The current role of systemic chemotherapy in the primary treatment of head and neck cancer

C-J Busch; S Tribius; P Schafhausen; R Knecht

doi:10.1016/j.ctrv.2015.02.002

The current role of systemic chemotherapy in the primary treatment of head and neck cancer

Standard

The current role of systemic chemotherapy in the primary treatment of head and neck cancer. / Busch, C-J; Tribius, S; Schafhausen, P; Knecht, R.

In: CANCER TREAT REV, Vol. 41, No. 3, 01.03.2015, p. 217-21.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Busch, C-J, Tribius, S, Schafhausen, P & Knecht, R 2015, 'The current role of systemic chemotherapy in the primary treatment of head and neck cancer', CANCER TREAT REV, vol. 41, no. 3, pp. 217-21. https://doi.org/10.1016/j.ctrv.2015.02.002

APA

Busch, C-J., Tribius, S., Schafhausen, P., & Knecht, R. (2015). The current role of systemic chemotherapy in the primary treatment of head and neck cancer. CANCER TREAT REV, 41(3), 217-21. https://doi.org/10.1016/j.ctrv.2015.02.002

Vancouver

Busch C-J, Tribius S, Schafhausen P, Knecht R. The current role of systemic chemotherapy in the primary treatment of head and neck cancer. CANCER TREAT REV. 2015 Mar 1;41(3):217-21. https://doi.org/10.1016/j.ctrv.2015.02.002

Bibtex

@article{b91c4da444494210ae0a959ef7180c98,

title = "The current role of systemic chemotherapy in the primary treatment of head and neck cancer",

abstract = "The treatment of patients with locoregionally advanced squamous cell carcinoma of the head and neck (HNSCC) is still evolving into the perfect combination of the different multidisciplinary approaches. Induction chemotherapy (ICT) prior to planned definitive local therapy is widely used in this patient population for over 30 years but it is still unclear how to incorporate ICT into multimodality treatment the best. It appears to have a role in selected clinical situations especially for those patients with high risk for distant metastasis. However, since ICT protocols in different studies varies a lot, a comparative and consistent statement of benefits is difficult. We show the recent developments including randomized trials comparing radiochemotherapy (RCT) and ICT followed by definitive RCT here. This review summarizes how ICT has developed over the years, provides critical remarks of recent developments, and discusses how clinical trials including ICT should be conducted in the future.",

author = "C-J Busch and S Tribius and P Schafhausen and R Knecht",

year = "2015",

month = mar,

day = "1",

doi = "10.1016/j.ctrv.2015.02.002",

language = "English",

volume = "41",

pages = "217--21",

journal = "CANCER TREAT REV",

issn = "0305-7372",

publisher = "W.B. Saunders Ltd",

number = "3",

}

RIS

TY - JOUR

T1 - The current role of systemic chemotherapy in the primary treatment of head and neck cancer

AU - Busch, C-J

AU - Tribius, S

AU - Schafhausen, P

AU - Knecht, R

PY - 2015/3/1

Y1 - 2015/3/1

N2 - The treatment of patients with locoregionally advanced squamous cell carcinoma of the head and neck (HNSCC) is still evolving into the perfect combination of the different multidisciplinary approaches. Induction chemotherapy (ICT) prior to planned definitive local therapy is widely used in this patient population for over 30 years but it is still unclear how to incorporate ICT into multimodality treatment the best. It appears to have a role in selected clinical situations especially for those patients with high risk for distant metastasis. However, since ICT protocols in different studies varies a lot, a comparative and consistent statement of benefits is difficult. We show the recent developments including randomized trials comparing radiochemotherapy (RCT) and ICT followed by definitive RCT here. This review summarizes how ICT has developed over the years, provides critical remarks of recent developments, and discusses how clinical trials including ICT should be conducted in the future.

AB - The treatment of patients with locoregionally advanced squamous cell carcinoma of the head and neck (HNSCC) is still evolving into the perfect combination of the different multidisciplinary approaches. Induction chemotherapy (ICT) prior to planned definitive local therapy is widely used in this patient population for over 30 years but it is still unclear how to incorporate ICT into multimodality treatment the best. It appears to have a role in selected clinical situations especially for those patients with high risk for distant metastasis. However, since ICT protocols in different studies varies a lot, a comparative and consistent statement of benefits is difficult. We show the recent developments including randomized trials comparing radiochemotherapy (RCT) and ICT followed by definitive RCT here. This review summarizes how ICT has developed over the years, provides critical remarks of recent developments, and discusses how clinical trials including ICT should be conducted in the future.

U2 - 10.1016/j.ctrv.2015.02.002

DO - 10.1016/j.ctrv.2015.02.002

M3 - SCORING: Journal article

C2 - 25687982

VL - 41

SP - 217

EP - 221

JO - CANCER TREAT REV

JF - CANCER TREAT REV

SN - 0305-7372

IS - 3

ER -