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The challenge of mapping the human connectome based on diffusion tractography

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The challenge of mapping the human connectome based on diffusion tractography. / Maier-Hein, Klaus H; Neher, Peter F; Houde, Jean-Christophe; Côté, Marc-Alexandre; Garyfallidis, Eleftherios; Zhong, Jidan; Chamberland, Maxime; Yeh, Fang-Cheng; Lin, Ying-Chia; Ji, Qing; Reddick, Wilburn E; Glass, John O; Chen, David Qixiang; Feng, Yuanjing; Gao, Chengfeng; Wu, Ye; Ma, Jieyan; Renjie, H; Li, Qiang; Westin, Carl-Fredrik; Deslauriers-Gauthier, Samuel; González, J Omar Ocegueda; Paquette, Michael; St-Jean, Samuel; Girard, Gabriel; Rheault, François; Sidhu, Jasmeen; Tax, Chantal M W; Guo, Fenghua; Mesri, Hamed Y; Dávid, Szabolcs; Froeling, Martijn; Heemskerk, Anneriet M; Leemans, Alexander; Boré, Arnaud; Pinsard, Basile; Bedetti, Christophe; Desrosiers, Matthieu; Brambati, Simona; Doyon, Julien; Sarica, Alessia; Vasta, Roberta; Cerasa, Antonio; Quattrone, Aldo; Yeatman, Jason; Khan, Ali R; Hodges, Wes; Alexander, Simon; Romascano, David; Barakovic, Muhamed; Auría, Anna; Esteban, Oscar; Lemkaddem, Alia; Thiran, Jean-Philippe; Cetingul, H Ertan; Odry, Benjamin L; Mailhe, Boris; Nadar, Mariappan S; Pizzagalli, Fabrizio; Prasad, Gautam; Villalon-Reina, Julio E; Galvis, Justin; Thompson, Paul M; Requejo, Francisco De Santiago; Laguna, Pedro Luque; Lacerda, Luis Miguel; Barrett, Rachel; Dell'Acqua, Flavio; Catani, Marco; Petit, Laurent; Caruyer, Emmanuel; Daducci, Alessandro; Dyrby, Tim B; Holland-Letz, Tim; Hilgetag, Claus C; Stieltjes, Bram; Descoteaux, Maxime.

In: NAT COMMUN, Vol. 8, No. 1, 07.11.2017, p. 1349.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Maier-Hein, KH, Neher, PF, Houde, J-C, Côté, M-A, Garyfallidis, E, Zhong, J, Chamberland, M, Yeh, F-C, Lin, Y-C, Ji, Q, Reddick, WE, Glass, JO, Chen, DQ, Feng, Y, Gao, C, Wu, Y, Ma, J, Renjie, H, Li, Q, Westin, C-F, Deslauriers-Gauthier, S, González, JOO, Paquette, M, St-Jean, S, Girard, G, Rheault, F, Sidhu, J, Tax, CMW, Guo, F, Mesri, HY, Dávid, S, Froeling, M, Heemskerk, AM, Leemans, A, Boré, A, Pinsard, B, Bedetti, C, Desrosiers, M, Brambati, S, Doyon, J, Sarica, A, Vasta, R, Cerasa, A, Quattrone, A, Yeatman, J, Khan, AR, Hodges, W, Alexander, S, Romascano, D, Barakovic, M, Auría, A, Esteban, O, Lemkaddem, A, Thiran, J-P, Cetingul, HE, Odry, BL, Mailhe, B, Nadar, MS, Pizzagalli, F, Prasad, G, Villalon-Reina, JE, Galvis, J, Thompson, PM, Requejo, FDS, Laguna, PL, Lacerda, LM, Barrett, R, Dell'Acqua, F, Catani, M, Petit, L, Caruyer, E, Daducci, A, Dyrby, TB, Holland-Letz, T, Hilgetag, CC, Stieltjes, B & Descoteaux, M 2017, 'The challenge of mapping the human connectome based on diffusion tractography', NAT COMMUN, vol. 8, no. 1, pp. 1349. https://doi.org/10.1038/s41467-017-01285-x

