The Callosal Relay Model of Interhemispheric Communication: New Evidence from Effective Connectivity Analysis
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The Callosal Relay Model of Interhemispheric Communication: New Evidence from Effective Connectivity Analysis. / Steinmann, Saskia; Meier, Jan; Nolte, Guido; Engel, Andreas K; Leicht, Gregor; Mulert, Christoph.
In: BRAIN TOPOGR, Vol. 31, No. 2, 03.2018, p. 218-226.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The Callosal Relay Model of Interhemispheric Communication: New Evidence from Effective Connectivity Analysis
AU - Steinmann, Saskia
AU - Meier, Jan
AU - Nolte, Guido
AU - Engel, Andreas K
AU - Leicht, Gregor
AU - Mulert, Christoph
PY - 2018/3
Y1 - 2018/3
N2 - Interhemispheric auditory connectivity via the corpus callosum has been demonstrated to be important for normal speech processing. According to the callosal relay model, directed information flow from the right to the left auditory cortex has been suggested, but this has not yet been proven. For this purpose, 33 healthy participants were investigated with 64-channel EEG while performing the dichotic listening task in which two different consonant-vowel syllables were presented simultaneously to the left (LE) and right ear (RE). eLORETA source estimation was used to investigate the functional (lagged phase synchronization/LPS) and effective (isolated effective coherence/ICoh) connectivity between right and left primary (PAC) and secondary auditory cortices (SAC) in the gamma-band (30-100 Hz) during right and left ear reports. The major finding was a significantly increased effective connectivity in the gamma-band from the right to the left SAC during conscious perception of LE stimuli. In addition, effective and functional connectivity was significantly enhanced during LE as compared to RE reports. These findings give novel insight into transcallosal information transfer during auditory perception by showing that LE performance requires causal interhemispheric inputs from the right to the left auditory cortices, and that this interaction is mediated by synchronized gamma-band oscillations.
AB - Interhemispheric auditory connectivity via the corpus callosum has been demonstrated to be important for normal speech processing. According to the callosal relay model, directed information flow from the right to the left auditory cortex has been suggested, but this has not yet been proven. For this purpose, 33 healthy participants were investigated with 64-channel EEG while performing the dichotic listening task in which two different consonant-vowel syllables were presented simultaneously to the left (LE) and right ear (RE). eLORETA source estimation was used to investigate the functional (lagged phase synchronization/LPS) and effective (isolated effective coherence/ICoh) connectivity between right and left primary (PAC) and secondary auditory cortices (SAC) in the gamma-band (30-100 Hz) during right and left ear reports. The major finding was a significantly increased effective connectivity in the gamma-band from the right to the left SAC during conscious perception of LE stimuli. In addition, effective and functional connectivity was significantly enhanced during LE as compared to RE reports. These findings give novel insight into transcallosal information transfer during auditory perception by showing that LE performance requires causal interhemispheric inputs from the right to the left auditory cortices, and that this interaction is mediated by synchronized gamma-band oscillations.
KW - Adult
KW - Auditory Cortex/physiology
KW - Auditory Pathways/physiology
KW - Auditory Perception/physiology
KW - Corpus Callosum/physiology
KW - Dichotic Listening Tests
KW - Electroencephalography
KW - Female
KW - Functional Laterality/physiology
KW - Humans
KW - Male
KW - Middle Aged
KW - Young Adult
U2 - 10.1007/s10548-017-0583-x
DO - 10.1007/s10548-017-0583-x
M3 - SCORING: Journal article
C2 - 28803269
VL - 31
SP - 218
EP - 226
JO - BRAIN TOPOGR
JF - BRAIN TOPOGR
SN - 0896-0267
IS - 2
ER -
