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The changing scene of allogeneic stem cell transplantation for chronic myeloid leukemia-a report from the German Registry covering the period from 1998 to 2004.

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The changing scene of allogeneic stem cell transplantation for chronic myeloid leukemia-a report from the German Registry covering the period from 1998 to 2004. / Bacher, Ulrike; Klyuchnikov, Evgeny; Zabelina, Tatjana; Ottinger, Hellmut; Beelen, Dietrich; Schrezenmeier, Hubert; Ehninger, Gerhard; Müller, Carlheinz; Berger, Jürgen; Suttorp, Meinolf; Kolb, Hans-Jochem; Kröger, Nicolaus; Zander, Axel R.

In: ANN HEMATOL, 2009.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bacher, U, Klyuchnikov, E, Zabelina, T, Ottinger, H, Beelen, D, Schrezenmeier, H, Ehninger, G, Müller, C, Berger, J, Suttorp, M, Kolb, H-J, Kröger, N & Zander, AR 2009, 'The changing scene of allogeneic stem cell transplantation for chronic myeloid leukemia-a report from the German Registry covering the period from 1998 to 2004.', ANN HEMATOL. <http://www.ncbi.nlm.nih.gov/pubmed/19319532?dopt=Citation>

APA

Bacher, U., Klyuchnikov, E., Zabelina, T., Ottinger, H., Beelen, D., Schrezenmeier, H., Ehninger, G., Müller, C., Berger, J., Suttorp, M., Kolb, H-J., Kröger, N., & Zander, A. R. (2009). The changing scene of allogeneic stem cell transplantation for chronic myeloid leukemia-a report from the German Registry covering the period from 1998 to 2004. ANN HEMATOL. http://www.ncbi.nlm.nih.gov/pubmed/19319532?dopt=Citation

Vancouver

Bacher U, Klyuchnikov E, Zabelina T, Ottinger H, Beelen D, Schrezenmeier H et al. The changing scene of allogeneic stem cell transplantation for chronic myeloid leukemia-a report from the German Registry covering the period from 1998 to 2004. ANN HEMATOL. 2009.

Bibtex

@article{d55ae5f37eea451ea293ab679b1dc29f,
title = "The changing scene of allogeneic stem cell transplantation for chronic myeloid leukemia-a report from the German Registry covering the period from 1998 to 2004.",
abstract = "Due to the recent changes in the indication to allogeneic stem cell transplantation (SCT) in chronic myeloid leukemia (CML), we retrospectively analyzed 1,716 patients with different CML stages who received an allograft from related (n = 767) or unrelated donors (n = 938) within the German Registry of Stem Cell Transplantation (DRST) from 1998 to 2004. Myeloablative conditioning was performed in 724/871 cases (83%), dose-reduced conditioning in 147/871 (17%). Annual transplantations were decreasing from 357 to 98 (28%) in the period of study, but the proportion of advanced cases was increasing from 32% (112/346) to 53% (50/94) of all SCTs. Stage of disease, intervals from diagnosis, and patients' age were independent prognostic parameters, while peripheral stem cells and unrelated transplantation seemed equal to bone marrow/related transplantation. This study demonstrates that allo-SCT still has an important role in advanced CML, which emphasizes the need for optimized transplantation strategies for these high-risk patients.",
author = "Ulrike Bacher and Evgeny Klyuchnikov and Tatjana Zabelina and Hellmut Ottinger and Dietrich Beelen and Hubert Schrezenmeier and Gerhard Ehninger and Carlheinz M{\"u}ller and J{\"u}rgen Berger and Meinolf Suttorp and Hans-Jochem Kolb and Nicolaus Kr{\"o}ger and Zander, {Axel R.}",
year = "2009",
language = "Deutsch",
journal = "ANN HEMATOL",
issn = "0939-5555",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - The changing scene of allogeneic stem cell transplantation for chronic myeloid leukemia-a report from the German Registry covering the period from 1998 to 2004.

AU - Bacher, Ulrike

AU - Klyuchnikov, Evgeny

AU - Zabelina, Tatjana

AU - Ottinger, Hellmut

AU - Beelen, Dietrich

AU - Schrezenmeier, Hubert

AU - Ehninger, Gerhard

AU - Müller, Carlheinz

AU - Berger, Jürgen

AU - Suttorp, Meinolf

AU - Kolb, Hans-Jochem

AU - Kröger, Nicolaus

AU - Zander, Axel R.

PY - 2009

Y1 - 2009

N2 - Due to the recent changes in the indication to allogeneic stem cell transplantation (SCT) in chronic myeloid leukemia (CML), we retrospectively analyzed 1,716 patients with different CML stages who received an allograft from related (n = 767) or unrelated donors (n = 938) within the German Registry of Stem Cell Transplantation (DRST) from 1998 to 2004. Myeloablative conditioning was performed in 724/871 cases (83%), dose-reduced conditioning in 147/871 (17%). Annual transplantations were decreasing from 357 to 98 (28%) in the period of study, but the proportion of advanced cases was increasing from 32% (112/346) to 53% (50/94) of all SCTs. Stage of disease, intervals from diagnosis, and patients' age were independent prognostic parameters, while peripheral stem cells and unrelated transplantation seemed equal to bone marrow/related transplantation. This study demonstrates that allo-SCT still has an important role in advanced CML, which emphasizes the need for optimized transplantation strategies for these high-risk patients.

AB - Due to the recent changes in the indication to allogeneic stem cell transplantation (SCT) in chronic myeloid leukemia (CML), we retrospectively analyzed 1,716 patients with different CML stages who received an allograft from related (n = 767) or unrelated donors (n = 938) within the German Registry of Stem Cell Transplantation (DRST) from 1998 to 2004. Myeloablative conditioning was performed in 724/871 cases (83%), dose-reduced conditioning in 147/871 (17%). Annual transplantations were decreasing from 357 to 98 (28%) in the period of study, but the proportion of advanced cases was increasing from 32% (112/346) to 53% (50/94) of all SCTs. Stage of disease, intervals from diagnosis, and patients' age were independent prognostic parameters, while peripheral stem cells and unrelated transplantation seemed equal to bone marrow/related transplantation. This study demonstrates that allo-SCT still has an important role in advanced CML, which emphasizes the need for optimized transplantation strategies for these high-risk patients.

M3 - SCORING: Zeitschriftenaufsatz

JO - ANN HEMATOL

JF - ANN HEMATOL

SN - 0939-5555

ER -