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The CD28 related molecule ICOS

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The CD28 related molecule ICOS : T cell modulation in the presence and absence of B7.1/2 and regulational expression in multiple sclerosis. / Wiendl, Heinz; Neuhaus, Oliver; Mehling, Matthias; Wintterle, Sabine; Schreiner, Bettina; Mitsdoerffer, Meike; Wienhold, Wolfgang; Weissert, Robert; Wessels, Johannes; Hartung, Hans-Peter; Weller, Michael; Tolosa, Eva; Melms, Arthur.

In: J NEUROIMMUNOL, Vol. 140, No. 1-2, 01.07.2003, p. 177-87.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wiendl, H, Neuhaus, O, Mehling, M, Wintterle, S, Schreiner, B, Mitsdoerffer, M, Wienhold, W, Weissert, R, Wessels, J, Hartung, H-P, Weller, M, Tolosa, E & Melms, A 2003, 'The CD28 related molecule ICOS: T cell modulation in the presence and absence of B7.1/2 and regulational expression in multiple sclerosis', J NEUROIMMUNOL, vol. 140, no. 1-2, pp. 177-87.

APA

Wiendl, H., Neuhaus, O., Mehling, M., Wintterle, S., Schreiner, B., Mitsdoerffer, M., Wienhold, W., Weissert, R., Wessels, J., Hartung, H-P., Weller, M., Tolosa, E., & Melms, A. (2003). The CD28 related molecule ICOS: T cell modulation in the presence and absence of B7.1/2 and regulational expression in multiple sclerosis. J NEUROIMMUNOL, 140(1-2), 177-87.

Vancouver

Wiendl H, Neuhaus O, Mehling M, Wintterle S, Schreiner B, Mitsdoerffer M et al. The CD28 related molecule ICOS: T cell modulation in the presence and absence of B7.1/2 and regulational expression in multiple sclerosis. J NEUROIMMUNOL. 2003 Jul 1;140(1-2):177-87.

Bibtex

@article{03d80b4b6d914b81bc9c35a35f499252,
title = "The CD28 related molecule ICOS: T cell modulation in the presence and absence of B7.1/2 and regulational expression in multiple sclerosis",
abstract = "Costimulatory signals play a key role in regulating T cell activation and are believed to have decisive influence in the inciting and perpetuating cellular effector mechanisms in autoimmune diseases such as multiple sclerosis (MS). Inducible costimulator protein (ICOS), a recently identified member of the CD28-family, presumably affects the differentiation of Th1/Th2 cells after primary activation and modulates the immune response of effector/memory T cells. This study examines the expression and functional role of ICOS costimulation in healthy donors and patients with MS. After nonspecific or antigen-specific stimulation, ICOS is preferentially expressed on CD4 Th2-T cells. ICOS-costimulation affects the production of Th1 and Th2 cytokines both in the absence and presence of B7/CD28 costimulation, thus suggesting that ICOS costimulation can modulate cytokine secretion also in a CD28-independent manner. Levels of constitutive and inducible ICOS expression on human T cell subsets from peripheral blood were quantified in healthy donors and patients with MS. Constitutive expression of ICOS on T cells varies between 0.1% and 42.3%. There were no significant differences between both groups in the baseline expression or inducibility of ICOS on CD4 or CD8 T cells. ICOS expression could be demonstrated on CSF T lymphocytes in patients with acute MS relapses but was not elevated compared with peripheral blood. In essence we show that ICOS is upregulated on human T cells after stimulation and can modulate both Th1 and Th2 cytokine production in the absence and presence of B7-costimulation. In MS patients we demonstrate the functionality of the ICOS costimulatory pathway. Potential implications of ICOSL/ICOS interactions for MS immunopathogenesis are discussed.",
keywords = "Adjuvants, Immunologic, Adult, Animals, Antigens, CD, Antigens, CD28, Antigens, CD80, Antigens, CD86, Antigens, Differentiation, T-Lymphocyte, Cell Line, Coculture Techniques, Female, Flow Cytometry, Humans, Inducible T-Cell Co-Stimulator Protein, Interferon-beta, Interferon-gamma, Interleukin-4, L Cells (Cell Line), Male, Membrane Glycoproteins, Mice, Middle Aged, Multiple Sclerosis, Peptides, Receptors, Chemokine, T-Lymphocyte Subsets, Th1 Cells, Th2 Cells, Transfection, Up-Regulation",
author = "Heinz Wiendl and Oliver Neuhaus and Matthias Mehling and Sabine Wintterle and Bettina Schreiner and Meike Mitsdoerffer and Wolfgang Wienhold and Robert Weissert and Johannes Wessels and Hans-Peter Hartung and Michael Weller and Eva Tolosa and Arthur Melms",
year = "2003",
month = jul,
day = "1",
language = "English",
volume = "140",
pages = "177--87",
journal = "J NEUROIMMUNOL",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - The CD28 related molecule ICOS

