The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants
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The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants. / Pajtler, Kristian W; Mack, Stephen C; Ramaswamy, Vijay; Smith, Christian A; Witt, Hendrik; Smith, Amy; Hansford, Jordan R; von Hoff, Katja; Wright, Karen D; Hwang, Eugene; Frappaz, Didier; Kanemura, Yonehiro; Massimino, Maura; Faure-Conter, Cécile; Modena, Piergiorgio; Tabori, Uri; Warren, Katherine E; Holland, Eric C; Ichimura, Koichi; Giangaspero, Felice; Castel, David; von Deimling, Andreas; Kool, Marcel; Dirks, Peter B; Grundy, Richard G; Foreman, Nicholas K; Gajjar, Amar; Korshunov, Andrey; Finlay, Jonathan; Gilbertson, Richard J; Ellison, David W; Aldape, Kenneth D; Merchant, Thomas E; Bouffet, Eric; Pfister, Stefan M; Taylor, Michael D.
In: ACTA NEUROPATHOL, Vol. 133, No. 1, 01.2017, p. 5-12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants
AU - Pajtler, Kristian W
AU - Mack, Stephen C
AU - Ramaswamy, Vijay
AU - Smith, Christian A
AU - Witt, Hendrik
AU - Smith, Amy
AU - Hansford, Jordan R
AU - von Hoff, Katja
AU - Wright, Karen D
AU - Hwang, Eugene
AU - Frappaz, Didier
AU - Kanemura, Yonehiro
AU - Massimino, Maura
AU - Faure-Conter, Cécile
AU - Modena, Piergiorgio
AU - Tabori, Uri
AU - Warren, Katherine E
AU - Holland, Eric C
AU - Ichimura, Koichi
AU - Giangaspero, Felice
AU - Castel, David
AU - von Deimling, Andreas
AU - Kool, Marcel
AU - Dirks, Peter B
AU - Grundy, Richard G
AU - Foreman, Nicholas K
AU - Gajjar, Amar
AU - Korshunov, Andrey
AU - Finlay, Jonathan
AU - Gilbertson, Richard J
AU - Ellison, David W
AU - Aldape, Kenneth D
AU - Merchant, Thomas E
AU - Bouffet, Eric
AU - Pfister, Stefan M
AU - Taylor, Michael D
PY - 2017/1
Y1 - 2017/1
N2 - Multiple independent genomic profiling efforts have recently identified clinically and molecularly distinct subgroups of ependymoma arising from all three anatomic compartments of the central nervous system (supratentorial brain, posterior fossa, and spinal cord). These advances motivated a consensus meeting to discuss: (1) the utility of current histologic grading criteria, (2) the integration of molecular-based stratification schemes in future clinical trials for patients with ependymoma and (3) current therapy in the context of molecular subgroups. Discussion at the meeting generated a series of consensus statements and recommendations from the attendees, which comment on the prognostic evaluation and treatment decisions of patients with intracranial ependymoma (WHO Grade II/III) based on the knowledge of its molecular subgroups. The major consensus among attendees was reached that treatment decisions for ependymoma (outside of clinical trials) should not be based on grading (II vs III). Supratentorial and posterior fossa ependymomas are distinct diseases, although the impact on therapy is still evolving. Molecular subgrouping should be part of all clinical trials henceforth.
AB - Multiple independent genomic profiling efforts have recently identified clinically and molecularly distinct subgroups of ependymoma arising from all three anatomic compartments of the central nervous system (supratentorial brain, posterior fossa, and spinal cord). These advances motivated a consensus meeting to discuss: (1) the utility of current histologic grading criteria, (2) the integration of molecular-based stratification schemes in future clinical trials for patients with ependymoma and (3) current therapy in the context of molecular subgroups. Discussion at the meeting generated a series of consensus statements and recommendations from the attendees, which comment on the prognostic evaluation and treatment decisions of patients with intracranial ependymoma (WHO Grade II/III) based on the knowledge of its molecular subgroups. The major consensus among attendees was reached that treatment decisions for ependymoma (outside of clinical trials) should not be based on grading (II vs III). Supratentorial and posterior fossa ependymomas are distinct diseases, although the impact on therapy is still evolving. Molecular subgrouping should be part of all clinical trials henceforth.
U2 - 10.1007/s00401-016-1643-0
DO - 10.1007/s00401-016-1643-0
M3 - SCORING: Journal article
C2 - 27858204
VL - 133
SP - 5
EP - 12
JO - ACTA NEUROPATHOL
JF - ACTA NEUROPATHOL
SN - 0001-6322
IS - 1
ER -