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The cancer stem cell subtype determines immune infiltration of glioblastoma

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The cancer stem cell subtype determines immune infiltration of glioblastoma. / Beier, Christoph P; Kumar, Praveen; Meyer, Katharina; Leukel, Petra; Bruttel, Valentin; Aschenbrenner, Ines; Riemenschneider, Markus J; Fragoulis, Athanassios; Rümmele, Petra; Lamszus, Katrin; Schulz, Jörg B; Weis, Joachim; Bogdahn, Ulrich; Wischhusen, Jörg; Hau, Peter; Spang, Rainer; Beier, Dagmar.

In: STEM CELLS DEV, Vol. 21, No. 15, 10.10.2012, p. 2753-61.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Beier, CP, Kumar, P, Meyer, K, Leukel, P, Bruttel, V, Aschenbrenner, I, Riemenschneider, MJ, Fragoulis, A, Rümmele, P, Lamszus, K, Schulz, JB, Weis, J, Bogdahn, U, Wischhusen, J, Hau, P, Spang, R & Beier, D 2012, 'The cancer stem cell subtype determines immune infiltration of glioblastoma', STEM CELLS DEV, vol. 21, no. 15, pp. 2753-61. https://doi.org/10.1089/scd.2011.0660

APA

Beier, C. P., Kumar, P., Meyer, K., Leukel, P., Bruttel, V., Aschenbrenner, I., Riemenschneider, M. J., Fragoulis, A., Rümmele, P., Lamszus, K., Schulz, J. B., Weis, J., Bogdahn, U., Wischhusen, J., Hau, P., Spang, R., & Beier, D. (2012). The cancer stem cell subtype determines immune infiltration of glioblastoma. STEM CELLS DEV, 21(15), 2753-61. https://doi.org/10.1089/scd.2011.0660

Vancouver

Beier CP, Kumar P, Meyer K, Leukel P, Bruttel V, Aschenbrenner I et al. The cancer stem cell subtype determines immune infiltration of glioblastoma. STEM CELLS DEV. 2012 Oct 10;21(15):2753-61. https://doi.org/10.1089/scd.2011.0660

Bibtex

@article{f8f16b307e8741b4af6e5ccc9bff4494,
title = "The cancer stem cell subtype determines immune infiltration of glioblastoma",
abstract = "Immune cell infiltration varies widely between different glioblastomas (GBMs). The underlying mechanism, however, remains unknown. Here we show that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells (CSCs) in vivo and in vitro. In contrast, proneural GBM CSCs resisted TGF-beta due to TGFR2 deficiency. In vivo, a substantially increased infiltration of immune cells was observed in mesenchymal GBMs, while immune infiltrates were rare in proneural GBMs. On a functional level, proneural CSC lines caused a significantly stronger TGF-beta-dependent suppression of NKG2D expression on CD8(+) T and NK cells in vitro providing a mechanistic explanation for the reduced immune infiltration of proneural GBMs. Thus, the molecular subtype of CSCs TGF-beta-dependently contributes to the degree of immune infiltration.",
keywords = "Animals, Brain Neoplasms, Cell Line, Tumor, Cell Proliferation, Gene Expression Regulation, Neoplastic, Glioblastoma, Humans, Immunologic Factors, Mice, NK Cell Lectin-Like Receptor Subfamily K, Neoplasm Transplantation, Neoplastic Stem Cells, Oligonucleotide Array Sequence Analysis, Phosphorylation, Protein Processing, Post-Translational, Smad2 Protein, T-Lymphocytes, Cytotoxic, Transcriptional Activation, Transcriptome, Transforming Growth Factor beta, Tumor Burden",
author = "Beier, {Christoph P} and Praveen Kumar and Katharina Meyer and Petra Leukel and Valentin Bruttel and Ines Aschenbrenner and Riemenschneider, {Markus J} and Athanassios Fragoulis and Petra R{\"u}mmele and Katrin Lamszus and Schulz, {J{\"o}rg B} and Joachim Weis and Ulrich Bogdahn and J{\"o}rg Wischhusen and Peter Hau and Rainer Spang and Dagmar Beier",
year = "2012",
month = oct,
day = "10",
doi = "10.1089/scd.2011.0660",
language = "English",
volume = "21",
pages = "2753--61",
journal = "STEM CELLS DEV",
issn = "1547-3287",
publisher = "Mary Ann Liebert Inc.",
number = "15",

}

RIS

TY - JOUR

T1 - The cancer stem cell subtype determines immune infiltration of glioblastoma

AU - Beier, Christoph P

AU - Kumar, Praveen

AU - Meyer, Katharina

AU - Leukel, Petra

AU - Bruttel, Valentin

AU - Aschenbrenner, Ines

AU - Riemenschneider, Markus J

AU - Fragoulis, Athanassios

AU - Rümmele, Petra

AU - Lamszus, Katrin

AU - Schulz, Jörg B

AU - Weis, Joachim

AU - Bogdahn, Ulrich

AU - Wischhusen, Jörg

AU - Hau, Peter

AU - Spang, Rainer

AU - Beier, Dagmar

PY - 2012/10/10

Y1 - 2012/10/10

N2 - Immune cell infiltration varies widely between different glioblastomas (GBMs). The underlying mechanism, however, remains unknown. Here we show that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells (CSCs) in vivo and in vitro. In contrast, proneural GBM CSCs resisted TGF-beta due to TGFR2 deficiency. In vivo, a substantially increased infiltration of immune cells was observed in mesenchymal GBMs, while immune infiltrates were rare in proneural GBMs. On a functional level, proneural CSC lines caused a significantly stronger TGF-beta-dependent suppression of NKG2D expression on CD8(+) T and NK cells in vitro providing a mechanistic explanation for the reduced immune infiltration of proneural GBMs. Thus, the molecular subtype of CSCs TGF-beta-dependently contributes to the degree of immune infiltration.

AB - Immune cell infiltration varies widely between different glioblastomas (GBMs). The underlying mechanism, however, remains unknown. Here we show that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells (CSCs) in vivo and in vitro. In contrast, proneural GBM CSCs resisted TGF-beta due to TGFR2 deficiency. In vivo, a substantially increased infiltration of immune cells was observed in mesenchymal GBMs, while immune infiltrates were rare in proneural GBMs. On a functional level, proneural CSC lines caused a significantly stronger TGF-beta-dependent suppression of NKG2D expression on CD8(+) T and NK cells in vitro providing a mechanistic explanation for the reduced immune infiltration of proneural GBMs. Thus, the molecular subtype of CSCs TGF-beta-dependently contributes to the degree of immune infiltration.

KW - Animals

KW - Brain Neoplasms

KW - Cell Line, Tumor

KW - Cell Proliferation

KW - Gene Expression Regulation, Neoplastic

KW - Glioblastoma

KW - Humans

KW - Immunologic Factors

KW - Mice

KW - NK Cell Lectin-Like Receptor Subfamily K

KW - Neoplasm Transplantation

KW - Neoplastic Stem Cells

KW - Oligonucleotide Array Sequence Analysis

KW - Phosphorylation

KW - Protein Processing, Post-Translational

KW - Smad2 Protein

KW - T-Lymphocytes, Cytotoxic

KW - Transcriptional Activation

KW - Transcriptome

KW - Transforming Growth Factor beta

KW - Tumor Burden

U2 - 10.1089/scd.2011.0660

DO - 10.1089/scd.2011.0660

M3 - SCORING: Journal article

C2 - 22676416

VL - 21

SP - 2753

EP - 2761

JO - STEM CELLS DEV

JF - STEM CELLS DEV

SN - 1547-3287

IS - 15

ER -