T2 - T cell modulation in the presence and absence of B7.1/2 and regulational expression in multiple sclerosis

AU - Wiendl, Heinz

AU - Neuhaus, Oliver

AU - Mehling, Matthias

AU - Wintterle, Sabine

AU - Schreiner, Bettina

AU - Mitsdoerffer, Meike

AU - Wienhold, Wolfgang

AU - Weissert, Robert

AU - Wessels, Johannes

AU - Hartung, Hans-Peter

AU - Weller, Michael

AU - Tolosa, Eva

AU - Melms, Arthur

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Costimulatory signals play a key role in regulating T cell activation and are believed to have decisive influence in the inciting and perpetuating cellular effector mechanisms in autoimmune diseases such as multiple sclerosis (MS). Inducible costimulator protein (ICOS), a recently identified member of the CD28-family, presumably affects the differentiation of Th1/Th2 cells after primary activation and modulates the immune response of effector/memory T cells. This study examines the expression and functional role of ICOS costimulation in healthy donors and patients with MS. After nonspecific or antigen-specific stimulation, ICOS is preferentially expressed on CD4 Th2-T cells. ICOS-costimulation affects the production of Th1 and Th2 cytokines both in the absence and presence of B7/CD28 costimulation, thus suggesting that ICOS costimulation can modulate cytokine secretion also in a CD28-independent manner. Levels of constitutive and inducible ICOS expression on human T cell subsets from peripheral blood were quantified in healthy donors and patients with MS. Constitutive expression of ICOS on T cells varies between 0.1% and 42.3%. There were no significant differences between both groups in the baseline expression or inducibility of ICOS on CD4 or CD8 T cells. ICOS expression could be demonstrated on CSF T lymphocytes in patients with acute MS relapses but was not elevated compared with peripheral blood. In essence we show that ICOS is upregulated on human T cells after stimulation and can modulate both Th1 and Th2 cytokine production in the absence and presence of B7-costimulation. In MS patients we demonstrate the functionality of the ICOS costimulatory pathway. Potential implications of ICOSL/ICOS interactions for MS immunopathogenesis are discussed.

AB - Costimulatory signals play a key role in regulating T cell activation and are believed to have decisive influence in the inciting and perpetuating cellular effector mechanisms in autoimmune diseases such as multiple sclerosis (MS). Inducible costimulator protein (ICOS), a recently identified member of the CD28-family, presumably affects the differentiation of Th1/Th2 cells after primary activation and modulates the immune response of effector/memory T cells. This study examines the expression and functional role of ICOS costimulation in healthy donors and patients with MS. After nonspecific or antigen-specific stimulation, ICOS is preferentially expressed on CD4 Th2-T cells. ICOS-costimulation affects the production of Th1 and Th2 cytokines both in the absence and presence of B7/CD28 costimulation, thus suggesting that ICOS costimulation can modulate cytokine secretion also in a CD28-independent manner. Levels of constitutive and inducible ICOS expression on human T cell subsets from peripheral blood were quantified in healthy donors and patients with MS. Constitutive expression of ICOS on T cells varies between 0.1% and 42.3%. There were no significant differences between both groups in the baseline expression or inducibility of ICOS on CD4 or CD8 T cells. ICOS expression could be demonstrated on CSF T lymphocytes in patients with acute MS relapses but was not elevated compared with peripheral blood. In essence we show that ICOS is upregulated on human T cells after stimulation and can modulate both Th1 and Th2 cytokine production in the absence and presence of B7-costimulation. In MS patients we demonstrate the functionality of the ICOS costimulatory pathway. Potential implications of ICOSL/ICOS interactions for MS immunopathogenesis are discussed.

KW - Adjuvants, Immunologic

KW - Adult

KW - Animals

KW - Antigens, CD

KW - Antigens, CD28

KW - Antigens, CD80

KW - Antigens, CD86

KW - Antigens, Differentiation, T-Lymphocyte

KW - Cell Line

KW - Coculture Techniques

KW - Female

KW - Flow Cytometry

KW - Humans

KW - Inducible T-Cell Co-Stimulator Protein

KW - Interferon-beta

KW - Interferon-gamma

KW - Interleukin-4

KW - L Cells (Cell Line)

KW - Male

KW - Membrane Glycoproteins

KW - Mice

KW - Middle Aged

KW - Multiple Sclerosis

KW - Peptides

KW - Receptors, Chemokine

KW - T-Lymphocyte Subsets

KW - Th1 Cells

KW - Th2 Cells

KW - Transfection

KW - Up-Regulation

M3 - SCORING: Journal article

C2 - 12864987

VL - 140

SP - 177

EP - 187

JO - J NEUROIMMUNOL

JF - J NEUROIMMUNOL

SN - 0165-5728

IS - 1-2

ER -