Research ExplorerPublicationsThe Clinical Features and Immunological Signature of Cyclosp...

The Clinical Features and Immunological Signature of Cyclospora cayetanensis Co-Infection among People Living with HIV in Ghana

Standard

The Clinical Features and Immunological Signature of Cyclospora cayetanensis Co-Infection among People Living with HIV in Ghana. / Sarfo, Fred Stephen; Dompreh, Albert; Asibey, Shadrack Osei; Boateng, Richard; Weinreich, Felix; Kuffour, Edmund Osei; Norman, Betty; Di Cristanziano, Veronica; Frickmann, Hagen; Feldt, Torsten; Eberhardt, Kirsten Alexandra.

In: MICROORGANISMS, Vol. 10, No. 7, 1407, 13.07.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sarfo, FS, Dompreh, A, Asibey, SO, Boateng, R, Weinreich, F, Kuffour, EO, Norman, B, Di Cristanziano, V, Frickmann, H, Feldt, T & Eberhardt, KA 2022, 'The Clinical Features and Immunological Signature of Cyclospora cayetanensis Co-Infection among People Living with HIV in Ghana', MICROORGANISMS, vol. 10, no. 7, 1407. https://doi.org/10.3390/microorganisms10071407

APA

Sarfo, F. S., Dompreh, A., Asibey, S. O., Boateng, R., Weinreich, F., Kuffour, E. O., Norman, B., Di Cristanziano, V., Frickmann, H., Feldt, T., & Eberhardt, K. A. (2022). The Clinical Features and Immunological Signature of Cyclospora cayetanensis Co-Infection among People Living with HIV in Ghana. MICROORGANISMS, 10(7), [1407]. https://doi.org/10.3390/microorganisms10071407

Vancouver

Sarfo FS, Dompreh A, Asibey SO, Boateng R, Weinreich F, Kuffour EO et al. The Clinical Features and Immunological Signature of Cyclospora cayetanensis Co-Infection among People Living with HIV in Ghana. MICROORGANISMS. 2022 Jul 13;10(7). 1407. https://doi.org/10.3390/microorganisms10071407

Bibtex

@article{fb0ccf252c834ae7aae3804f58a9e8ad,
title = "The Clinical Features and Immunological Signature of Cyclospora cayetanensis Co-Infection among People Living with HIV in Ghana",
abstract = "Background: There is a paucity of information on the contemporary burden, disease patterns, and immunological profile of people living with HIV who are co-infected with C. cayetanensis in the post-antiretroviral therapy era. Methods: For this cross-sectional study, stool samples of 640 HIV-positive and 83 HIV-negative individuals in Ghana were tested for C. cayetanensis. Additionally, sociodemographic parameters, clinical symptoms, medical drug intake, and immunological parameters were assessed. Results: The prevalence of C. cayetanensis was 8.75% (n = 56) in HIV-positive and 1.20% (n = 1) in HIV-negative participants (p = 0.015). Within the group of HIV-positive participants, the prevalence reached 13.6% in patients with CD4+ T cell counts below 200 cells/µl. Frequencies of the clinical manifestations of weight loss and diarrheal disease were significantly higher in patients with C. cayetanensis compared to those without co-infection (36.36% vs. 22.59%, p = 0.034 and 20.00% vs. 4.90%, p < 0.001, respectively). The expression of markers of immune activation and exhaustion of T lymphocyte sub-populations was significantly elevated in patients colonized with C. cayetanensis. Conclusions: In the modern post-combined antiretroviral therapy (cART) era, the acquisition of C. cayetanensis among PLWH in Ghana is driven largely by the immunosuppression profile characterized by high expression of markers of immune activation and immune exhaustion.",
author = "Sarfo, {Fred Stephen} and Albert Dompreh and Asibey, {Shadrack Osei} and Richard Boateng and Felix Weinreich and Kuffour, {Edmund Osei} and Betty Norman and {Di Cristanziano}, Veronica and Hagen Frickmann and Torsten Feldt and Eberhardt, {Kirsten Alexandra}",
year = "2022",
month = jul,
day = "13",
doi = "10.3390/microorganisms10071407",
language = "English",
volume = "10",
journal = "MICROORGANISMS",
issn = "2076-2607",
publisher = "MDPI AG",
number = "7",

