided visualization nicely complement these technologies. The complexity of image guidance, combined with the plurality of technologies that are becoming available, also drives the need for evaluation mechanisms that can objectively score the impact that technologies exert on the performance of healthcare professionals and outcome improvement for patients.

KW - Humans

KW - Molecular Imaging

KW - Neoplasms/diagnostic imaging

KW - Surgery, Computer-Assisted/methods

U2 - 10.1186/s40644-022-00482-2

DO - 10.1186/s40644-022-00482-2

M3 - SCORING: Review article

C2 - 36068619

VL - 22

JO - CANCER IMAGING

JF - CANCER IMAGING

SN - 1740-5025

IS - 1

M1 - 48

ER -