APA

Maier-Hein, K. H., Neher, P. F., Houde, J-C., Côté, M-A., Garyfallidis, E., Zhong, J., Chamberland, M., Yeh, F-C., Lin, Y-C., Ji, Q., Reddick, W. E., Glass, J. O., Chen, D. Q., Feng, Y., Gao, C., Wu, Y., Ma, J., Renjie, H., Li, Q., ... Descoteaux, M. (2017). The challenge of mapping the human connectome based on diffusion tractography. NAT COMMUN, 8(1), 1349. https://doi.org/10.1038/s41467-017-01285-x

Vancouver

Maier-Hein KH, Neher PF, Houde J-C, Côté M-A, Garyfallidis E, Zhong J et al. The challenge of mapping the human connectome based on diffusion tractography. NAT COMMUN. 2017 Nov 7;8(1):1349. https://doi.org/10.1038/s41467-017-01285-x

Bibtex

@article{1e96471d2fb84408b6e4a6390518192e,
title = "The challenge of mapping the human connectome based on diffusion tractography",
abstract = "Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent). However, the same tractograms contain many more invalid than valid bundles, and half of these invalid bundles occur systematically across research groups. Taken together, our results demonstrate and confirm fundamental ambiguities inherent in tract reconstruction based on orientation information alone, which need to be considered when interpreting tractography and connectivity results. Our approach provides a novel framework for estimating reliability of tractography and encourages innovation to address its current limitations.",
keywords = "Journal Article",
author = "Maier-Hein, {Klaus H} and Neher, {Peter F} and Jean-Christophe Houde and Marc-Alexandre C{\^o}t{\'e} and Eleftherios Garyfallidis and Jidan Zhong and Maxime Chamberland and Fang-Cheng Yeh and Ying-Chia Lin and Qing Ji and Reddick, {Wilburn E} and Glass, {John O} and Chen, {David Qixiang} and Yuanjing Feng and Chengfeng Gao and Ye Wu and Jieyan Ma and H Renjie and Qiang Li and Carl-Fredrik Westin and Samuel Deslauriers-Gauthier and Gonz{\'a}lez, {J Omar Ocegueda} and Michael Paquette and Samuel St-Jean and Gabriel Girard and Fran{\c c}ois Rheault and Jasmeen Sidhu and Tax, {Chantal M W} and Fenghua Guo and Mesri, {Hamed Y} and Szabolcs D{\'a}vid and Martijn Froeling and Heemskerk, {Anneriet M} and Alexander Leemans and Arnaud Bor{\'e} and Basile Pinsard and Christophe Bedetti and Matthieu Desrosiers and Simona Brambati and Julien Doyon and Alessia Sarica and Roberta Vasta and Antonio Cerasa and Aldo Quattrone and Jason Yeatman and Khan, {Ali R} and Wes Hodges and Simon Alexander and David Romascano and Muhamed Barakovic and Anna Aur{\'i}a and Oscar Esteban and Alia Lemkaddem and Jean-Philippe Thiran and Cetingul, {H Ertan} and Odry, {Benjamin L} and Boris Mailhe and Nadar, {Mariappan S} and Fabrizio Pizzagalli and Gautam Prasad and Villalon-Reina, {Julio E} and Justin Galvis and Thompson, {Paul M} and Requejo, {Francisco De Santiago} and Laguna, {Pedro Luque} and Lacerda, {Luis Miguel} and Rachel Barrett and Flavio Dell'Acqua and Marco Catani and Laurent Petit and Emmanuel Caruyer and Alessandro Daducci and Dyrby, {Tim B} and Tim Holland-Letz and Hilgetag, {Claus C} and Bram Stieltjes and Maxime Descoteaux",
year = "2017",
month = nov,
day = "7",
doi = "10.1038/s41467-017-01285-x",
language = "English",
volume = "8",
pages = "1349",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - The challenge of mapping the human connectome based on diffusion tractography