}

RIS

TY - JOUR

T1 - The Clinical Features and Immunological Signature of Cyclospora cayetanensis Co-Infection among People Living with HIV in Ghana

AU - Sarfo, Fred Stephen

AU - Dompreh, Albert

AU - Asibey, Shadrack Osei

AU - Boateng, Richard

AU - Weinreich, Felix

AU - Kuffour, Edmund Osei

AU - Norman, Betty

AU - Di Cristanziano, Veronica

AU - Frickmann, Hagen

AU - Feldt, Torsten

AU - Eberhardt, Kirsten Alexandra

PY - 2022/7/13

Y1 - 2022/7/13

N2 - Background: There is a paucity of information on the contemporary burden, disease patterns, and immunological profile of people living with HIV who are co-infected with C. cayetanensis in the post-antiretroviral therapy era. Methods: For this cross-sectional study, stool samples of 640 HIV-positive and 83 HIV-negative individuals in Ghana were tested for C. cayetanensis. Additionally, sociodemographic parameters, clinical symptoms, medical drug intake, and immunological parameters were assessed. Results: The prevalence of C. cayetanensis was 8.75% (n = 56) in HIV-positive and 1.20% (n = 1) in HIV-negative participants (p = 0.015). Within the group of HIV-positive participants, the prevalence reached 13.6% in patients with CD4+ T cell counts below 200 cells/µl. Frequencies of the clinical manifestations of weight loss and diarrheal disease were significantly higher in patients with C. cayetanensis compared to those without co-infection (36.36% vs. 22.59%, p = 0.034 and 20.00% vs. 4.90%, p < 0.001, respectively). The expression of markers of immune activation and exhaustion of T lymphocyte sub-populations was significantly elevated in patients colonized with C. cayetanensis. Conclusions: In the modern post-combined antiretroviral therapy (cART) era, the acquisition of C. cayetanensis among PLWH in Ghana is driven largely by the immunosuppression profile characterized by high expression of markers of immune activation and immune exhaustion.

AB - Background: There is a paucity of information on the contemporary burden, disease patterns, and immunological profile of people living with HIV who are co-infected with C. cayetanensis in the post-antiretroviral therapy era. Methods: For this cross-sectional study, stool samples of 640 HIV-positive and 83 HIV-negative individuals in Ghana were tested for C. cayetanensis. Additionally, sociodemographic parameters, clinical symptoms, medical drug intake, and immunological parameters were assessed. Results: The prevalence of C. cayetanensis was 8.75% (n = 56) in HIV-positive and 1.20% (n = 1) in HIV-negative participants (p = 0.015). Within the group of HIV-positive participants, the prevalence reached 13.6% in patients with CD4+ T cell counts below 200 cells/µl. Frequencies of the clinical manifestations of weight loss and diarrheal disease were significantly higher in patients with C. cayetanensis compared to those without co-infection (36.36% vs. 22.59%, p = 0.034 and 20.00% vs. 4.90%, p < 0.001, respectively). The expression of markers of immune activation and exhaustion of T lymphocyte sub-populations was significantly elevated in patients colonized with C. cayetanensis. Conclusions: In the modern post-combined antiretroviral therapy (cART) era, the acquisition of C. cayetanensis among PLWH in Ghana is driven largely by the immunosuppression profile characterized by high expression of markers of immune activation and immune exhaustion.

U2 - 10.3390/microorganisms10071407

DO - 10.3390/microorganisms10071407

M3 - SCORING: Journal article

C2 - 35889126

VL - 10

JO - MICROORGANISMS

JF - MICROORGANISMS

SN - 2076-2607

IS - 7

M1 - 1407

ER -