AU - Maier-Hein, Klaus H

AU - Neher, Peter F

AU - Houde, Jean-Christophe

AU - Côté, Marc-Alexandre

AU - Garyfallidis, Eleftherios

AU - Zhong, Jidan

AU - Chamberland, Maxime

AU - Yeh, Fang-Cheng

AU - Lin, Ying-Chia

AU - Ji, Qing

AU - Reddick, Wilburn E

AU - Glass, John O

AU - Chen, David Qixiang

AU - Feng, Yuanjing

AU - Gao, Chengfeng

AU - Wu, Ye

AU - Ma, Jieyan

AU - Renjie, H

AU - Li, Qiang

AU - Westin, Carl-Fredrik

AU - Deslauriers-Gauthier, Samuel

AU - González, J Omar Ocegueda

AU - Paquette, Michael

AU - St-Jean, Samuel

AU - Girard, Gabriel

AU - Rheault, François

AU - Sidhu, Jasmeen

AU - Tax, Chantal M W

AU - Guo, Fenghua

AU - Mesri, Hamed Y

AU - Dávid, Szabolcs

AU - Froeling, Martijn

AU - Heemskerk, Anneriet M

AU - Leemans, Alexander

AU - Boré, Arnaud

AU - Pinsard, Basile

AU - Bedetti, Christophe

AU - Desrosiers, Matthieu

AU - Brambati, Simona

AU - Doyon, Julien

AU - Sarica, Alessia

AU - Vasta, Roberta

AU - Cerasa, Antonio

AU - Quattrone, Aldo

AU - Yeatman, Jason

AU - Khan, Ali R

AU - Hodges, Wes

AU - Alexander, Simon

AU - Romascano, David

AU - Barakovic, Muhamed

AU - Auría, Anna

AU - Esteban, Oscar

AU - Lemkaddem, Alia

AU - Thiran, Jean-Philippe

AU - Cetingul, H Ertan

AU - Odry, Benjamin L

AU - Mailhe, Boris

AU - Nadar, Mariappan S

AU - Pizzagalli, Fabrizio

AU - Prasad, Gautam

AU - Villalon-Reina, Julio E

AU - Galvis, Justin

AU - Thompson, Paul M

AU - Requejo, Francisco De Santiago

AU - Laguna, Pedro Luque

AU - Lacerda, Luis Miguel

AU - Barrett, Rachel

AU - Dell'Acqua, Flavio

AU - Catani, Marco

AU - Petit, Laurent

AU - Caruyer, Emmanuel

AU - Daducci, Alessandro

AU - Dyrby, Tim B

AU - Holland-Letz, Tim

AU - Hilgetag, Claus C

AU - Stieltjes, Bram

AU - Descoteaux, Maxime

PY - 2017/11/7

Y1 - 2017/11/7

N2 - Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent). However, the same tractograms contain many more invalid than valid bundles, and half of these invalid bundles occur systematically across research groups. Taken together, our results demonstrate and confirm fundamental ambiguities inherent in tract reconstruction based on orientation information alone, which need to be considered when interpreting tractography and connectivity results. Our approach provides a novel framework for estimating reliability of tractography and encourages innovation to address its current limitations.

AB - Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent). However, the same tractograms contain many more invalid than valid bundles, and half of these invalid bundles occur systematically across research groups. Taken together, our results demonstrate and confirm fundamental ambiguities inherent in tract reconstruction based on orientation information alone, which need to be considered when interpreting tractography and connectivity results. Our approach provides a novel framework for estimating reliability of tractography and encourages innovation to address its current limitations.

KW - Journal Article

U2 - 10.1038/s41467-017-01285-x

DO - 10.1038/s41467-017-01285-x

M3 - SCORING: Journal article

C2 - 29116093

VL - 8

SP - 1349

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -